Cited by 1,283Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation MechanismsMicrobial metabolism and enzyme function

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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Axelrod, Julius, Tomchick, Robert·1958·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)64731-3

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ON TYROSINE AND TRYPTOPHANE DETERMINATIONS IN PROTEINS
Folin, O., & Ciocalteu, V. (1927) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84277-6 · Cited by 2,990
The chemical estimation of adrenaline-like substances in blood
Weil‐Malherbe, H., & Bone, A. D. (1952) · Biochemical Journal · doi:10.1042/bj0510311 · Cited by 481
O-Methylation of Epinephrine and Other Catechols in vitro and in vivo
Axelrod, J. (1957) · Science · doi:10.1126/science.126.3270.400 · Cited by 362
3-Methoxy-4-hydroxy-D-mandelic acid, a urinary metabolite of norepinephrine
Armstrong, M. D., McMillan, A., & Shaw, K. N. F. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90491-2 · Cited by 353
O-Methylation of Catechol Amines in Vivo
Axelrod, J., Senoh, S., & Witkop, B. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64730-1 · Cited by 207
METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER
Cantoni, G. L. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56110-x · Cited by 197
URINARY METABOLITES OF CAFFEIC AND CHLOROGENIC ACIDS
Booth, A. N., Emerson, O. H., Jones, F. T., & DeEds, F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70592-9 · Cited by 181
THE METABOLISM OF 3,4-DIHYDROXYPHENYLALANINE
Shaw, K. N. F., McMillan, A., & Armstrong, M. D. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64827-6 · Cited by 138
O-methylation, the principal pathway for the metabolism of epinephrine and norepinephrine in the rat
Axelrod, J., Inscoe, J. K., Senoh, S., & Witkop, B. (1958) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(58)90316-0 · Cited by 121
ENZYMATIC MECHANISM OF CREATINE SYNTHESIS
Cantoni, G. L., & Vignos, P. J. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65492-4 · Cited by 117

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von Etiler, 1955, Acta Physiol-Scand., 33, 118
Cantoni, 1957, 3, 600
von Euler, 1955, Acta Physiol. Scand., 33, 118, 45
Warburg, 1941, Biochem. Z., 310, 384
LaBrosse, 1958, Federation Proc., 17, 386

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(1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb08074.x · Cited by 6
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Adrenal enzymes of catecholamine biosynthesis and metabolism in spontaneously hypertensive rats
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ADRENERGIC MECHANISM OF THE DRUGS. SYSTEMIC ARTERIAL PRESSURE CHANGES CAUSED BY INTRAVENOUS INJECTION OF RESERPINE FOLLOWING THE ADMINISTRATION OF PHENIPRAZINE AND PYROGALLOL IN ANESTHETIZED DOGS
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Haefely, W. E., Bartholini, G., & Pletscher, A. (1976) · Pharmacology & Therapeutics Part B General and Systematic Pharmacology · doi:10.1016/0306-039x(76)90030-1 · Cited by 6
Purification de la catéchol-O-méthyltransférase (EC. 2.1.1.6) du placenta humain et étude de quelques propriétés
Darmenton, P., Cronenberger, L. A., & Pachéco, H. (1977) · Biochimie · doi:10.1016/s0300-9084(77)80024-2 · Cited by 6
Erythrocyte catechol-O-methyltransferase activity in pregnant women with pregnancy-induced hypertension
Bates, G. W., Whitworth, N. S., & Jackson, E. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32332-8 · Cited by 6
Hypertonie und erhöhte Katecholaminausscheidung
Sturm, A. (1966) · Basic Research in Cardiology · doi:10.1007/bf02119842 · Cited by 6
Splanchnic and renal contribution to disposal of infused epinephrine in humans
Saccà, L., Hendler, R., Picardi, A., & Sherwin, R. S. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.3.e285 · Cited by 6
Neurochemistry and Psychiatry
Waelsch, H., & Weil‐Malherbe, H. (1964) · Springer eBooks · doi:10.1007/978-3-642-94902-9_1 · Cited by 6
Demethylation of 3-O-methyldopa.
Chalmers, J. P., Davies, D. S., Draffan, G. H., Reid, J. L., & Thorgeirsson, S. S. (1971) · PubMed Central · Cited by 6
Monoaminoxydase-Hemmer
Pletscher, A., GEY, K. F., & Zeller, P. (1960) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7038-2_8 · Cited by 6
Electrophysiological Deficits in Schizophrenia: Models and Mechanisms
von Reyn, C. R., Michael, E., Freedman, R., Valerie, M., Michael, J., Chinn, G. A., & Steven, J. (2011) · InTech eBooks · doi:10.5772/27511 · Cited by 5
MAOA Influences the Trajectory of Attentional Development
Lundwall, R. A., & Rasmussen, C. G. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00424 · Cited by 5
“Associated to with ADHD in children (Faraone and Mick, 2010) COMT G at rs4680 produces valine which is more active in catabolizing dopamine making dopamine less available (Axelrod and Tomchick, 1958).”
Background
Interspecies comparison in the COMT-mediated methylation of 3-BTD
Xia, Y., Pang, H.-L., Dou, T., Wang, P., & Ge, G. (2018) · RSC Advances · doi:10.1039/c8ra01938j · Cited by 5
Influence of Metabolic, Transporter, and Pathogenic Genes on Pharmacogenetics and DNA Methylation in Neurological Disorders
Martínez-Iglesias, O. A., Naidoo, V., Carrera, I., Carril, J. C., Cacabelos, N., & Cacabelos, R. (2023) · Biology · doi:10.3390/biology12091156 · Cited by 4
“Endogenous substrates of COMT include dopamine, norepinephrine, and epinephrine [67] and there is a significant association between the COMT rs4680 SNP and the response to antidepressant treatment [69].”
Background
HYPOTHERMIA ENHANCES THE EFFECTS OF MORPHINE ON HORMONAL AND HISTAMINE RELEASE
Alcaraz, C., Bansinath, M., Turndorf, H., & Puig, M. (1989) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1989.tb01573.x · Cited by 5
Push–Pull Superfusion: A Technique for Investigating Involvement of Neurotransmitters in Brain Function
Philippu, A., & Kraus, M. M. (2016) · Neuromethods · doi:10.1007/978-1-4939-6490-1_10 · Cited by 5
Effects of Aromatic Aldehydes on O-Methylation of Dopamine and Norepinephrine in in Vitro
Ho, B. T., Gardner, P. M., Englert, L. F., & Walker, K. E. (1974) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600630820 · Cited by 5
Detecting metabolites of different transition metallithospermate B complexes after intravenous injection in rats
Chen, Y., Chung, T., Chen, W., Chen, C., Lee, M.-R., Jinn, T., & Tzen, J. T. C. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.37 · Cited by 5
The activity of Catechol-O-Methyltransferase in parkinsonian patients with "on-off fluctuations"
Woitalla, D., Karwasz, R., Müller, T., Przuntek, H., & Kuhn, W. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050009 · Cited by 5
Lack of Associations of the COMT Val158Met Polymorphism with Risk of Endometrial and Ovarian Cancer: a Pooled Analysis of Case-control Studies
Liu, J., Luo, R., Li, R., Li, X., Yu-wu, G., Ding, D., & Chen, Y.-Z. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.15.6181 · Cited by 5
The relationship of early studies of monoamine oxidase to present concepts
Kopin, I. J. (2006) · Springer eBooks · doi:10.1007/978-3-211-33328-0_9 · Cited by 5
Rat Liver Catechol-O-Methyltransferase Kinetics and Assay Methodology
Borges, N., Vieira‐Coelho, M. A., Parada, A., & Soares-da-Silva, P. (1998) · Journal of enzyme inhibition · doi:10.3109/14756369809020551 · Cited by 5
THE BIOSYNTHESIS OF AMINO ACIDS
Mattoon, J. R. (1963) · Elsevier eBooks · doi:10.1016/b978-0-08-002925-2.50007-3 · Cited by 5

Authors: Axelrod, J., & Tomchick, R.
Affiliations: United States Public Health Service (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1958-09
Volume: 233
Issue: 3
Pages: 702-705
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)64731-3
OpenAlex: W1543624067
Cited by: 1,283
References: 16
Citations by year: 2026: 6 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 28 · 2015: 12 · 2014: 14 · 2013: 19 · 2012: 21
FWCI: 55.85
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 22705 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords: epinephrine, catechol, O-methylation, enzymatic methylation, catecholamine metabolism
MeSH terms: Catechols, Epinephrine, Methylation, Norepinephrine, Transferases

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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