Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

New Perspectives in Cell Adhesion: RGD and Integrins

Ruoslahti, E. I., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,875

Integrins: A family of cell surface receptors

Hynes, R. O. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,258

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

Hemler, M. E. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.002053 · Cited by 1,561

Integrins.

Ruoslahti, E. I. (1991) · Journal of Clinical Investigation · doi:10.1172/jci114957 · Cited by 1,391

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

Oldberg, Å., Franzén, A., & Heinegård, D. K. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.8819 · Cited by 1,081

Bone and Mineral Research

(1990) · Elsevier eBooks · doi:10.1016/c2009-0-34738-8 · Cited by 1,073

Osteopontin--a possible anchor of osteoclasts to bone.

Reinholt, F. P., Hultenby, K. R., Oldberg, Å., & Heinegård, D. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4473 · Cited by 831

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

Lawler, J., & Hynes, R. O. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.5.1635 · Cited by 580

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

Cheresh, D. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6471 · Cited by 569

Structure and biology of cartilage and bone matrix noncollagenous macromolecules

Heinegård, D. K., & Oldberg, Å. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.9.2663581 · Cited by 567

Bone Sialoprotein Mediates Human Endothelial Cell Attachment and Migration and Promotes Angiogenesis

Bellahcène, A., Bonjean, K., Fohr, B., Fedarko, N. S., Robey, F. A., Young, M. F., Fisher, L. W., & Castronovo, V. (2000) · Circulation Research · doi:10.1161/01.res.86.8.885 · Cited by 127

Cloning of the promoter for the avian integrin beta 3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3.

Cao, X., Ross, F. P., Zhang, L., MacDonald, P. N., Chappel, J. C., & Teitelbaum, S. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74259-8 · Cited by 126

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment

Reichert, J. C., Quent, V. M. C., Burke, L. J., Stansfield, S. H., Clements, J. A., & Hutmacher, D. W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.055 · Cited by 125

Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid

Matsumoto, T., Okazaki, M., Inoue, M., Hamada, Y., Taira, M., & Takahashi, J. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00358-1 · Cited by 124

Peptide Ligands for Integrin .alpha.v.beta.3 Selected from Random Phage Display Libraries

Healy, J. M., Murayama, O., Maeda, T., Yoshino, K., Sekiguchi, K., & Kikuchi, M. (1995) · Biochemistry · doi:10.1021/bi00012a012 · Cited by 124

Analysis of the α4β1 Integrin–Osteopontin Interaction

Barry, S. T., Ludbrook, S. B., Murrison, E., & Horgan, C. M. T. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4941 · Cited by 123

Parathyroid Hormone-induced Bone Resorption Does Not Occur in the Absence of Osteopontin

Ihara, H., Denhardt, D. T., Furuya, K., Yamashita, T., Muguruma, Y., Tsuji, K., Hruska, K. A., Higashio, K., ENOMOTO, S., Nifuji, A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010938200 · Cited by 125

Osteopontin and the Bone Remodeling Sequence

McKee, M. D., & Nanci, A. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44629.x · Cited by 121

Integrins αvβ3and α5β1Mediate Attachment of Lyme Disease Spirochetes to Human Cells

Coburn, J., Magoun, L., Bodary, S. C., & Leong, J. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1946-1952.1998 · Cited by 121

Evidence for the formation of a complex between osteopontin and osteocalcin

Ritter, N. M., Farach‐Carson, M. C., & Butler, W. T. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070804 · Cited by 120

Tumor-Selective Response to Antibody-Mediated Targeting of αvβ3 Integrin in Ovarian Cancer

Landen, C. N., Kim, T.-J., Lin, Y. G., Merritt, W. M., Kamat, A. A., Han, L. Y., Spannuth, W. A., Nick, A. M., Jennnings, N. B., Kinch, M. S., et al. (2008) · Neoplasia · doi:10.1593/neo.08740 · Cited by 120

Bone sialoprotein expression in primary human breast cancer is associated with bone metastases development

Bellahcène, A., Kroll, M., Liebens, F., & Castronovo, V. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110514 · Cited by 120

Molecular and cellular biology of osteopontin

Giachelli, C. M., Schwartz, S. M., & Liaw, L. (1995) · Trends in Cardiovascular Medicine · doi:10.1016/1050-1738(95)00005-t · Cited by 119

Osteopontin is a negative regulator of proliferation and differentiation in MC3T3-E1 pre-osteoblastic cells

Huang, W., Carlsen, B. T., Rudkin, G. H., Berry, M. D., Ishida, K., Yamaguchi, D. T., & Miller, T. A. (2004) · Bone · doi:10.1016/j.bone.2003.11.027 · Cited by 118

Activation of Integrin αVβ3 Regulates Cell Adhesion and Migration to Bone Sialoprotein

Byzova, T. V., Kim, W., Midura, R. J., & Plow, E. F. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4765 · Cited by 114

The Role of αv Integrins during Angiogenesis

Eliceiri, B. P., & Cheresh, D. A. (1998) · Molecular Medicine · doi:10.1007/bf03401768 · Cited by 118

Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis.

Diel, I., Solomayer, E., Seibel, M. J., Pfeilschifter, J., Maisenbacher, H. W., Gollan, C., Pecherstorfer, M., Conradi, R., Kehr, G., Boehm, E., et al. (1999) · PubMed · Cited by 117

Tumor-specific cell surface expression of the -KDEL containing endoplasmic reticular heat shock protein gp96

Altmeyer, A., Maki, R. G., Feldweg, A. M., Heike, M., Protopopov, V., Masur, S. K., & Srivastava, P. K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960822)69:4 · Cited by 174

c-myc-dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors

Xu, Y., Nguyen, Q., Lo, D. C., & Czaja, M. J. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199702)170:2 · Cited by 70

Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β

Rickard, D. J., Monroe, D. G., Ruesink, T., Khosla, S., Riggs, B. L., & Spelsberg, T. C. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10539 · Cited by 115

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

Lowell, C., Niwa, M., Soriano, P. M., & Varmus, H. E. (1996) · Blood · doi:10.1182/blood.v87.5.1780.1780 · Cited by 115

Bone Health in Patients with Dyslipidemias: An Underestimated Aspect

Anagnostis, P. G., Florentin, M., Livadas, S., Lambrinoudaki, I. V., & Goulis, D. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031639 · Cited by 114

New Insight in Eggshell Formation

Lavelin, I., Meiri, N., & Pines, M. (2000) · Poultry Science · doi:10.1093/ps/79.7.1014 · Cited by 113

Osteoclasts, integrins, and osteoporosis

Teitelbaum, S. L. (2000) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740070007 · Cited by 113

Ovine Osteopontin: I. Cloning and Expression of Messenger Ribonucleic Acid in the Uterus During the Periimplantation Period1

Johnson, G. A., Spencer, T. E., Burghardt, R. C., & Bazer, F. W. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.4.884 · Cited by 113

3D Molecularly Functionalized Cell‐Free Biomimetic Scaffolds for Osteochondral Regeneration

Li, L., Li, J., Guo, J., Zhang, H., Zhang, X., Yin, C., Wang, L., Zhu, Y., & Yao, Q. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201807356 · Cited by 111

Collageneous matrix coatings on titanium implants modified with decorin and chondroitin sulfate: Characterization and influence on osteoblastic cells

Bierbaum, S., Douglas, T., Hanke, T., Scharnweber, D., Tippelt, S., Monsees, T. K., Funk, R. H. W., & Worch, H. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30572 · Cited by 109

Meltrin-α, a Fusion Protein Involved in Multinucleated Giant Cell and Osteoclast Formation

Abe, E., Mocharla, H., Yamate, T., Taguchi, Y., & Manolagas, S. C. (1999) · Calcified Tissue International · doi:10.1007/s002239900641 · Cited by 110

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.

Carron, C., Meyer, D. M., Pegg, J. A., Engleman, V. W., Nickols, M. A., Settle, S. L., Westlin, W., Ruminski, P. G., & Nickols, G. A. (1998) · PubMed · Cited by 108

Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption

Peng, H., Troen, T., Ovejero, M. D. C., Kirkegaard, T., Andersen, T. L., Byrjalsen, I., Ferreras, M., Sato, T., Shapiro, S. D., Foged, N. T., et al. (2003) · Bone · doi:10.1016/j.bone.2003.08.011 · Cited by 107

Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma

Carlinfante, G., Vassiliou, D., Svensson, O., Wendel, M., Heinegård, D. K., & Andersson, G. (2003) · Clinical & Experimental Metastasis · doi:10.1023/a:1025419708343 · Cited by 106

Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions

Xuan, J., Hota, C., Shigeyama, Y., D'Errico, J. A., Somerman, M. J., & Chambers, A. F. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240570413 · Cited by 106

Bone Mineralization and Osteoblast Differentiation Are Negatively Modulated by Integrin αvβ3

Cheng, S., Lai, C.-F., Blystone, S. D., & Avioli, L. V. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.277 · Cited by 105

Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion

Razzouk, S., Brunn, J. C., Qin, C., Tye, C. E., Goldberg, H. A., & Butler, W. T. (2002) · Bone · doi:10.1016/s8756-3282(01)00637-8 · Cited by 105

Steroid Regulation of Cell Specific Secreted Phosphoprotein 1 (Osteopontin) Expression in the Pregnant Porcine Uterus1

White, F. J., Ross, J. W., Joyce, M. M., Geisert, R. D., Burghardt, R. C., & Johnson, G. A. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.045153 · Cited by 104

Osteoclast Signal Transduction During Bone Metastasis Formation

Győri, D., & Mócsai, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00507 · Cited by 107

Structural elements of the osteopontin SVVYGLR motif important for the interaction with α4 integrins

Green, P. M., Ludbrook, S. B., Miller, D. D., Horgan, C. M. T., & Barry, S. T. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02690-4 · Cited by 101

Alpha-v Integrins as Therapeutic Targets in Oncology

Nemeth, J. A., Nakada, M. T., Trikha, M., Lang, Z., Gordon, M. S., Jayson, G. C., Corringham, R. E., Prabhakar, U., Davis, H. M., & Beckman, R. A. (2007) · Cancer Investigation · doi:10.1080/07357900701522638 · Cited by 100

The Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mediates Actions of Both Ligands in Murine Bone**This work was supported by National Institute of Health Grants DK-47038 and AM-03564.

Lanske, B., Pajevic, P. D., Kovács, C. S., Pirro, A. E., Landis, W. J., Krane, S. M., Bringhurst, F. R., & Kronenberg, H. M. (1998) · Endocrinology · doi:10.1210/endo.139.12.6361 · Cited by 100

Serum immunoreactive bone sialoprotein as a new marker of bone turnover in metabolic and malignant bone disease

Seibel, M. J., Woitge, H. W., Pecherstorfer, M., Karmatschek, M., Horn, E. M., Ludwig, H., Armbruster, F. P., & Ziegler, R. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784085 · Cited by 100

Collagen-binding I domain integrins — what do they do?

Gullberg, D., & Evy Lundgren-akerlund, B. (2002) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(02)80008-0 · Cited by 98

Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: Role of cAMP-dependent protein kinase

Kaji, H., Sugimoto, T., Kanatani, M., Fukase, M., Kumegawa, M., & Chihara, K. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110110 · Cited by 97

Osteoblasts induce osteopontin expression in response to attachment on fibronectin: Demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation

Carvalho, R. S., Schaffer, J. L., & Gerstenfeld, L. C. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980901)70:3 · Cited by 97

Structural Characterization of Human Recombinant and Bone-derived Bone Sialoprotein

Wuttke, M., Müller, S., Nitsche, D. P., Paulsson, M., Hanisch, F., & Maurer, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105689200 · Cited by 96

Osteopontin expression in mammary gland development and tumorigenesis.

Rittling, S. R., & Novick, K. E. (1997) · PubMed · Cited by 96

Coupling of Osteopontin and Its Cell Surface Receptor CD44 to the Cell Survival Response Elicited by Interleukin-3 or Granulocyte-Macrophage Colony-Stimulating Factor

Lin, Y.-H., Huang, C., Chao, J.-R., Chen, S., Lee, S.-F., Yen, J. J.-Y., & Yang‐Yen, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2734-2742.2000 · Cited by 95

Osteoblast-like Cells Complete Osteoclastic Bone Resorption and Form New Mineralized Bone Matrix In Vitro

Mulari, M. T. K., Qu, Q., H�rk�nen, P. L., & V��n�nen, H. K. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0172-3 · Cited by 93

Role of Two Mineral-Associated Adhesion Molecules, Osteopontin and Bone Sialoprotein, during Cementogenesis

MacNeil, R. L., Berry, J., D'Errico, J. A., Strayhorn, C. L., Piotrowski, B. T., & Somerman, M. J. (1995) · Connective Tissue Research · doi:10.3109/03008209509016974 · Cited by 92

Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy

Yamate, T., Mocharla, H., Taguchi, Y., Igietseme, J. U., Manolagas, S. C., & Abe, E. (1997) · Endocrinology · doi:10.1210/en.138.7.3047 · Cited by 91

Novel Functions of the Matricellular Proteins Osteopontin and Osteonectin/SPARC

Sodek, J., Zhu, B., Huynh, M., Brown, T. J., & Ringuette, M. J. (2002) · Connective Tissue Research · doi:10.1080/03008200290001050 · Cited by 90

The underlying pathophysiology and therapeutic approaches for osteoporosis

Awasthi, H., Mani, D., Singh, D. R., & Gupta, A. K. (2018) · Medicinal Research Reviews · doi:10.1002/med.21504 · Cited by 90

Phase II study of Cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium

Alva, A. S., Slovin, S. F., Daignault, S. D., Carducci, M. A., DiPaola, R. S., Pienta, K. J., Agus, D. B., Cooney, K. A., Chen, A. P., Smith, D. C., et al. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9573-5 · Cited by 88

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

Sheldrake, H. M., & Patterson, L. H. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5000547 · Cited by 88

Glucocorticoids inhibit the attachment of osteoblasts to bone extracellular matrix proteins and decrease beta 1-integrin levels.

Gronowicz, G. A., & McCarthy, M. B. (1995) · Endocrinology · doi:10.1210/endo.136.2.7530648 · Cited by 87

Osteopontin Expression in Uterine Stroma Indicates a Decidualization-Like Differentiation During Ovine Pregnancy

Johnson, G. A., Burghardt, R. C., Joyce, M. M., Spencer, T. E., Bazer, F. W., Pfarrer, C. D., & Gray, C. A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.012948 · Cited by 87

Isolation and Biological Properties of Osteopontin from Bovine Milk

Bayless, K. J., Davis, G. E., & Meininger, G. A. (1997) · Protein Expression and Purification · doi:10.1006/prep.1996.0699 · Cited by 85

Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat

Crippes, B. A., Engleman, V. W., Settle, S. L., Delarco, J., Ornberg, R., Helfrich, M., Horton, M. A., & Nickols, G. A. (1996) · Endocrinology · doi:10.1210/endo.137.3.8603604 · Cited by 85

An Allosteric Ca2+ Binding Site on the β3-Integrins That Regulates the Dissociation Rate for RGD Ligands

Hu, D. D., Barbas, C. F., & Smith, J. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21745 · Cited by 85

Attachment of osteoblastic cells to hydroxyapatite crystals by a synthetic peptide (Glu7-Pro-Arg-Gly-Asp-Thr) containing two functional sequences of bone sialoprotein

Fujisawa, R., Mizuno, M., Nodasaka, Y., & Kuboki, Y. (1997) · Matrix Biology · doi:10.1016/s0945-053x(97)90113-x · Cited by 84

IL-1 Up-Regulates Osteopontin Expression in Experimental Crescentic Glomerulonephritis in the Rat

Yu, X., Fan, J.-M., Nikolic‐Paterson, D. J., Yang, N., Mu, W., Pichler, R. H., Johnson, R. J., Atkins, R. C., & Lan, H. Y. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65330-8 · Cited by 84

Further characterization of interaction between bone sialoprotein (BSP) and collagen

Fujisawa, R., Nodasaka, Y., & Kuboki, Y. (1995) · Calcified Tissue International · doi:10.1007/bf00296346 · Cited by 83

Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.

Standal, T., Hjorth‐Hansen, H., Rasmussen, T., Dahl, I. M. S., Lenhoff, S., Brenne, A., Seidel, C., Baykov, V., Waage, A., Børset, M., et al. (2004) · PubMed · Cited by 83

Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes

Chiarelli, N., Ritelli, M., Zoppi, N., & Colombi, M. (2019) · Genes · doi:10.3390/genes10080609 · Cited by 82

Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes

Ueno, H., Murakami, M., Okumura, M., KADOSAWA, T., Uede, T., & FUJINAGA, T. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00328-8 · Cited by 82

TGFβ and BMP-2 Activation of the OPN Promoter: Roles of Smad- and Hox-Binding Elements

Hullinger, T. G., Pan, Q., Viswanathan, H. L., & Somerman, M. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5074 · Cited by 82

Application of RGD-containing peptides as imaging probes for alphavbeta3 expression

Dijkgraaf, I. (2009) · Frontiers in bioscience · doi:10.2741/3284 · Cited by 81

Inhibition of Arg-Gly-Asp (RGD)-mediated cell adhesion to osteopontin by a monoclonal antibody against osteopontin.

Bautista, D., Xuan, J. W., Hota, C., Chambers, A. F., & Harris, J. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31650-2 · Cited by 81

A Regulated Interaction between α5β1 Integrin and Osteopontin

Barry, S. T., Ludbrook, S. B., Murrison, E., & Horgan, C. M. T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2032 · Cited by 80

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis

Houben, A., Kostanova‐Poliakova, D., Weißenböck, M., Graf, J., Teufel, S., von der Mark, K., & Hartmann, C. (2016) · Development · doi:10.1242/dev.137489 · Cited by 83

Controlled release of simvastatin‐loaded thermo‐sensitive PLGA‐PEG‐PLGA hydrogel for bone tissue regeneration: in vitro and in vivo characteristics

Yan, Q., Xiao, L., Tan, L., Sun, W. Y., Wu, T., Chen, L., Mei, Y., & Shi, B. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35499 · Cited by 79

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen, M., Terhal, P. A., Botto, L. D., Henning, P., Mäkitie, R. E., Roschger, P., Jain, A., Kol, M. A., Kjellberg, M. A., Paschalis, E. P., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126180 · Cited by 79

Expression of Bone Sialoprotein in Human Lung Cancer

Bellahcène, A., Maloujahmoum, N., Fisher, L. W., Pastorino, H., Tagliabue, E., Ménard, S., & CASTRONOVO, V. (1997) · Calcified Tissue International · doi:10.1007/s002239900320 · Cited by 77

Molecular mechanisms of bone resorption

Teitelbaum, S. L., Abu‐Amer, Y., & Ross, F. P. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590102 · Cited by 77

PU.1 and NFATc1 mediate osteoclastic induction of the mouse β3 integrin promoter

Crotti, T. N., Sharma, S. M., Fleming, J. D., Flannery, M. R., Ostrowski, M. C., Goldring, S. R., & McHugh, K. P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21344 · Cited by 76

BSP and RANKL Induce Osteoclastogenesis and Bone Resorption Synergistically

Valverde, P., Tu, Q., & Chen, J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050511 · Cited by 76

Chronic metabolic acidosis reversibly inhibits extracellular matrix gene expression in mouse osteoblasts

Frick, K. K., & Bushinsky, D. A. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.275.5.f840 · Cited by 76

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.

Médico, E., Gentile, A., Celso, C. L., Williams, T. A., Gambarotta, G., Trusolino, L., & Comoglio, P. M. (2001) · PubMed · Cited by 75

Inhibition of αvβ3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases

Nemeth, J. A., Cher, M. L., Zhao, Z., Mullins, C. M., Bhagat, S., & Trikha, M. (2003) · Clinical & Experimental Metastasis · doi:10.1023/a:1025461507027 · Cited by 74

Cellular and Molecular Pathology of Prostate Cancer Precursors

Foster, C. S., Bostwick, D. G., Bonkhoff, H., Damber, J., van der Kwast, T., Montironi, R., & Sakr, W. A. (2000) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655900750169284 · Cited by 74

The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification

Demer, L. L., & Tintut, Y. (2011) · Circulation Research · doi:10.1161/circresaha.110.234245 · Cited by 76

Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis.

Rehman, Q., & Lane, N. E. (2001) · Arthritis Research · doi:10.1186/ar305 · Cited by 73

Biochemical Characterization of the Binding of Echistatin to Integrin αvβ3 Receptor

Kumar, C. C., Nie, H., Rogers, C. P., Malkowski, M., Maxwell, E., Catino, J. J., & Armstrong, L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37071-5 · Cited by 73

Transcription of the bone sialoprotein gene is stimulated by v-Src acting through an inverted CCAAT box.

Kim, R. H., & Sodek, J. (1999) · PubMed · Cited by 72

A Genome-Wide Association Study Identifies Multiple Regions Associated with Head Size in Catfish

Geng, X., Liu, S., Yao, J., Bao, L., Zhang, J., Li, C., Wang, R., Sha, J., Zeng, P., Zhi, D., et al. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.032201 · Cited by 71

Antioxidative peptide from milk exhibits antiosteopenic effects through inhibition of oxidative damage and bone-resorbing cytokines in ovariectomized rats

Mada, S. B., Reddi, S., Kumar, N., Kumar, R., Kapila, S., Kapila, R., Trivedi, R., Karvande, A., & Ahmad, N. (2017) · Nutrition · doi:10.1016/j.nut.2017.06.010 · Cited by 71

Alteration of proteoglycan synthesis in human lung fibroblasts induced by interleukin-1? and tumor necrosis factor-?

Tufvesson, E., & Westergren‐Thorsson, G. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000501)77:2 · Cited by 65

Towards a better understanding and new therapeutics of osteopetrosis

Askmyr, M., Fasth, A. L., & Richter, J. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.06983.x · Cited by 71

Cytokine regulation during the formation of the fetal–maternal interface: Focus on cell–cell adhesion and remodelling of the extra-cellular matrix

McEwan, M. V., Lins, R. J., Munro, S. K., Vincent, Z. L., Ponnampalam, A. P., & Mitchell, M. D. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.05.004 · Cited by 69

Dissection of platelet and myeloid cell defects by conditional targeting of the β3‐integrin subunit

Morgan, E. A., Schneider, J. G., Baroni, T. E., Uluçkan, Ö., Heller, E., Hurchla, M. A., Deng, H., Floyd, D. H., Berdy, A., Prior, J. L., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-138420 · Cited by 68

Plasminogen Activator Inhibitor–1 Impairs Alveolar Epithelial Repair by Binding to Vitronectin

Lazar, M. H., Christensen, P. J., Du, M., Yu, B., Subbotina, N. M., Hanson, K. E., Hansen, J. M., White, E. S., Simon, R. H., & Sisson, T. H. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0025oc · Cited by 67

Effects of Different Titanium Alloys and Nanosize Surface Patterning on Adhesion, Differentiation, and Orientation of Osteoblast-Like Cells

Monsees, T. K., Barth, K., Tippelt, S., Heidel, K., Gorbunov, A., Pompe, W., & Funk, R. H. W. (2005) · Cells Tissues Organs · doi:10.1159/000086749 · Cited by 67

Glomerular osteopontin expression and macrophage infiltration in glomerulosclerosis of DOCA–salt rats

Hartner, A., Porst, M., Gauer, S., Pröls, F., Veelken, R. A., & Hilgers, K. F. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.25209 · Cited by 67

Overexpression of Bone Sialoprotein Leads to an Uncoupling of Bone Formation and Bone Resorption in Mice

Valverde, P., Zhang, J., Fix, A., Zhu, J., Ma, W., Tu, Q., & Chen, J. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080605 · Cited by 65

Runx2- and Histone Deacetylase 3-mediated Repression Is Relieved in Differentiating Human Osteoblast Cells to Allow High Bone Sialoprotein Expression

Lamour, V., Detry, C., Sanchez, C., Henrotin, Y. E., Castronovo, V., & Bellahcène, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705833200 · Cited by 65

Phospholipase Cγ2 Modulates Integrin Signaling in the Osteoclast by Affecting the Localization and Activation of Src Kinase

Epple, H., Cremasco, V., Zhang, K., Mao, D., Longmore, G. D., & Faccio, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00259-08 · Cited by 64

Osteopontin deficiency and aging on nanomechanics of mouse bone

Kavukcuoglu, N. B., Denhardt, D. T., Güzelsu, N., & Mann, A. B. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31081 · Cited by 64

Expression and presence of osteopontin and integrins in the bovine oviduct during the oestrous cycle

Gabler, C., Chapman, D. A., & Killian, G. J. (2003) · Reproduction · doi:10.1530/rep.0.1260721 · Cited by 63

Osteopontin Expression Is Increased in the Heritable Cardiomyopathy of Syrian Hamsters

Williams, E. B., Halpert, I., Wickline, S. A., Davison, G. E., Parks, W. C., & Rottman, J. N. (1995) · Circulation · doi:10.1161/01.cir.92.4.705 · Cited by 63

Cellular distribution and regulation of NHE-1 isoform of the Na-H exchanger in the avian osteoclast

Gupta, A., Edwards, J., & Hruska, K. A. (1996) · Bone · doi:10.1016/8756-3282(95)00455-6 · Cited by 62

A novel protein kinase C α-dependent signal to ERK1/2 activated by αVβ3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells

Rucci, N., Di Giacinto, C., Orrù, L., Millimaggi, D., Baron, R., & Teti, A. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02436 · Cited by 63

Interaction of Osteopontin with Osteoclast Integrinsa

Horton, M. A., Nesbit, M. A., & Helfrich, M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44630.x · Cited by 53

Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone

Carron, C. P., Meyer, D. M., Engleman, V. W., RICO, J. G., Ruminski, P. G., Ornberg, R., Westlin, W., & Nickols, G. A. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650587 · Cited by 52

β1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption

Helfrich, M. H., Nesbitt, S. A., Lakkakorpi, P. T., Barnes, M. J., Bodary, S. C., Shankar, G., Mason, W. T., Mendrick, D. L., Väänänen, H. K., & Horton, M. A. (1996) · Bone · doi:10.1016/s8756-3282(96)00223-2 · Cited by 139

Involvement of αvβ3 integrins in osteoclast function

Nakamura, I., Duong, L. T., Rodan, S. B., & Rodan, G. A. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0773-9 · Cited by 224

Integrin function in osteoclasts

Rodan, S. B., & Rodan, G. A. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.154s047 · Cited by 111