Cited by 189Reproductive System and PregnancyCell Adhesion Molecules ResearchReproductive Biology and Fertility

Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation

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Singh, Harmeet, Aplin, John D.·2009·Journal of Anatomy

Abstract

Cell adhesion in endometrial epithelium is regulated to maintain the continuity and protectiveness of the luminal covering cell layer while permitting interstitial implantation of the embryo during a restricted period of about 4 days. Many apparently normal embryos fail to implant, and epithelial‐embryo adhesion remains a poorly understood phenomenon. After menstruation, epithelial regeneration occurs by epiboly from the basal residues of glands, an activity that requires migration on extracellular matrix as well as cell–cell cohesion. Here we review current knowledge of adhesion molecules in the epithelium.

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Integrity signals

Registry

Crossref · 10.1111/j.1469-7580.2008.01034.x

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  • IGSF21, along with other members of the IGSF superfamily, has functions linked to endometriosis.

    “The IGSF21, along with other members of the IGSF superfamily, has functions linked to endometriosis.”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [39]

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Research works printed but not linked: 1

  1. Jones CJ, Aplin JD (2004) Glycans as attachment and signalling molecules at the maternal-fetal interface. In Signalling molecules in Animal and Human Gestation (ed. Paulesu LR), pp. 65-86. Trivandrum: Research Signpost.

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Authors
Singh, H., & Aplin, J. D.
Affiliations
University of Manchester (GB)
Venue
Journal of Anatomy
Publisher
Wiley
Published
2009-06-22
Volume
215
Issue
1
Pages
3-13
ISSN
  • 0021-8782 (ISSN-L)
  • 1469-7580
OpenAlex
W2143108062
Cited by
189
References
178
Citations by year
2026: 7 · 2025: 15 · 2024: 10 · 2023: 16 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 5 · 2014: 20 · 2013: 12 · 2012: 9
FWCI
0.60
Type
journal article
Language
en
Open access
Locations
  • Journal of Anatomy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
endometrial epithelium, adhesion molecules, embryo implantation, endometrial regeneration, epiboly, extracellular matrix, cell migration, cell-cell adhesion, tissue integrity
MeSH terms
Endometrium, Epithelium, Female, Humans, Immunoglobulins, Embryo Implantation, Cell Adhesion Molecules, Cadherins, Integrins

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