The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides.
Open accessAbstract
Binding of a series of mammalian glycoconjugates to three soluble rat lung lectins was determined with a quantitative assay. The three lectins, RL-14.5, RL-18, and RL-29, had a similar apparent affinity for lactose and associated with the same critical determinants, which included positions 4 and 6 of Gal and part of Glc. Derivatization at position 3 of Glc in lactose markedly reduced reactivity with the three lectins. For RL-14.5 and RL-29 the determinant extended specifically to the 3-hydroxyl of Glc which must be equatorial. In contrast, the stereochemical requirements for RL-18 were less specific, and Gal beta 1-3GalNAc bound as well as lactose. For RL-29 activity was markedly enhanced by GalNAc alpha 1-3 substitution on Gal, a modification which had little effect with RL-18 and inhibited binding to RL-14.5. Combinations of these residues in larger oligosaccharides and glycopeptides did not substantially enhance binding above that which might be expected from the sum of the constituent beta-galactoside residues. Although these lectins showed overlapping specificities, their binding properties are sufficiently different to suggest selective interactions with naturally occurring mammalian glycoconjugates.
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Morrissey, J. H. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90783-1 · Cited by 4,061
Bolton, A. E., & Hunter, W. M. (1973) · Biochemical Journal · doi:10.1042/bj1330529 · Cited by 3,254
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914
Feizi, T. (1985) · Nature · doi:10.1038/314053a0 · Cited by 1,181
Lee, Y. C., Townsend, R. R., Hardy, M. R., Lönngren, J., Arnarp, J., Haraldsson, M., & Lönn, H. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33240-x · Cited by 503
Fournet, B., Montreuil, J., Strecker, G., Dorland, L., Haverkamp, J., Vliegenthart, J. F. G., Binette, J. P., & Schmid, K. (1978) · Biochemistry · doi:10.1021/bi00617a021 · Cited by 421
Soluble Lectins: A New Class of Extracellular Proteins
Barondes, S. H. (1984) · Science · doi:10.1126/science.6367039 · Cited by 415
Self-citationStructural studies on the carbohydrate portion of fetuin.
Nilsson, B., Nordén, N. E., & Svensson, S. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30046-7 · Cited by 352
Bock, K., Breimer, M. E., Brignole, A., Hansson, G. C., Karlsson, K. A., Larson, G., Leffler, H., Samuelsson, B. E., Strömberg, N., & Edén, C. S. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39507-8 · Cited by 293
Self-citationA beta-D-galactoside binding protein from electric organ tissue of Electrophorus electricus.
Teichberg, V. I., Silman, I., Beitsch, D. D., & Resheff, G. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.4.1383 · Cited by 288
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Barondes, S. H. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90235-6 · Cited by 334
Self-citationSato, S., & Hughes, R. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50525-7 · Cited by 270
Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation
Singh, H., & Aplin, J. D. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01034.x · Cited by 189
Identification of a galactose-binding lectin on Fusobacterium nucleatum FN-2
Murray, P. A., Kern, D. G., & Winkler, J. R. (1988) · Infection and Immunity · doi:10.1128/iai.56.5.1314-1319.1988 · Cited by 59
Metadata
- Authors
- Leffler, H., & Barondes, S. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-08
- Volume
- 261
- Issue
- 22
- Pages
- 10119-10126
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1567285907
- Cited by
- 296
- References
- 29
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Leffler, H., & Barondes, S. H. (1986). Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)67499-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
