The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Genomic 5-methyldeoxycytidine decreases with age.
Open accessAbstract
Significant losses of DNA 5-methyldeoxycytidine residues in old age could disrupt cellular gene expression and contribute to the physiological decline of the animal. Thus, the 5-methyldeoxycytidine content of DNAs, isolated from the tissues of two rodent species of various ages, were determined. Mus musculus lost DNA methylation sites at a rate of about 4.7 X 10(4) (approximately 0.012% of the newborn level)/month. Peromyscus leucopus lost DNA 5-methyldeoxycytidine residues at a rate of only 2.3 X 10(4) (approximately 0.006% of the newborn level)/month. Since P. leucopus generally live twice as long as M. musculus, the rate of loss of DNA 5-methyldeoxycytidine residues appears to be inversely related to life span. Similar losses in genomic 5-methyldeoxycytidine content were also observed to correlate with donor age in cultured normal human bronchial epithelial cells.
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Cites
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DNA Methylation Decreases in Aging But Not in Immortal Cells
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Cited by
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
DNA methylation and healthy human aging
Jones, M. J., Goodman, S. J., & Kobor, M. S. (2015) · Aging Cell · doi:10.1111/acel.12349 · Cited by 928
Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring
Cooney, C. A., Dave, A. A., & Wolff, G. L. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.8.2393s · Cited by 784
Endogenous Oxidative DNA Damage, Aging, and Cancer
Ames, B. N. (1989) · Free Radical Research Communications · doi:10.3109/10715768909087933 · Cited by 699
Metadata
- Authors
- Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 262
- Issue
- 21
- Pages
- 9948-9951
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1597628009
- Cited by
- 521
- References
- 27
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
