Goldstein, Joseph L.

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 5,703

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 5,394

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 4,092

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Brown, M. S., & Goldstein, J. L. (1997) · Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 3,834

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

Brown, M. S., & Goldstein, J. L. (1983) · Annual Review of Biochemistry

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 2,300

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 1,871

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J. (1985) · Annual Review of Cell Biology

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 1,600

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., & Russell, D. W. (1984) · Cell

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 1,382

The LDL Receptor

Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 1,344

Regulated Intramembrane Proteolysis

Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L. (2000) · Cell

Alzheimer's disease research and treatmentsWnt/β-catenin signaling in development and cancer

Cited by 1,329

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Goldstein, J. L., & Brown, M. S. (2015) · Cell

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 1,233

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,038

Crucial Step in Cholesterol Homeostasis

Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 987

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 790

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 733

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

Brown, M. S., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and biosynthesis

Cited by 722

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 669

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

Basu, S. K., Goldstein, J. L., Anderson, R. G. W., & Brown, M. S. (1981) · Cell

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 589

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

Bilheimer, D. W., Grundy, S. M., Brown, M. S., & Goldstein, J. L. (1983) · Proceedings of the National Academy of Sciences

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 557

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

Brown, M. S., & Goldstein, J. L. (1983) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 545

Structure of the LDL Receptor Extracellular Domain at Endosomal pH

Rudenko, G., Henry, L., Henderson, K., Ichtchenko, K., Brown, M. S., Goldstein, J. L., & Deisenhofer, J. (2002) · Science

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 482

Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells

Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L., & Brown, M. S. (2001) · Journal of Biological Chemistry

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 448

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 445

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., et al. (1982) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 436