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Cited by 238

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

Davis, C.G., van Driel, I.R., Russell, D.W., Brown, M.S., Goldstein, J.L.·1987·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)61313-4
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Abstract

The 50-residue cytoplasmic domain of the low density lipoprotein receptor (amino acids 790-839) directs the receptor to coated pits, thereby facilitating rapid endocytosis of bound low density lipoprotein. To determine the structural features required for this targeting, we produced 24 mutations in the cytoplasmic domain through use of oligonucleotide-directed mutagenesis. The first 22 amino acids of the cytoplasmic domain (residues 790-811) are sufficient for rapid internalization. The amino acid at position 807 is especially critical. Aromatic residues (tyrosine, phenylalanine, or tryptophan) at this position allow rapid internalization. Charged or uncharged aliphatic residues do not substitute. Although the requirements at the neighboring positions (806 and 808) are less stringent, the insertion of proline at position 806 is detrimental. These specificities suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits.

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Crossref · 10.1016/s0021-9258(18)61313-4

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Citations

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Research works printed but not linked: 37

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Metadata

Authors
Davis, C. G., van Driel, I. R., Russell, D. W., Brown, M. S., & Goldstein, J. L.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1987-03
Volume
262
Issue
9
Pages
4075-4082
ISSN
0021-9258
DOI
10.1016/s0021-9258(18)61313-4
Cited by
238
References
1
Language
en
Licence

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