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Cited by 540Bone and Dental Protein StudiesBone Metabolism and DiseasesCell Adhesion Molecules Research

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

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Ross, F.P., Chappel, J., Alvarez, J.I., Sander, D., Butler, W.T., Farach-Carson, M.C., Mintz, K.A., Robey, P.G., Teitelbaum, S.L., Cheresh, D.A.·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)98430-9
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Abstract

We have investigated the mechanism by which osteoclasts adhere to and resorb bone. We show that these cells express beta 1 and beta 3 integrins which are involved in attachment to purified bone matrix proteins. Binding to osteopontin and bone sialoprotein is mediated by alpha v beta 3, while a beta 1 integrin is responsible for attachment to fibronectin. Both the rapid attachment by osteoclasts to intact bone particles and their subsequent resorption are blocked by a monoclonal antibody directed to the alpha v beta 3 complex but not by an antibody against beta 1 integrins. Attachment of osteoclasts to bone is also inhibited with soluble osteopontin, Arg-Gly-Asp-containing peptides derived from both osteopontin and bone sialoprotein, or a monospecific polyclonal antibody against osteopontin. We conclude that both osteoclast adherence to bone and subsequent resorption of its matrix are dependent on interactions between the bone matrix proteins osteopontin and/or bone sialoprotein and the integrin alpha v beta 3. Moreover, collagen, which constitutes 90% of its organic matrix, is minimally involved in binding of chicken osteoclasts to bone.

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Crossref · 10.1016/s0021-9258(18)98430-9

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Research works printed but not linked: 2

  1. Chambers, 1986, Bone Miner., 1, 127
  2. Goldman, 1979, Natl. Cancer Inst., 63, 1009

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Metadata

Authors
Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A.
Affiliations
  • National Institutes of Health (US)
  • Scripps Research Institute (US)
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-05
Volume
268
Issue
13
Pages
9901-9907
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)98430-9
OpenAlex
W1511542029
Cited by
537
References
56
Citations by year
2026: 6 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 11
FWCI
28.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ar039273-12)
  • National Cancer Institute (CA-50286, CA-47526)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR39273)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
osteoclasts, osteopontin, bone sialoprotein, alpha v beta 3 integrin, beta1 integrin, bone resorption, bone matrix proteins, fibronectin, RGD peptide, collagen
MeSH terms
Amino Acid Sequence, Animals, Bone Matrix, Bone Resorption, Cell Adhesion, Humans, Kinetics, Models, Biological, Molecular Sequence Data, Oligopeptides, Osteoclasts, Sialoglycoproteins, Integrins, Rats, Osteopontin, Integrin-Binding Sialoprotein

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