The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Zinc signals and immune function
Abstract
For more than 50 years, it has been known that zinc deficiency compromises immune function. During this time, knowledge about the biochemistry of zinc has continued to grow, but only recent years have provided in‐depth molecular insights into the multiple aspects of zinc as a regulator of immunity. A network based on ZnT and ZIP proteins for transport and metallothionein for storage tightly regulates zinc availability, and virtually all aspects of innate and adaptive immunity are affected by zinc. In vivo, zinc deficiency alters the number and function of neutrophil granulocytes, monocytes, natural killer (NK)‐, T‐, and B‐cells. T cell functions and balance between the different subsets are particularly susceptible to changes in zinc status. This article focuses in particular on the main mechanisms by which zinc ions exert essential functions in the immune system. On the one hand, this includes tightly protein bound zinc ions serving catalytic or structural functions in a multitude of different proteins, in particular enzymes and transcription factors. On the other hand, increasing evidence arises for a regulatory role of free zinc ions in signal transduction, especially in cells of the immune system. Identification of several molecular targets, including phosphatases, phosphodiesterases, caspases, and kinases suggest that zinc ions are a second messenger regulating signal transduction in various kinds of immune cells. © 2013 BioFactors, 40(1):27–40, 2014
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Zinc and its role in immunity and inflammation
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Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
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Metadata
- Authors
- Haase, H., & Rink, L.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2013-06-27
- Volume
- 40
- Issue
- 1
- Pages
- 27-40
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W1574329348
- Cited by
- 297
- References
- 201
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- closed
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