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Feedback Control of Mevalonate Synthesis by Dietary Cholesterol
Open accessAbstract
1. By means of a gas-liquid chromatographic technique the effect of exogenous cholesterol on the incorporation of acetate-2-14C into β-hydroxy-β-methylglutarate and mevalonate has been measured both in cell-free systems of liver and in intact liver cells. 2. It has been shown that mevalonate synthesis is markedly suppressed by cholesterol feeding while the synthesis of β-hydroxy-β-methylglutarate is unaffected by this regimen. These results are consistent with the conclusion that the major site of the cholesterol feedback system is located at the reaction responsible for the conversion of β-hydroxy-β-methylglutarate to mevalonate; namely β-hydroxy-β-methylglutaryl reductase. 3. The intracellular localization of mevalonate synthesis and its feedback control have been likewise examined. Mevalonate was found to be synthesized in both microsomal and soluble fractions of the liver cell; however, the major site of mevalonate synthesis, and hence of feedback control of cholesterol synthesis, is localized to the membranous fraction of the microsomes.
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Citations
Cited by
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
The discovery and development of HMG-CoA reductase inhibitors.
Endo, A. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41379-3 · Cited by 847
Regulation of Cholesterol Metabolism
Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005142822005 · Cited by 361
Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat
Dietschy, J. M., & Siperstein, M. D. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38921-5 · Cited by 296
Self-citationLavrnja, I., Smiljanic, K., Savic, D., Mladenovic-Djordjevic, A., Tesovic, K., Kanazir, S., & Pekovic, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02638-8 · Cited by 54
Metadata
- Authors
- Siperstein, M. D., & Fagan, V. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1966-02
- Volume
- 241
- Issue
- 3
- Pages
- 602-609
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1562982017
- Cited by
- 330
- References
- 0
- FWCI
- 47.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Siperstein, M. D., & Fagan, V. M. (1966). Feedback Control of Mevalonate Synthesis by Dietary Cholesterol. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)96879-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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