The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Somatostatinoma Syndrome: Biochemical, Morphologic and Clinical Features
Abstract
Diabetes mellitus, steatorrhea, cholelithiasis and a tumor distorting the duodenum prompted a work-up for somatostatinoma in a 52-year-old man. The responses of pancreatic B-cells but not of A-cells to nutrient stimuli were inhibited, and growth-hormone release was suppressed, suggesting somatostatin resistance in some target tissues. Plasma somatostatin-like immunoreactivity ranged from 9000 to 13,000 pg per milliliter (normal: 88+/-8, mean +/- S.E.M.) and was distributed in four molecular forms, including free somatostatin. The primary tumor contained 5 microgram of somatostatin-like immunoreactivity per milligram of wet tissue, distributed in three of the molecular forms noted in plasma. Plasma calcitonin was also elevated (4650 pg per milliliter; normal: less than 120). Immunocytochemical studies showed that cells of the primary tumor contained somatostatin and calcitonin but no other peptide hormones. Only somatostatin was present in the metastases. Somatostatin was localized electron microscopically in all secretory granules, irrespective of size and shape, whereas calcitonin was present only within a single subpopulation of small granules in the same cells.
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Cites
STUDIES ON ANTIBODY PRODUCTION
Coons, A. H., Leduc, E. H., & Connolly, J. M. (1955) · The Journal of Experimental Medicine · doi:10.1084/jem.102.1.49 · Cited by 1,555
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex.
Roth, J., Bendayan, M., & Orci, L. (1978) · Journal of Histochemistry & Cytochemistry · doi:10.1177/26.12.366014 · Cited by 980
Self-citationStudies of pancreatic alpha cell function in normal and diabetic subjects
Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837
Self-citationLarsson, L.-I., Holst, J. J., Kühl, C., Lundqvist, G., Hirsch, M. A., Ingemansson, S., Lindkaer Jensen, S., Rehfeld, J. F., & Schwartz, T. W. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92113-4 · Cited by 318
“Somatostatinoma”: A Somatostatin-Containing Tumor of the Endocrine Pancreas
Ganda, O. P., Weir, G. C., Soeldner, J. S., Legg, M. A., Chick, W. L., Patel, Y. C., Ebeid, A. M., Gabbay, K. H., & Reichlin, S. (1977) · New England Journal of Medicine · doi:10.1056/nejm197704282961703 · Cited by 290
GERICH, J. E., LOVINGER, R., & GRODSKY, G. M. (1975) · Endocrinology · doi:10.1210/endo-96-3-749 · Cited by 164
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Self-citationSchally, A. V., Nair, R. M. G., Redding, T. W., & Arimura, A. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45877-8 · Cited by 160
Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.
McIntosh, C. H. S., Arnold, R., Bothe, E., Becker, H. D., Köbberling, J., & Creutzfeldt, W. (1978) · Gut · doi:10.1136/gut.19.7.655 · Cited by 133
INHIBITION OF CHOLECYSTOKININ-PANCREOZYMIN RELEASE BY SOMATOSTATIN
Schlegel, W. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90182-9 · Cited by 99
Cited by
Gastrointestinal Neuroendocrine Tumors: Pancreatic Endocrine Tumors
Metz, D. C., & Jensen, R. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.047 · Cited by 816
Human somatostatin I: sequence of the cDNA.
Shen, L. P., Pictet, R. L., & Rutter, W. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.15.4575 · Cited by 279
Gerich, J. E. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90584-2 · Cited by 50
WITHDRAWN: Reprint of: Classification of diabetes mellitus
Adler, A., Bennett, P., Chair, S. C., Gregg, E., Venkat Narayan, K. M., Schmidt, M. I., Sobngwi, E., Tajima, N., Tandon, N., Unwin, N., et al. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108972 · Cited by 38
Retracted
Metadata
- Authors
- Krejs, G. J., Orci, L., Conlon, J. M., Ravazzola, M., Davis, G. R., Raskin, P., Collins, S. M., McCarthy, D. M., Baetens, D., Rubenstein, A., Aldor, T. A. M., & Unger, R. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-08-09
- Volume
- 301
- Issue
- 6
- Pages
- 285-292
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1989883614
- Cited by
- 395
- References
- 18
- FWCI
- 23.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Somatostatinoma Syndrome: Biochemical, Morphologic and Clinical Features. https://app.cochat.ai/papers/10.1056/nejm197908093010601
- The paper
- Krejs, G. J., Orci, L., Conlon, J. M., Ravazzola, M., Davis, G. R., Raskin, P., Collins, S. M., McCarthy, D. M., Baetens, D., Rubenstein, A., Aldor, T. A. M., & Unger, R. H. (1979). Somatostatinoma Syndrome: Biochemical, Morphologic and Clinical Features. New England Journal of Medicine. https://doi.org/10.1056/nejm197908093010601
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
