The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Endogenous Oxidative DNA Damage, Aging, and Cancer
Abstract
Progress in identifying the important endogenous processes damaging DNA and developing methods to assay this damage in individuals is presented. This approach may aid studies on modulation of cancer and aging. The endogenous background level of oxidant-induced DNA damage in vivo has been assayed by measuring 8-hydroxydeoxyguanosine (oh8dG), thymine glycol and thymidine glycol in urine and oh8dG in DNA. oh8dG is one of about 20 adducts found on oxidizing DNA, e.g., by radiation. The level of oxidative DNA damage as measured by oh8dG in normal rat liver is shown to be extensive, especially in mtDNA (1/130,000 bases in nuclear DNA and 1/8,000 bases in mitochondrial DNA). We also discuss three hitherto unrecognized antioxidants in man.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Dietary Carcinogens and Anticarcinogens: Oxygen radicals and degenerative diseases
Ames, B. N. (1983) · Science · doi:10.1126/science.6351251 · Cited by 2,969
Self-citationBilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 2,948
Self-citationAmes, B. N., Cathcart, R., Schwiers, E., & Hochstein, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6858 · Cited by 2,909
Self-citationThe Chemical Basis of Radiation Biology
O'Neill, P. (1987) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553008714552571 · Cited by 1,835
The chemical basis of radiation biology
von Sonntag, C. (1987) · Medical Entomology and Zoology · Cited by 1,760
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,725
Self-citationThe Inheritance of Epigenetic Defects
Holliday, R. (1987) · Science · doi:10.1126/science.3310230 · Cited by 1,082
Kasai, H., Crain, P. F., Kuchino, Y., Nishimura, S., Ootsuyama, A., & Tanooka, H. (1986) · Carcinogenesis · doi:10.1093/carcin/7.11.1849 · Cited by 924
Lindahl, T. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.000425 · Cited by 895
Cited by
Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106
Self-citationCuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087
Metadata
- Authors
- Ames, B. N.
- Venue
- Free Radical Research Communications
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 7
- Issue
- 3-6
- Pages
- 121-128
- ISSN
- 8755-0199 (ISSN-L)
- OpenAlex
- W2099530293
- Cited by
- 699
- References
- 34
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endogenous Oxidative DNA Damage, Aging, and Cancer. https://app.cochat.ai/papers/10.3109/10715768909087933
- The paper
- Ames, B. N. (1989). Endogenous Oxidative DNA Damage, Aging, and Cancer. Free Radical Research Communications. https://doi.org/10.3109/10715768909087933
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
