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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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The liver expresses over 70% of whole body LDLR and is the major determinant of plasma LDL-C concentrations.
“The liver expresses over 70% of whole body LDLR and is the major determinant of plasma LDL-C concentrations3,4.”
From RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels (2023) · cites this paper as [3]
In the ER, LDL-derived cholesterol is esterified with a fatty acid for storage as cholesteryl esters in lipid droplets.
“is esterified with a fatty acid for storage as cholesteryl esters in lipid droplets (3, 4).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [3]
The receptor exhibits the same characteristic properties as the LDL receptor on human fibroblasts.
“This receptor exhibits the same characteristic properties as the LDL receptor on human fibroblasts (Goldstein and Brown, 1977).”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Goldstein and Brown, 1977
The LDL receptor on brain capillary endothelial cells exhibits the same characteristic properties as the LDL receptor on human fibroblasts.
“This receptor exhibits the same characteristic properties as the LDL recep- tor on human fibroblasts (Goldstein and Brown, 1977).”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Goldstein and Brown, 1977
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RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels
Clifford, B. L., Jarrett, K. E., Cheng, J., Cheng, A., Seldin, M., Morand, P., Lee, R., Chen, M., Baldan, A., de Aguiar Vallim, T. Q., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.321938 · Cited by 20
Metadata
- Authors
- Goldstein, L. J., & Brown, S. M.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1977-06
- Volume
- 46
- Issue
- 1
- Pages
- 897-930
- ISSN
- 0066-4154
- 1545-4509
- Cited by
- 1,906
- References
- 0
- Language
- en
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