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Cited by 160

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Isolation of the Luteinizing Hormone and Follicle-stimulating Hormone-releasing Hormone from Porcine Hypothalami

Open access
Schally, Andrew V., Nair, R.M.G., Redding, Tommie W., Arimura, Akira·1971·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)45877-8
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Abstract

Abstract A new procedure is described for the isolation on a preparative scale of a hypothalamic decapeptide which stimulates the release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. The isolation was achieved mainly by countercurrent distribution. The yield from 240,000 porcine hypothalami was 11.4 mg. Thin layer chromatography and electrophoresis showed the material to be homogeneous. The amino acid analyses showed the presence of 2 residues of glycine and 1 residue each of histidine, arginine, tryptophan, serine, glutamic acid, proline, leucine, and tyrosine. This decapeptide stimulates release of both LH and FSH in vivo as well as in vitro in doses smaller than 1 ng. It is thought to be the hypothalamic hormone which controls secretion of both LH and FSH from the pituitary gland.

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Research works printed but not linked: 32

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Cited by

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Metadata

Authors
Schally, A. V., Nair, R. M. G., Redding, T. W., & Arimura, A.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1971-12
Volume
246
Issue
23
Pages
7230-7236
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)45877-8
OpenAlex
W1554882129
Cited by
160
References
0
FWCI
14.69
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Isolation of the Luteinizing Hormone and Follicle-stimulating Hormone-releasing Hormone from Porcine Hypothalami. https://app.cochat.ai/papers/10.1016/s0021-9258(19)45877-8
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Schally, A. V., Nair, R. M. G., Redding, T. W., & Arimura, A. (1971). Isolation of the Luteinizing Hormone and Follicle-stimulating Hormone-releasing Hormone from Porcine Hypothalami. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)45877-8

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