The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.
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“the continual hydrolysis and re-esterification of droplet cholesterol constitutes a futile cycle that wastes ATP and thereby contributes to the premature death of the foam cells in poorly oxygenated regions of atherosclerotic lesions24,25.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [24]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
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Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Lipid extraction of tissues with a low-toxicity solvent
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Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447
Self-citationThe Metabolic Basis of Inherited Disease
Solomon, L. M. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12541649 · Cited by 2,074
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906
In vitro methods in cell-mediated and tumor immunity
Bloom, B. R., & David, J. R. (1976) · Academic Press eBooks · Cited by 1,273
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins.
Brown, M. S., Goldstein, J. L., Krieger, M., Ho, Y. K., & Anderson, R. G. W. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.82.3.597 · Cited by 551
Self-citationRegulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts
Brown, M. S., Dana, S. E., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42998-0 · Cited by 545
Self-citationGoldstein, J. L., Ho, Y. K., Brown, M. S., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85958-6 · Cited by 376
Self-citation
Research works printed but not linked: 5
- Mahley, 1979, Atherosclerosis Rev., 5, 1
- Bulkley, 1975, Arch. Pathol., 99, 293
- Buja, 1979, Am. J. Pathol., 97, 327
- Bligh, 1959, Can. J. Biochem. Physiol., 37, 911, 10.1139/y59-099 · DOI · Paper page
- St. Clair, 1976, Atherosclerosis Rev., 1, 61
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Effect of Ca2+ Antagonist on Metabolism of Acetylated LDL in Macrophages
Sakata, N., Ohsuzu, F., 鈴川満雄, Ikewaki, K., & Nakamura, H. (1989) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.17.1_107
Non-reproductive system effects of progesterone and its non-selective antagonists mifepristone
Исаева, А. С. (2017) · Reproductive Endocrinology · doi:10.18370/2309-4117.2017.33.8-16
PET/MR imaging of hypoxic atherosclerotic plaque using 64Cu-ATSM
Nie, X. (2017) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7m9072q
mTORC1 Activates SREBP-2 through Maintenance of Endosomal Cycling and Suppression of Autophagy
Eid, W. (2017) · uO Research (University of Ottawa) · doi:10.20381/ruor-20753
Raizman, J. E. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-5733
Atherosclerosis: cellular mechanisms
Lutgens, E., Bochaton‐Piallat, M., & Weber, C. (2017) · doi:10.1093/med/9780198755777.003.0013
Atheroinflammatory Properties of LDL and HDL Particles Modified by Human Mast Cell Neutral Proteases
Maaninka, K. (2018) · Työväentutkimus Vuosikirja
The role of systemic metabolism in breast cancer progression
da Fonseca, C. S. R. D. S. G. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Schaefer, E. L., Zopyrus, N., Zielinski, Z. A. M., Facey, G. A., & Pratt, D. A. (2019) · Angewandte Chemie · doi:10.1002/ange.201914637
Low density lipoprotein subfraction with high negative charge
Denisenko, A. D., Silina, I. A., Dizhe, E. B., Vinogradov, A. G., & Klueva, N. N. (2001) · Medical academic journal · doi:10.17816/maj693487
The role of glycation and glycoxidation of low-density lipoproteins in foam cell formation.
Brown, B. E. (2004) · The Sydney eScholarship Repository (The University of Sydney)
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642026
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642035
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642029
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642023
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642020
Li, Y., Amrutkar, M., Finstadsveen, A. V., Dalen, K. T., Verbeke, C. S., & Gladhaug, I. P. (2024) · Figshare · doi:10.6084/m9.figshare.26642032
Paul, A. (2026) · Current Atherosclerosis Reports · doi:10.1007/s11883-026-01406-2
Bajpai, S. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/770d-5d08
Molecular Biology of Human Apolipoprotein B and Related Diseases
Zannis, V. I., Hussain, M. M., Hadzopoulou‐Cladaras, M., Kouvatsi, A., Kardassis, D., & Cladaras, C. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0733-4_14
Metadata
- Authors
- Brown, M. S., Ho, Y. K., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-10
- Volume
- 255
- Issue
- 19
- Pages
- 9344-9352
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1940775645
- Cited by
- 722
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 8
- FWCI
- 33.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- foam cells, cholesterol ester hydrolysis, re-esterification
- MeSH terms
- Acetylation, Ammonium Chloride, Animals, Cells, Cultured, Chloroquine, Cholesterol Esters, Female, Humans, Kinetics, Lipoproteins, HDL, Lipoproteins, LDL, Macrophages, Male, Progesterone, Tritium, Mice
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