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Cited by 369

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Control of Ribonucleic Acid Synthesis in Escherichia coli

Open access
Cashel, Michael, Kalbacher, Barbara·1970·Journal of Biological Chemistry

Abstract

Abstract The preceding paper in this series presented evidence implicating an unusual phosphorylated compound (MS I) as a possible inhibitor of RNA accumulation during amino acid starvation of stringent strains of Escherichia coli. Here a method is described for isolating MS I from batch cultures of a stringent valyl transfer RNA synthetase mutant. Chemical analyses indicate that MS I is a tetraphosphate of guanosine. However, in contrast to previously described isomers of guanosine tetraphosphate (ppppG and pppGp), MS I is labile in alkali. Charge considerations, enzyme degradation studies, and labilities in acid and alkali lead to a structural assignment for MS I of guanosine 5'-diphosphate or 3'- or 2'-diphosphate (ppGpp).

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Metadata

Authors
Cashel, M., & Kalbacher, B.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1970-05
Volume
245
Issue
9
Pages
2309-2318
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1597428765
Cited by
369
References
1
FWCI
37.20
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The Control of Ribonucleic Acid Synthesis in Escherichia coli. https://app.cochat.ai/papers/10.1016/s0021-9258(18)63153-9
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Cashel, M., & Kalbacher, B. (1970). The Control of Ribonucleic Acid Synthesis in Escherichia coli. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)63153-9

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.