The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE
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“2-DG is phosphorylated by hexokinase to produce 2-deoxyglucose-6-phosphate, which cannot be further metabolized by cells. It therefore accumulates intracellularly and competitively inhibits hexokinase to slow glucose uptake (Figure 3).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Wick et al., 1957
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Metadata
- Authors
- Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R.
- Affiliations
- Scripps Clinic (US)
- ORCID
- Wick, Arne N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1957-02
- Volume
- 224
- Issue
- 2
- Pages
- 963-969
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1536070820
- Cited by
- 780
- References
- 13
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 24 · 2022: 27 · 2021: 27 · 2020: 33 · 2019: 37 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 24 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- 2-deoxyglucose, metabolic block, glycolysis inhibition, glucose metabolism, enzyme localization, glycolytic enzymes
- MeSH terms
- Deoxyglucose, Glucose, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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