LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE

The Determination of Enzyme Dissociation Constants

Lineweaver, H., & Burk, D. (1934) · Journal of the American Chemical Society · doi:10.1021/ja01318a036 · Cited by 12,031

A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETECTION AND DETERMINATION OF KETO SUGARS AND TRIOSES

Dische, Z., & Borenfreund, E. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77782-5 · Cited by 1,108

SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE

Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 599

The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues.

Woodward, G. E., & Hudson, M. T. (1954) · PubMed · Cited by 158

2-Desoxy-D-glucose as an antagonist of glucose in yeast fermentation

Cramer, F. B., & Woodward, G. E. (1952) · Journal of the Franklin Institute · doi:10.1016/0016-0032(52)90852-1 · Cited by 123

SUGAR UTILIZATION IN EVISCERATED RABBITS

Drury, D. R. (1935) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1935.111.2.289 · Cited by 107

The Action of Ammonia on Allophanic Azide

LIPSCHITZ, W. L. (1944) · Journal of the American Chemical Society · doi:10.1021/ja01232a510 · Cited by 54

2-Deoxyglucose--A Metabolic Block for Glucose.

Wick, A. N., Drury, D. R., & Morita, T. N. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-89-21881 · Cited by 41

Über die ungesättigten Reduktionsprodukte der Zuckerarten und ihre Umwandlungen, III.: Über 2‐Desoxyglucose (Gluco‐desose)

Bergmann, M. F., Schotte, H., & Lechinsky, W. (1922) · Berichte der deutschen chemischen Gesellschaft (A and B Series) · doi:10.1002/cber.19220550122 · Cited by 41

The effect of 6-deoxy-6-fluoro-d-glucose on yeast fermentation and on hexokinase

Blakley, E. R., & Boyer, P. D. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90281-x · Cited by 32

2-deoxyglucose-stimulated fermentation in yeast cells; possible relationship to cyclic fermentation in extracts

Scharff, T. G., & Montgomery, O. L. (1965) · Life Sciences · doi:10.1016/0024-3205(65)90224-9 · Cited by 2

Relationship between Heart Function and Energy Production. A Study on Isolated Rat Heart

Poizat, C. I., Grably, S., Cuchet, P., & Kériel, C. (1996) · Archives of Physiology and Biochemistry · doi:10.1076/apab.104.1.71.12874 · Cited by 2

EFFECTS OF 2‐DEOXY‐ d ‐GLUCOSE ON THE GROWTH AND METABOLISM OF PROTOTHECA ZOPFII KRÜGER

RANA, M. S., & Casselton, P. J. (1974) · New Phytologist · doi:10.1111/j.1469-8137.1974.tb01293.x · Cited by 2

Central carbon metabolism is an intrinsic factor for optimal replication of a norovirusPreprint

Passalacqua, K. D., Lu, J. Q., Goodfellow, I., Kolawole, A. O., Arche, J. R., Maddox, R. J., O’Riordan, M. X., & Wobus, C. E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/434019 · Cited by 2

Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypesPreprint

Ghiaci, P., Jouhten, P., Martyushenko, N., Roca-Mesa, H., Vázquez, J., Konstantinidis, D., Stenberg, S., Andrejev, S., Grkovska, K., Mas, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.18.488345 · Cited by 2

Glucose protects cultured retinal cells from oxidative injury via the pentose phosphate pathway

Wood, J. P. M., Chidlow, G., & Casson, R. J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.006 · Cited by 1

Synergistic Effects of 2-Deoxyglucose and Diclofenac Sodium on Breast Cancer Cells: A Comparative Evaluation of MDA-231 and MCF7 Cells

Maloba, G. O., Were, T., Barasa, E., Mohamed, N., Arshi, A., & Gallyas, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104894 · Cited by 1

PDC1 deficiency results in 2‐deoxyglucose sensitivity through inhibition of Pdc2 activity in yeast

Kubota, M., Seki, D., Nakamura, H., Hosomi, A., Inoue, Y., & Nomura, W. (2026) · FEBS Journal · doi:10.1111/febs.70640 · Cited by 1

Effect of glucose analogues on synthesis of sugar nucleotides and oligosaccharides inSaccharomyces cerevisiae

Herr, D., & Dellweg, H. (1975) · Applied Microbiology and Biotechnology · doi:10.1007/bf01880619 · Cited by 1

In Saccharomyces cerevisiae the attenuation of the 2- deoxy-D-glucose toxicity is alleviated by inositol

Chidambaram, R., & Nachiappan, V. (2019) · International Journal of Scientific Research in Biological Sciences · doi:10.26438/ijsrbs/v5i6.5660 · Cited by 1

The Influence of Metabolic Inhibitors, Antibiotics, and Microgravity on Intact Cell MALDI-TOF Mass Spectra of the Cyanobacterium Synechococcus Sp. UPOC S4

Šebela, M., Raus, M., Ondřej, V., & Hašler, P. (2021) · Molecules · doi:10.3390/molecules26061683 · Cited by 1

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks

Laurent, F., Gross, R., Lakili, M., & Mialhe, P. (1981) · Diabetologia · doi:10.1007/bf01789118 · Cited by 1

From the Thyroid to the Heart

Moncayo, R., & Moncayo, H. (2023) · Global Journal of Medical Research · doi:10.34257/gjmrkvol23is1pg1 · Cited by 1

Effect of 2-Deoxyglucose on Bovine Spermatozoan Metabolism and Preservation

Lodge, J. R., Harms, P. G., & Graves, C. N. (1968) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(68)87129-2 · Cited by 1

Pharmacological interventions part IV: Metabolic modifiers

Koltai, T., Reshkin, S. J., & Harguindey, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819059-3.00016-2 · Cited by 1

Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism

Jha, S. K., Yadav, R., Swati, K., Jha, N. K., Sharma, A., Khan, F., Kumar, N., Nand, P., Kaur, P., Gover, T., et al. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_10 · Cited by 1

Relation between 2-deoxyglucose phosphorylation and adenine nucleotide content in Lettré ascites cells.

Meisner, H. M. (1967) · PubMed · Cited by 1

�ber die Hemmung der Pyruvatverwertung und den Anstau von Citrat in Tumor-Asciteszellen bei Gegenwart von 2-Desoxy-D-Glukos

Seelich, F., & Letnansky, K. (1961) · Die Naturwissenschaften · doi:10.1007/bf00609109 · Cited by 1

Effect of glucose on potassium contracture tension in rat heart

Berman, D. A. (1973) · Life Sciences · doi:10.1016/0024-3205(73)90035-0 · Cited by 1

Reduction of neointimal hyperplasia in porcine coronary arteries by 2-deoxy-d-glucose

NEF, H. M., Möllmann, H., Joseph, A., Troidl, C., Voss, S., Rauch, M., Kinscherf, R., Vogt, A. M., Weber, M. W., Hamm, C. W., et al. (2009) · Clinical Research in Cardiology · doi:10.1007/s00392-009-0020-6 · Cited by 1

Der Einflu� der durch 2-Desoxy-D-Glucose verursachten Atmungshemmung auf Synthesevorg�nge in Ascites-Tumor-Zellen

Sauermann, G., & Seelich, F. (1963) · Die Naturwissenschaften · doi:10.1007/bf00597456 · Cited by 1

Effect of sugars and metabolic intermediates on the attachment of Treponema pallidum to rabbit cells

Wong, G. H., & Steiner, B. M. (1984) · Journal of Medical Microbiology · doi:10.1099/00222615-17-2-121 · Cited by 1

Elucidation of Feeding-Related Neuronal Networks Involved in the Regulation of the Hypophysiotropic Thyrotropin-Releasing Hormone- and Corticotropin-Releasing Hormone-Synthesizing Neurons in the Rat

Wittmann, G. (2008) · Hungarian Medical Journal · doi:10.1556/hmj.2.2008.28343 · Cited by 1

REVIEWING ARTICLE: ISCHAEMIC AND METABOLIC TREATMENT OF HEPATIC TUMOURS

AHRtN, B. (1988) · Cited by 1

The purification and properties of a hexokinase from the corn scutellum / by Herbert Charles Jones.

Jones, H. C. (1965) · doi:10.5962/bhl.title.35150 · Cited by 1

Inhibition of peroxide removal systems and ascorbate-induced cytotoxicity in pancreatic cancer

Beek, H. V., Cullen, J. J., Quelle, D. E., & Koland, J. G. (2016) · doi:10.17077/etd.64g3ppkx · Cited by 1

Forkhead genes in adipocytes and podocytes

Nilsson, D. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1

The regulation of HAD-like phosphatases by signaling pathways modulates cellular resistance to the metabolic inhibitor, 2-deoxyglucosePreprint

Defenouillère, Q., Verraes, A., Laussel, C., Friedrich, A., Schacherer, J., & Sébastien Léon, A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/504134 · Cited by 1

INSULIN AND THE RESPONSE OF THE PANCREATIC A CELL TO GLUCOSE IN THE DUCK

Laurent, F., & Mialhe, P. (1981) · Elsevier eBooks · doi:10.1016/b978-0-08-027355-6.50056-x · Cited by 1

Oxidative stress potentiates the therapeutic action of a mitochondrial complex I inhibitor in MYC-driven B-cell lymphomaPreprint

Donati, G., Nicoli, P., Verrecchia, A., Vallelonga, V., Croci, O., Rodighiero, S., Audano, M., Cassina, L., Ghsein, A., Binelli, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.21.497021 · Cited by 1

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathwayPreprint

Zhang, J., Chang, J., Chen, W., Beg, M. A., Huang, W., Vick, L., Wang, Y., Zhang, H., yttre, E., Gupta, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.07.556574 · Cited by 1

An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells

Eng, G. T. A. (2015) · QUT ePrints (Queensland University of Technology) · Cited by 1

Energy Compartmentation and Active Transport in Proximal Kidney Tubules

Mandel, L. J., Soltoff, S. P., & Brazy, P. C. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5107-8_16

A combinatorial preclinical in vitro strategy against human glioblastoma cells. specific targeting of protein kinases, histone deacetylases and glycolysis

Egler, V. (2009) · edoc (University of Basel) · doi:10.5451/unibas-005031509

インスリン分泌機序に関する研究--インスリン分泌と膵ラ氏島B細胞の糖代謝,とくにATPの関与について

川口, 侃. (1976) · Kobe University Repository Kernel (Kobe University) · doi:10.11213/tonyobyo1958.19.30

The effect of digitoxose on feeding behavior

Brown, D., & Viles, J. (1983) · Experientia · doi:10.1007/bf01989763

Rot diaphragm studies with 3-deoxyglucose (3-deoxy- d-ribohexose)

Segal, S., & Conrad, J. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90279-x

Effect of cold and glucoprivation on TSH and T4 release in normothermic and hyperthermic rats

Udeschini, G. (1982) · Pharmacological Research Communications · doi:10.1016/s0031-6989(82)80076-3

Esquema de restrição alimentar altera a resposta celular à insulina em ratos diabéticos

Sumida, D. H., Okamoto, M. M., Lima, F. B., Machado, U. F., & Hell, N. S. (2000) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302000000400010

Bases moleculares das ações rápidas do T3 na captação de glicose em célula adiposa 3T3-L1.

Croffi, R. V. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2015.tde-02062015-131022

Über den Effekt von 2-Deoxy-D-Glucose und Mannoheptulose auf die durch gastrointestinale Hormone induzierte Insulinsekretion

Lucke, C., Höffken, B., Mitzkat, H. J., & TRAUTSCHOLD, I. (1973) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-47087-5_366

Enhanced insulin sensitivity mediated by adipose tissue browning perturbs islet morphology and hormone secretion in response to autonomic nervous activation in female mice

Omar, B. A., Reimer, M. K., Enerbäck, S., & Åhrén, B. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2015

EFFECT OF 2-DEOXY-D-GLUCOS E ON MAINTENANCE IN

Yoshida, K., Kagawa, S., Murakoso, K., & Matsuoka, A. (1984)

Isotopes in studies with antimetabolites

Binkley, S. B. (1961) · Springer eBooks · doi:10.1007/978-3-642-49762-9_32

A Possible Role for the Adenylcyclase System in

Malaisse, W. J., MALAISSE-LAGAE, F., & Mayhew, D. A. (1967)

Einfluß von Guanidinoverbindungen auf die Glucoseaufnahme in isolierten Fettzellen

Weitzel, G., & Hadjianghelu, A. (1982) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1982.363.1.45

IN VIVO 31P NMR STUDIES OF BACTERIAL AND MAMMALIAN CELLS

Shulman, R. G., Nauon, G., Ogawa, S., Yamane, T., Glynn, P., Brown, T. R., Uǧurbil, K., & Rottenberg, H. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-043950-8.50026-7

Der Einfluß von 2-Deoxy-D-Glucose auf Säuresekretion, Serumgastrin und Insulin beim Hund

Feurle, G. E., Klempa, I., Becker, R., & Helmstädter, V. (1975) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85450-7_333

Metabolic Responsiveness of a Novel GnRH-GFP Neuronal Cell Model

McFadden, S. A. (2010) · TSpace (University of Toronto)

Synthesis of Halogenated-4-Nitrophenyl 2-deoxy-2-halogeno-pyranosides via N -Halogenosuccinimide Activated Glucal

Inoue, C., OKAMOTO, Y., Vavricka, C. J., Kiyota, H., & Izumi, M. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300125

The Contribution Of Metabolism To The Regulation Of Caspase Activity And Cell Death In T Lymphocytes

Secinaro, M. A. (2019) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)

Regulation of B cell metabolic activation, germinal center responses and autoimmunity by Tandem PH domain-containing proteins

Jayachandran, N. (2016) · Mspace (University of Manitoba)

Positron-Emitting Radiopharmaceuticals

Salvadori, P. A., Filidei, E., & Giorgetti, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-95564-3_3

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Scapin, G., Goulard, M. C., Dharampuriya, P. R., Cillis, J. L., & Shah, D. I. (2019) · Journal of Visualized Experiments · doi:10.3791/60234

The lack of UME6 sustain 2- deoxy-D-glucose toxicity under inositol limitation condition in Saccharomyces cerevisiae

Chidambaram, R., & Nachiappan, V. (2019) · International Journal of Scientific Research in Biological Sciences · doi:10.26438/ijsrbs/v6i1.2933

Selective manipulation of tumour cell energy metabolism

Sri-Pathmanathan, R. M. (1988) · Enlighten: Theses (The University of Glasgow)

Cystathionine gamma-lyase/hydrogen sulfide system and glucose homeostasis

Zhang, L. (2013) · Knowledge Commons (Lakehead University)

Novel Pharmacological Inhibitors for Bacterial Protein Toxins

Barth, H. (2017) · MDPI eBooks · doi:10.3390/books978-3-03842-431-4

Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets

Villarreal, B., & Nadilly, Y. (2021) · Figshare

Properties of glutamate uptake in salamander Müller cells

Barbour, B. (1991) · UCL Discovery (University College London)

2-Deoxy Glucose: A Ray of Hope for Treatment of Covid-19

Sharma, A., Gull, A., Jain, N., & Meena, V. (2021) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2021.v70i01.014

ERRATUM

(1984) · Pediatric Research · doi:10.1203/00006450-198405000-00021

Dependence of Cholecystokinin-8-Stimulated Insulin Release on High Glucose Levels Is Evidenced by Pseudo-α-D-Glucose in Rat Pancreas and Islets

Kimura, I., Nakashima, N., Komori, T., Kameda, Y., & Kimura, M. (1994) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)35872-x

Estudos genômicos da expressão gênica global do fungo filamentoso Trichoderma reesei crescido em bagaço e colmo de cana-de-açúcar

Borin, G. (2015) · doi:10.47749/t/unicamp.2015.947980

Elevated Pentose Phosphate Pathway Flux Drives Appendage RegenerationPreprint

Patel, J. H., Ong, D. J., Williams, C., Callies, K., & Wills, A. E. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4138706

Characterizing Metabolic Changes in Cancer Cells After Treatment with an Extract Created from Walnuts

Huang, C. Y. (2022) · doi:10.31979/etd.5yvb-sh7e

Sugar co-ordinates plant defence signallingPreprint

Yamada, K., & Mine, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549975

Anticancer effect of metformin alone and in combination with 2-deoxy-D-glucose on mouse T cell lymphoma EL4 cells

Kim, S. H., & Joo, H. (2023) · Korean Journal of Veterinary Research · doi:10.14405/kjvr.20230026

Interplay of methylglyoxal and immune cells

Zhang, X. (2023) · doi:10.26481/dis.20231213xz

GEQO biosensors for absolute analyte quantification in single cellsPreprint

Kuhn, S. M., Nerli, E., Liu, J., Kaufmann, S., Barahtjan, P., Buitrago-Arango, M., Geertsma, E. R., Mateus, R., Grapin‐Botton, A., & Nadler, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.652245

Protocol for measuring in vivo, ex vivo, and in vitro glucose uptake in brown adipocytes

Park, C., & Chang, J. S. (2025) · STAR Protocols · doi:10.1016/j.xpro.2025.104244

Differential regulation of autophagy by therapeutic and physiologic glucose restriction under normoxia and hypoxia

Xi, H. (2012)

Nutritional improvement for children in urban Chile and Kenya

Pridmore, P., Carr‐Hill, R., McCowan, T., Amuyunzu-Nyamongo, M., Lang'o, D., & Charnes, G. (2016) · UK Data Archive · doi:10.5255/ukda-sn-851438

Metabolic fueling of hematopoietic stem cell differentiation to the erythroid lineage

Oburoglu, L. (2014) · theses.fr (ABES) · doi:10.70675/2a8ca582z1bd3z4b90z96c1z5964d1e426b9

Métabolisme énergétique et thérapie anticancéreuse : caractérisation des effets de dérivés désoufrés de la troglitazone sur les cellules d’adénocarcinomes mammaires

Muller, C. (2019) · theses.fr (ABES) · doi:10.70675/bb626f86za38az4d58za5e5z00f045dc0476

Mapping Slow Speckle Dynamics to Probe Cellular Metabolic Activity In Vivo using Laser Speckle Contrast ImagingPreprint

Long, E. A., Simkulet, M. G., Tang, R. P., Jiang, J., Erdener, Ş. E., O’Shea, T. M., Boas, D. A., & Cheng, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.02.713027

Glucose signaling through Snf1/AMPK in Saccharomyces cerevisiae : mechanistic insights from 2-deoxyglucose-resistant mutants

Ballin, A. (2025) · theses.fr (ABES) · doi:10.70675/731be029z5e78z4c78z8ad3zad902ee758ea

Glycolytic Inhibition may not be a Pathway for Covid-19 Inhibition of 2-Deoxyglucose: Evidence from Computational Studies

Pooventhiran, T., Kasparraj, J. S., Khairbek, A. A., Murthy, K. R. S., & Thomas, R. (2026) · Letters in Applied NanoBioScience · doi:10.33263/lianbs151.048

TORC1 integrates metabolic state transitions during agingPreprint

Cheng, T. Y. N., Naaz, A., 高铭彤, Hao, W., Zhang, Y., Cui, L., Lin, J. J., Yogasundaram, S., Faidzinn, N. A., Victoria, O. Y. Q., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.18.726092

UNDERSTANDING THE ROLE OF SUMOYLATION IN REGULATING LKB1 FUNCTION

Ritho, J. (2015) · Digital Commons-TMC (Texas Medical Center)

Microbial metabolism of 2-deoxyglucose

Eichhorn, M. M., & Cynkin, M. A. (1964) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(64)90037-6 · Cited by 6

Proceedings: Metabolism of 2-deosy-D-glucose in tissue culture cells.

Mf, S., Rt, S., & Scholtissek, C. (1974) · PubMed

THE EFFECT OF 2-DEOXYGLUCOSE ON THE METABOLISM OF GLUCOSE, FRUCTOSE, AND GALACTOSE BY RAT DIAPHRAGM

Nakada, H. I., & Wick, A. N. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89925-6 · Cited by 28

A study of gluconeogenesis by the administration of 2-deoxyglucose. II

Friedmann, N. K., & Wertheimer, H. E. (1966) · Metabolism · doi:10.1016/0026-0495(66)90020-5 · Cited by 2

METABOLISM OF GALACTOSE

Harding, V. J., & Grant, G. A. (1933) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)76056-0 · Cited by 47