Cited by 1,283Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation MechanismsMicrobial metabolism and enzyme function

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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Axelrod, Julius, Tomchick, Robert·1958·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)64731-3

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ON TYROSINE AND TRYPTOPHANE DETERMINATIONS IN PROTEINS
Folin, O., & Ciocalteu, V. (1927) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84277-6 · Cited by 2,990
The chemical estimation of adrenaline-like substances in blood
Weil‐Malherbe, H., & Bone, A. D. (1952) · Biochemical Journal · doi:10.1042/bj0510311 · Cited by 481
O-Methylation of Epinephrine and Other Catechols in vitro and in vivo
Axelrod, J. (1957) · Science · doi:10.1126/science.126.3270.400 · Cited by 362
3-Methoxy-4-hydroxy-D-mandelic acid, a urinary metabolite of norepinephrine
Armstrong, M. D., McMillan, A., & Shaw, K. N. F. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90491-2 · Cited by 353
O-Methylation of Catechol Amines in Vivo
Axelrod, J., Senoh, S., & Witkop, B. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64730-1 · Cited by 207
METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER
Cantoni, G. L. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56110-x · Cited by 197
URINARY METABOLITES OF CAFFEIC AND CHLOROGENIC ACIDS
Booth, A. N., Emerson, O. H., Jones, F. T., & DeEds, F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70592-9 · Cited by 181
THE METABOLISM OF 3,4-DIHYDROXYPHENYLALANINE
Shaw, K. N. F., McMillan, A., & Armstrong, M. D. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64827-6 · Cited by 138
O-methylation, the principal pathway for the metabolism of epinephrine and norepinephrine in the rat
Axelrod, J., Inscoe, J. K., Senoh, S., & Witkop, B. (1958) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(58)90316-0 · Cited by 121
ENZYMATIC MECHANISM OF CREATINE SYNTHESIS
Cantoni, G. L., & Vignos, P. J. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65492-4 · Cited by 117

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Background
Determination of phenylethanolamine N-methyltransferase by high-performance liquid chromtography with fluorescence detection
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“Catechol-O-methyltransferase (COMT; E.C. 2.1.1.6) catalyses the transfer of a methyl group from S-adenosyl-l-methionine (SAM) to a hydroxyl group on a catechol substrate in the presence of magnesium (Axelrod & Tomchick, 1958).”
BackgroundInfluential
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I. Catecholamines in developing rat lung
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Catechol-O-Methyl Transferase (Comt) in Skin of Patients with Psoriasis**From the Department of Medicine, Division of Dermatology, University of Missouri Medical School, Columbia, Missouri 65201.
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Role of Dopamine in Generalized Photosensitive Epilepsy: Electroencephalographic and Biochemical Aspects
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Authors: Axelrod, J., & Tomchick, R.
Affiliations: United States Public Health Service (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1958-09
Volume: 233
Issue: 3
Pages: 702-705
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)64731-3
OpenAlex: W1543624067
Cited by: 1,283
References: 16
Citations by year: 2026: 6 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 28 · 2015: 12 · 2014: 14 · 2013: 19 · 2012: 21
FWCI: 55.85
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 22705 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords: epinephrine, catechol, O-methylation, enzymatic methylation, catecholamine metabolism
MeSH terms: Catechols, Epinephrine, Methylation, Norepinephrine, Transferases

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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