LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE

The Determination of Enzyme Dissociation Constants

Lineweaver, H., & Burk, D. (1934) · Journal of the American Chemical Society · doi:10.1021/ja01318a036 · Cited by 12,031

A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETECTION AND DETERMINATION OF KETO SUGARS AND TRIOSES

Dische, Z., & Borenfreund, E. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77782-5 · Cited by 1,108

SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE

Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 599

The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues.

Woodward, G. E., & Hudson, M. T. (1954) · PubMed · Cited by 158

2-Desoxy-D-glucose as an antagonist of glucose in yeast fermentation

Cramer, F. B., & Woodward, G. E. (1952) · Journal of the Franklin Institute · doi:10.1016/0016-0032(52)90852-1 · Cited by 123

SUGAR UTILIZATION IN EVISCERATED RABBITS

Drury, D. R. (1935) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1935.111.2.289 · Cited by 107

The Action of Ammonia on Allophanic Azide

LIPSCHITZ, W. L. (1944) · Journal of the American Chemical Society · doi:10.1021/ja01232a510 · Cited by 54

2-Deoxyglucose--A Metabolic Block for Glucose.

Wick, A. N., Drury, D. R., & Morita, T. N. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-89-21881 · Cited by 41

Über die ungesättigten Reduktionsprodukte der Zuckerarten und ihre Umwandlungen, III.: Über 2‐Desoxyglucose (Gluco‐desose)

Bergmann, M. F., Schotte, H., & Lechinsky, W. (1922) · Berichte der deutschen chemischen Gesellschaft (A and B Series) · doi:10.1002/cber.19220550122 · Cited by 41

The effect of 6-deoxy-6-fluoro-d-glucose on yeast fermentation and on hexokinase

Blakley, E. R., & Boyer, P. D. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90281-x · Cited by 32

EFFECT OF GLUCAGON ON INSULIN RELEASE IN VITRO

Devrim, S., & Recant, L. (1966) · The Lancet · doi:10.1016/s0140-6736(66)92307-5 · Cited by 51

The Distribution and Utilization of Glucose in Isolated Lymph Node Cells

HELMREICH, E. J. M., & Eisen, H. N. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69849-7 · Cited by 52

Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters

Prax, M., Mechler, L., Weidenmaier, C., & Bertram, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150907 · Cited by 50

Metabolism Regulates the Spontaneous Firing of Substantia Nigra Pars Reticulata Neurons via KATPand Nonselective Cation Channels

Lutas, A., Birnbaumer, L., & Yellen, G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-14.2014 · Cited by 50

Hungry Neurons: Metabolic Insights on Seizure Dynamics

Bazzigaluppi, P., Amini, A. E., Weisspapir, I., Stefanovic, B., & Carlen, P. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112269 · Cited by 54

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Koenig, J. B., Cantu, D., Low, C., Sommer, M., Noubary, F., Croker, D., Whalen, M. J., Kong, D., & Dulla, C. G. (2019) · JCI Insight · doi:10.1172/jci.insight.126506 · Cited by 50

Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma

Pruss, M., Dwucet, A., Tanriover, M., Hlaváč, M., Kast, R. E., Debatin, K., Wirtz, C. R., Halatsch, M., Siegelin, M. D., Westhoff, M., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0759-0 · Cited by 51

2-Deoxy-D-Glucose and its Derivatives for the COVID-19 Treatment: An Update

Huang, Z., Chavda, V. P., Vora, L. K., Gajjar, N. D., Apostolopoulos, V., Shah, N., & Chen, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.899633 · Cited by 51

Fourth ventricular phlorizin dissociates feeding from hyperglycemia in rats

Flynn, F. W., & Grill, H. J. (1985) · Brain Research · doi:10.1016/0006-8993(85)91072-8 · Cited by 50

The inhibition of phosphoglucose isomerase by D-erythrose 4-phosphate

Grazi, E., FLORA, A. D., & Pontremoli, S. (1960) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(60)90201-1 · Cited by 50

The relationship between CNS metabolism and cytoarchitecture: A review of 14C-deoxyglucose studies with correlation to cytochrome oxidase histochemistry

Rocco, R. J. D., Kageyama, G. H., & Wong-Rile, M. T. T. (1989) · Computerized Medical Imaging and Graphics · doi:10.1016/0895-6111(89)90080-3 · Cited by 50

Effects of 2-deoxy-d-glucose, amiloride, vasopressin, and ouabain on active conductance andE Na in the toad bladder

Hong, C. D., & Essig, A. (1976) · The Journal of Membrane Biology · doi:10.1007/bf01869693 · Cited by 50

Reduced glucose transport and increased binding of insulin in adipocytes from diabetic and fasted rats

Wieringa, T., & Krans, H. M. J. (1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90417-8 · Cited by 50

Stages in phage R17 infection

PARANCHYCH, W., Krahn, P. M., & Bradley, R. (1970) · Virology · doi:10.1016/0042-6822(70)90168-6 · Cited by 49

The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.

Kaplan, O., Jaroszewski, J. W., Clarke, R. C., Fairchild, C. R., Schoenlein, P. V., Goldenberg, S., Gottesman, M. M., & Cohen, J. S. (1991) · PubMed · Cited by 49

Glycolytic flux controls d -serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

Suzuki, M., Sasabe, J., Miyoshi, Y., Kuwasako, K., Muto, Y., Hamase, K., Matsuoka, M., Imanishi, N., & Aiso, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416117112 · Cited by 54

2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control

Rho, J. M., Shao, L.-R., & Stafstrom, C. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00172 · Cited by 52

C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages

Newling, M., Sritharan, L., van der Ham, A. J., Hoepel, W., Fiechter, R. H., de Boer, L., Zaat, S. A. J., Bisoendial, R. J., Baeten, D., Everts, B., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900172 · Cited by 52

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines

Martin, S. D., & McGee, S. L. (2019) · Cancer & Metabolism · doi:10.1186/s40170-019-0207-x · Cited by 48

2-Deoxy-D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis

Bell, S., Quinn, D., Kellett, G. L., & Warr, J. R. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.708 · Cited by 48

Intracellular Glucopenia Causes Prolactin Release in Man

Woolf, P. D., Lee, L. A., Leebaw, W. F., Thompson, D. A., Lilavivathana, U., Brodows, R. G., & Campbell, R. G. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-3-377 · Cited by 48

Glycolysis–respiration relationships in a neuroblastoma cell line

Swerdlow, R. H., Lezi, E., Aires, D., & Lu, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.002 · Cited by 47

The effect of metabolic fuel availability on thermoregulation and torpor in a marsupial hibernator

Westman, W., & Geiser, F. (2004) · Journal of Comparative Physiology B · doi:10.1007/s00360-003-0388-y · Cited by 47

The Insulin-Sensitive Hexose Transport System in Adipocytes

Gliemann, J., & Rees, W. D. (1983) · Current topics in membranes and transport · doi:10.1016/s0070-2161(08)60536-5 · Cited by 47

On the Biochemical Nature of Triose- and Hexose- Stimulated Insulin Secretion*

Zawalich, W. S., DYE, E. S., Rognstad, R., & Matschinsky, F. M. (1978) · Endocrinology · doi:10.1210/endo-103-6-2027 · Cited by 46

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

Hall, D. J., Grewal, S., de la Cruz, A. F. A., & Edgar, B. A. (2007) · BMC Biology · doi:10.1186/1741-7007-5-10 · Cited by 46

Escape deficits induced by inescapable shock and metabolic stress are reversed by adenosine receptor antagonists

Minor, T. R., Rowe, M. K., Job, R. F. S., & Ferguson, E. C. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00376-4 · Cited by 46

Glucose transport in osteoblast-enriched bone explants: Characterization and insulin regulation

Hahn, T. J., Westbrook, S., Sullivan, T. L., Goodman, W. G., & Halstead, L. R. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030317 · Cited by 47

Placental Transfer of Analogs of Glucose and Amino Acids in Experimental Intrauterine Growth Retardation

Nitzan, M., Orloff, S., & Schulman, J. D. (1979) · Pediatric Research · doi:10.1203/00006450-197902000-00003 · Cited by 46

Research into cancer metabolomics: Towards a clinical metamorphosis

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., & Halsey, C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.008 · Cited by 45

Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs

Ždralević, M., Marchiq, I., de Padua, M. M. C., Parks, S. K., & Pouysségur, J. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00313 · Cited by 45

C1 Oxidation/C2 Reduction Isomerization of Unprotected Aldoses Induced by Light/Ketone

Masuda, Y., Tsuda, H., & Murakami, M. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201914242 · Cited by 45

Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat

Sakata, T., Tsutsui, K., Fukushima, M., Arase, K., Kita, H., Oomura, Y., Ohki, K., & Nicolaı̈dis, S. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90323-1 · Cited by 45

Interference of Nucleoside Diphosphate Derivatives of 2-Deoxy-d-glucose with the Glycosylation of Virus-Specific Glycoproteins in vivo

Schmidt, M. F. G., Schwarz, R. Τ., & Scholtissek, C. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10955.x · Cited by 45

2‐Deoxy‐ d ‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA A receptors

Forte, N. R., Medrihan, L., Cappetti, B., Baldelli, P., & Benfenati, F. (2016) · Epilepsia · doi:10.1111/epi.13578 · Cited by 44

Mild metabolic perturbations alter succinylation of mitochondrial proteins

Chen, H., Xu, H., Potash, S., Starkov, A. A., Belousov, V. V., Bilan, D. S., Denton, T. T., & Gibson, G. E. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24103 · Cited by 43

AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation

Sutter, T. R., Olesen, K. M., Bhuju, J., Guo, Z., & Sutter, T. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.019 · Cited by 46

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

Tan, S. Y., Kelkar, Y., Hadjipanayis, A. G., Shipstone, A., Wynn, T. A., & Hall, J. P. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000137 · Cited by 46

The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis

Tu, L., Fukuda, M., Tong, Q., & Xu, Y. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00799-2 · Cited by 50

Formation of Dolichol Monophosphate 2‐Deoxy‐ d ‐glucose and Its Interference with the Glycosylation of Mannoproteins in Yeast

LEHLF, L., & Schwarz, R. Τ. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10655.x · Cited by 44

Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells

Melcher, M., Danhauser, K., Seibt, A., Degistirici, Ö., Baertling, F., Kondadi, A. K., Reichert, A. S., Koopman, W. J. H., Willems, P. H. G. M., Rodenburg, R. J., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0601-7 · Cited by 47

Higher Glucose Enhances Breast Cancer Cell Aggressiveness

Santos, J. M., & Hussain, F. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1654527 · Cited by 42

Rat pancreatic level of cystathionine γ-lyase is regulated by glucose level via specificity protein 1 (SP1) phosphorylation

Zhang, L., Yang, G., Tang, G., Wu, L., & Wang, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2187-4 · Cited by 43

Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Harada, Y., Nakajima, K., Suzuki, T., Fukushige, T., Kondo, K., Seino, J., Ohkawa, Y., Suzuki, T., Inoue, H., Kanekura, T., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108261 · Cited by 42

Effects of photoperiod and 2-deoxy-D-glucose-induced metabolic stress on immune function in female deer mice

Demas, G. E., DeVries, A. C., & Nelson, R. J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1762 · Cited by 42

Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-β: Selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression

Yuan, W., Collado-Hidalgo, A., Yufit, T., Taylor, M. W., & Varga, J. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199810)177:1 · Cited by 85

2-deoxy-D-glucose-induced decrements in operant and reflex pain thresholds

Bodnar, R. J., Kelly, D. D., Brutus, M., Mansour, A., & Glusman, M. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90056-4 · Cited by 43

Glucose Antimetabolites and Hunger

Rezek, M., & Kroeger, E. A. (1976) · Journal of Nutrition · doi:10.1093/jn/106.2.143 · Cited by 42

Central, But Not Peripheral, Glucose-Sensing Mechanisms Mediate Glucoprivic Suppression of Pulsatile Luteinizing Hormone Secretion in the Sheep**This work was supported by the U.S.-Japan Cooperative Science Program from NSF (National Science Foundation) and JSPS (Japan Society for the Promotion of Science) (INT-9603310); a grant-in-aid for International Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan (Joint Research 09044215); and research grants from the NIH (HD-18258 and HD-18394). A preliminary report of this work was presented at the 29th Annual Meeting of the Society for Neuroscience, Miami Beach, FL, October 1999 (Abstract 166.13).

Ohkura, S., TANAKA, T., Nagatani, S., Bucholtz, D. C., Tsukamura, H., Maeda, K., & Foster, D. L. (2000) · Endocrinology · doi:10.1210/endo.141.12.7853 · Cited by 41

2-Deoxyglucose Transport and Phosphorylation by Bovine Sperm1

Hiipakka, R. A., & Hammerstedt, R. H. (1978) · Biology of Reproduction · doi:10.1095/biolreprod19.2.368 · Cited by 41

Neuropeptide Y induces torpor-like hypothermia in Siberian hamsters

Paul, M. J., Freeman, D. A., Park, J., & Dark, J. G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.090 · Cited by 44

Galanin Injection into the Nucleus of the Solitary Tract Stimulates Feeding in Rats with Lesions of the Paraventricular Nucleus of the Hypothalamus

Koegler, F. H., & Ritter, S. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00480-0 · Cited by 41

GLUCOPRIVATION AND THE GLUCOPRIVIC CONTROL OF FOOD INTAKE

Ritter, S. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-589060-1.50014-6 · Cited by 41

Alternative pathways of carbohydrate metabolism in foetal and adult tissues

VILLEE, C., & Loring, J. M. (1961) · Biochemical Journal · doi:10.1042/bj0810488 · Cited by 41

Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability

Yi, Y., Chen, D., Ao, J., Sun, S., Wu, M. C., Li, X., Bergholz, J. S., Zhang, Y., & Xiao, Z. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.769141 · Cited by 40

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

Moede, T., Leibiger, B., Sánchez, P. V., Daré, E., Köhler, M. G., Muhandiramlage, T. P., Leibiger, I. B., & Berggren, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-76863-z · Cited by 41

Inhibitory effect of 2-deoxy-D-glucose on liver tumor growth in rats.

Cay, O., Radnell, M., Jeppsson, B. W., Åhrén, B., & Bengmark, S. (1992) · PubMed · Cited by 40

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma

Levy, A. G., Zage, P. E., Akers, L. J., Ghisoli, M. L., Chen, Z., Fang, W., Kannan, S., Graham, T. C., Zeng, L., Franklin, A. R. K., et al. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9551-y · Cited by 40

Glucose is a pH-Dependent Motor for Sperm Beat Frequency during Early Activation

Mannowetz, N., Wandernoth, P. M., & Wennemuth, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041030 · Cited by 40

Chronic 2-deoxy-D-glucose treatment: Adaptation of its analgesic, but not hyperphagic properties

Bodnar, R. J., Kelly, D. D., Brutus, M., & Glusman, M. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90354-4 · Cited by 40

Glucose transporters and transport kinetics in retinoic acid-differentiated T47D human breast cancer cells

Rivenzon‐Segal, D., Rushkin, E., Polak‐Charcon, S., & Degani, H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e508 · Cited by 39

A novel ex vivo method for measuring whole brain metabolism in model systems

Neville, K. E., Bosse, T. L., Klekos, M., Mills, J. F., Weicksel, S. E., Waters, J. S., & Tipping, M. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.12.020 · Cited by 39

FcγR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming

Hoepel, W., Newling, M., Vogelpoel, L. T. C., Sritharan, L., Hansen, I. S., Kapsenberg, M. L., Baeten, D., Everts, B., & den Dunnen, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00739 · Cited by 39

Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice

Li, M., Li, L., Li, B., Hambly, C., Wang, G., Wu, Y., Jin, Z., Wang, A., Niu, C., Wolfrum, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24659-8 · Cited by 42

Examination of Potential Mechanisms in the Enhancement of Cerebral Blood Flow by Hypoglycemia and Pharmacological Doses of Deoxyglucose

Horinaka, N., Artz, N., Jehle, J. W., Takahashi, S., Kennedy, C., & Sokoloff, L. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199701000-00008 · Cited by 39

Adrenal demedullation blocks and brain norepinephrine depletion potentiates the hyperglycemic response to a variety of stressors

Bialik, R. J., Smythe, J. W., Sardelis, M., & Roberts, D. C. S. (1989) · Brain Research · doi:10.1016/0006-8993(89)90464-2 · Cited by 39

Effect of inhibitors of carbohydrate metabolism on the development of preimplantation mouse embryos

Thomson, J. L. (1967) · Experimental Cell Research · doi:10.1016/0014-4827(67)90063-8 · Cited by 39

The influence of 2-deoxy-d-glucose on the nucleotide content of ehrlich ascites carcinoma cells

Letnansky, K. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects · doi:10.1016/0926-6550(64)90040-4 · Cited by 39

Stereoselective effects of opiate agonists and antagonists on ingestive behavior in rats.

Lowy, M., Starkey, C., & Yim, G. K. W. (1981) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(81)90215-x · Cited by 39

The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation

Bentley, J. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04739-3 · Cited by 38

The role of the cytoplasmic redox potential in the control of fatty acid synthesis from glucose, pyruvate and lactate in white adipose tissue

Halperin, M. L., & Robinson, B. H. (1970) · Biochemical Journal · doi:10.1042/bj1160235 · Cited by 38

Activity of single neurons in the hypothalamic feeding centers: Effect of 2-deoxy-d-glucose

Desiraju, T., Banerjee, M. G., & Anand, B. K. (1968) · Physiology & Behavior · doi:10.1016/0031-9384(68)90148-0 · Cited by 38

An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

Traba, J., Miozzo, P., Akkaya, B., Pierce, S. K., & Akkaya, M. (2016) · Journal of Visualized Experiments · doi:10.3791/54918 · Cited by 37

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease

Weimbs, T., Shillingford, J. M., Torres, J. A., Kruger, S. L., & Bourgeois, B. C. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy089 · Cited by 37

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Zhu, J., Wang, G., Huang, X., Lee, H., Lee, J., Yang, P., van de Leemput, J., Huang, W., Kane, M. A., Yang, P., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03986-6 · Cited by 37

1,5-Anhydro-d-glucitol 6-phosphate and its use for the specific inhibition of the hexokinase reaction in tissue homogenates

Ferrari, R. A., Mandelstam, P., & Crane, R. K. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90264-4 · Cited by 37

Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake

Chang, M., Hamilton, J. A., Scholz, G. M., Masendycz, P. J., Macaulay, S. L., & Elsegood, C. L. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.04.003 · Cited by 39

Characterization of a mutant human insulin species.

Olefsky, J. M., Saekow, M., Tager, H. S., & Rubenstein, A. H. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43706-4 · Cited by 36

Interferon‐γ/lipolysaccharide‐treated mouse embryonic fibroblasts are killed by a glycolysis/ l ‐arginine‐dependent process accompanied by depression of mitochondrial respiration

Dijkmans, R., & Billiau, A. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16356.x · Cited by 36

Incorporation of [3H]2-deoxyglucose into glycogen in nervous tissues

Pentreath, V. W., Seal, L. H., & Kai-Kai, M. A. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90081-1 · Cited by 36

Glycerol and testicular activity: the good, the bad and the ugly

Crisóstomo, L., Alves, M. G., Calamita, G., Sousa, M., & Oliveira, P. F. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax049 · Cited by 35

Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1α

Diers, A. R., Vayalil, P. K., Oliva, C. R., Griguer, C. E., Darley-Usmar, V. M., Hurst, D. R., Welch, D. R., & Landar, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068348 · Cited by 34

Warburg and Krebs and related effects in cancer

Unterlass, J. E., & Curtin, N. J. (2019) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2019.4 · Cited by 35

The effects of pharmacologic doses of 2-deoxy-d-glucose on local cerebral blood flow in the awake, unrestrained rat

Breier, A. F., Crane, A. M., Kennedy, C., & Sokoloff, L. (1993) · Brain Research · doi:10.1016/0006-8993(93)91276-x · Cited by 34

2-Deoxy-d-glucose and Mercaptoacetate Induce Different Patterns of Macronutrient Ingestion

Ritter, S., Ritter, J. B., & Cromer, L. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00009-8 · Cited by 34

Metabolic effects of 2-deoxy-D-glucose in isolated fat cells

Chandramouli, V., & Carter, J. R. (1977) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(77)90310-5 · Cited by 34

Increased Thirst and Plasma Arginine Vasopressin Levels during 2-Deoxy-d-glucose-induced Glucoprivation in Humans

Thompson, D. A., Campbell, R. G., Lilavivat, U., Welle, S. L., & Robertson, G. L. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110121 · Cited by 34

Influence of energy metabolism on the repair of X-ray damage in living cells

Jain, V., Pohlit, W., & Purohit, S. C. (1973) · Radiation and Environmental Biophysics · doi:10.1007/bf01191239 · Cited by 34

GENETIC STUDY OF HUMAN CELLS IN VITRO

Chang, R. S. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.111.2.235 · Cited by 34

Long-term calibration considerations during subcutaneous microdialysis sampling in mobile rats

Mou, X., Lennartz, M. R., Loegering, D. J., & Stenken, J. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.016 · Cited by 33

Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy

Frlic, T., & Pavlin, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1688995 · Cited by 38

G6Pase location in the endoplasmic reticulum: Implications on compartmental analysis of FDG uptake in cancer cells

Scussolini, M., Bauckneht, M., Cossu, V., Bruno, S., Orengo, A. M., Piccioli, P., Capitanio, S., Yosifov, N., Ravera, S., Morbelli, S. D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38973-1 · Cited by 33

Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis

Hsieh, Y.-T., Chen, Y., Lin, S., Chang, K., & Li, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163960 · Cited by 33

METABOLIC SUBSTRATE ENGINEERING AS A TOOL FOR GLYCOBIOLOGY

Goon, S., & Bertozzi, C. R. (2002) · Journal of Carbohydrate Chemistry · doi:10.1081/car-120016493 · Cited by 33

Photoperiod Modulates Torpor and Food Intake in Siberian Hamsters Challenged With Metabolic Inhibitors

Stamper, J. L., Dark, J. G., & Zucker, I. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00283-2 · Cited by 33

Central glucoprivation: Some physiological effects induced by the intraventricular administration of 2-deoxy-d-glucose

Müller, E. E., Panerai, A., Cocchi, D., Frohman, L. A., & Mantegazza, P. (1973) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946338 · Cited by 33

Metabolic and neurochemical correlates of glucoprivic feeding

Rowland, N. E., Bellush, L. L., & Carlton, J. R. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90111-x · Cited by 33

The biosynthesis of patulin

Tanenbaum, S. W., & Bassett, E. W. (1958) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(58)90422-0 · Cited by 33

ON THE ROLE OF CYCLIC AMP IN INSULIN RELEASE: I. OVERALL EFFECTS IN CULTURED FETAL RAT PANCREAS*

Lambert, A. E., Kanazawa, Y., Burr, I. M., Orci, L., & Renold, A. E. (1971) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1971.tb45252.x · Cited by 33

A comparison of the effects of metabolic inhibitors upon direct and antibody-dependent lymphocyte mediated cytotoxicity

Strom, T. B., Garovoy, M. R., Bear, R. A., Gribik, M., & Carpenter, C. B. (1975) · Cellular Immunology · doi:10.1016/0008-8749(75)90102-1 · Cited by 33

Microbial metabolism of 2-deoxyglucose

Eichhorn, M. M., & Cynkin, M. A. (1964) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(64)90037-6 · Cited by 6

Proceedings: Metabolism of 2-deosy-D-glucose in tissue culture cells.

Mf, S., Rt, S., & Scholtissek, C. (1974) · PubMed

THE EFFECT OF 2-DEOXYGLUCOSE ON THE METABOLISM OF GLUCOSE, FRUCTOSE, AND GALACTOSE BY RAT DIAPHRAGM

Nakada, H. I., & Wick, A. N. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89925-6 · Cited by 28

A study of gluconeogenesis by the administration of 2-deoxyglucose. II

Friedmann, N. K., & Wertheimer, H. E. (1966) · Metabolism · doi:10.1016/0026-0495(66)90020-5 · Cited by 2

METABOLISM OF GALACTOSE

Harding, V. J., & Grant, G. A. (1933) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)76056-0 · Cited by 47