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Cited by 277

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

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Fasolato, C, Hoth, M, Penner, R·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)36843-7
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Abstract

Calcium influx in electrically non-excitable cells is regulated by the filling state of intracellular calcium stores. Depletion of stores activates plasma membrane channels that are voltage-independent and highly selective for Ca2+ ions. We report here that the activation of plasma membrane Ca2+ currents induced by depletion of Ca2+ stores requires a diffusible cytosolic factor that washes out with time when dialyzing cells in the whole-cell configuration of the patch-clamp technique. The activation of calcium release-activated calcium current (ICRAC) by ionomycin- or inositol 1,4,5-trisphosphate-induced store depletion is blocked by guanosine 5'-3-O-(thio)triphosphate (GTP gamma S) and guanyl-5'-yl imidodiphosphate, non-hydrolyzable analogs of GTP, suggesting the involvement of a GTP-binding protein. The inhibition by GTP gamma S occurs at a step prior to the activation of ICRAC and is prevented by the addition of GTP. We conclude that the activation mechanism of depletion-induced Ca2+ influx encompasses a GTP-dependent step, possibly involving an as yet unidentified small GTP-binding protein.

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Metadata

Authors
Fasolato, C., Hoth, M., & Penner, R.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-10
Volume
268
Issue
28
Pages
20737-20740
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)36843-7
OpenAlex
W1857056367
Cited by
277
References
18
FWCI
14.31
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: A GTP-dependent step in the activation mechanism of capacitative calcium influx. https://app.cochat.ai/papers/10.1016/s0021-9258(19)36843-7
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Fasolato, C., Hoth, M., & Penner, R. (1993). A GTP-dependent step in the activation mechanism of capacitative calcium influx. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)36843-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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