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The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.
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“the continual hydrolysis and re-esterification of droplet cholesterol constitutes a futile cycle that wastes ATP and thereby contributes to the premature death of the foam cells in poorly oxygenated regions of atherosclerotic lesions24,25.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [24]
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Henriksen, T., Mahoney, E. M., & Steinberg, D. H. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb25711.x · Cited by 111
Von Eckardstein, A., Langer, C., Engel, T., Schaukal, I., Cignarella, A., Reinhardt, J., Lorkowski, S., Li, Z., Zhou, X., Cullen, P., et al. (2001) · The FASEB Journal · doi:10.1096/fj.00-0798com · Cited by 95
Metadata
- Authors
- Brown, M. S., Ho, Y. K., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-10
- Volume
- 255
- Issue
- 19
- Pages
- 9344-9352
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1940775645
- Cited by
- 722
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 8
- FWCI
- 33.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- foam cells, cholesterol ester hydrolysis, re-esterification
- MeSH terms
- Acetylation, Ammonium Chloride, Animals, Cells, Cultured, Chloroquine, Cholesterol Esters, Female, Humans, Kinetics, Lipoproteins, HDL, Lipoproteins, LDL, Macrophages, Male, Progesterone, Tritium, Mice
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