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Cited by 291

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Characterization of the Interaction of a Protein Inhibitor with Adenosine 3′,5′-Monophosphate-dependent Protein Kinases

Open access
Ashby, C. Dennis, Walsh, Donal A.·1972·Journal of Biological Chemistry

Abstract

The interaction of a protein inhibitor with the catalytic subunit derived from adenosine 3′,5′-monophosphate-dependent protein kinase is described. A kinetic analysis of casein phosphorylation in the presence of inhibitor reveals a noncompetitive interaction between the inhibitor and the catalytic subunit substrates, ATP and casein. The inhibitor does not function by destroying ATP nor by acting as a phosphoprotein phosphatase. The inhibitor is equally effective when protein kinase is assayed with various protein substrates. Catalytic subunit activity is inhibited to the same plateau level by the inhibitor and by regulatory subunit derived from adenosine 3′,5′-monophosphate-dependent protein kinase. The inhibitor interaction with the catalytic subunit prevents the catalytic subunit-induced release of adenosine 3′,5′-monophosphate from the regulatory subunit.

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Metadata

Authors
Ashby, C. D., & Walsh, D. A.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1972-10
Volume
247
Issue
20
Pages
6637-6642
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1567714394
Cited by
291
References
10
FWCI
6.25
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Characterization of the Interaction of a Protein Inhibitor with Adenosine 3′,5′-Monophosphate-dependent Protein Kinases. https://app.cochat.ai/papers/10.1016/s0021-9258(19)44739-x
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Ashby, C. D., & Walsh, D. A. (1972). Characterization of the Interaction of a Protein Inhibitor with Adenosine 3′,5′-Monophosphate-dependent Protein Kinases. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)44739-x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.