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Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.
Open accessAbstract
In the primary structure of protein kinase C, the presence of a putative metal-binding site has been suggested (Parker, P.J., Coussens, L., Totty, N., Rhee, L., Young, S., Chen, E., Stabel, S., Waterfield, M.D., and Ullrich, A. (1986) Science 233, 853-859). In the present report, we demonstrate that the most abundant intracellular heavy metal, zinc, can increase the activity of cytosolic protein kinase C. Zinc reversibly binds the enzyme to plasma membranes, and it may contribute to the calcium-induced binding as well. The intracellular heavy metal chelator N,N,N',N'-tetrakis(2-pyridylmethyl) ethylenediamine prevents the phorbol ester- and antigen-induced translocation of protein kinase C. This effect can be totally reversed by the concomitant addition of Zn2+, while Fe2+ and Mn2+ are only partially counteractive. Our results suggest that zinc can activate protein kinase C and contributes to its binding to plasma membranes in T lymphocytes induced by Ca2+, phorbol ester, or antigen.
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Cited by
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
Noh, K.-M., & Koh, J.-Y. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-j0001.2000 · Cited by 332
Maywald, M., Wessels, I., & Rink, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102222 · Cited by 309
Zinc signals and immune function
Haase, H., & Rink, L. (2014) · BioFactors · doi:10.1002/biof.1114 · Cited by 297
Zinc-Altered Immune Function and Cytokine Production
Rink, L., & Kirchner, H. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1407s · Cited by 271
Metadata
- Authors
- Csermely, P., Szamel, M., Resch, K., & Somogyi, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 263
- Issue
- 14
- Pages
- 6487-6490
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2116954627
- Cited by
- 187
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Csermely, P., Szamel, M., Resch, K., & Somogyi, J. (1988). Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68668-5
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