The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
In Vitro and in Vivo Formation of Two New Metabolites of Melatonin
Open accessAbstract
A partially purified enzyme from rabbit brain catalyzed the oxygenative cleavage of the pyrrole moiety of melatonin yielding Nr-acetyl-NZ-formyl-5-methoxykynurenamine, which was further degraded to NY-acetyl-5-methoxykynurenamine by the action of formamidase.Authentic samples of these two metabolites were synthesized by ozonolysis of melatonin and were shown to be indistinguishable from the enzymic products.When [14C]melatonin was injected intracisternally, the major metabolite in the rat brain was shown to be NY-acetyl-S-methoxykynurenamine.The results indicate that these two new metabolites are involved in the major metabolic pathway of melatonin in the central nervous system.
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Cites
DIFFERENTIAL SPECTROPHOTOMETRY OF PURINE COMPOUNDS BY MEANS OF SPECIFIC ENZYMES
Kalckar, H. M. (1947) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30999-7 · Cited by 1,118
Purification and Properties of Hydroxyindole-O-methyl Transferase
Axelrod, J., & Weissbach, H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64458-8 · Cited by 410
The Fate of Melatonin in Animals
Kopin, I. J., Pare, C. M. B., Axelrod, J., & Weissbach, H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76431-x · Cited by 338
Tryptophan Pyrrolase of Rabbit Intestine
Yamamoto, S., & Hayaishi, O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99420-2 · Cited by 289
Self-citationBiosynthesis of melatonin: enzymic conversion of serotonin to N-acetylserotonin
Weissbach, H., Redfield, B. G., & Axelrod, J. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90453-4 · Cited by 262
Enzymic formation of D-kynurenine from D-tryptophan.
Higuchi, K., & Hayaishi, O. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90256-1 · Cited by 105
Self-citationHirata, F., & Hayaishi, O. (1972) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/0006-291x(72)90949-7 · Cited by 87
Self-citationPossible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction.
Hirata, F., & Hayaishi, O. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45852-3 · Cited by 81
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Cited by
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601
Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins
Huang, X., & Groves, J. T. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00373 · Cited by 1,037
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Melatonin membrane receptors in peripheral tissues: Distribution and functions
Slominski, R. M., Reiter, R. J., Schlabritz-Loutsevitch, N., Ostrom, R. S., & Slominski, A. T. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.004 · Cited by 675
Metadata
- Authors
- Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1974-02
- Volume
- 249
- Issue
- 4
- Pages
- 1311-1313
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2157835171
- Cited by
- 323
- References
- 8
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S. (1974). In Vitro and in Vivo Formation of Two New Metabolites of Melatonin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)42976-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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