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Cited by 365

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.

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Windler, E., Chao, Y., Havel, R.J.·1980·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)70811-4
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Abstract

The uptake and metabolism of lymphatic large chylomicrons from fat-fed rats, lymphatic small chylomicrons from glucose-fed rats, and hepatic very low density lipoproteins from perfusates of isolated livers, and of remnants produced from these lipoproteins in functionally eviscerated rats were studied in the isolated perfused rat liver. All lipoproteins were labeled isotopically in their cholesteryl ester and triglyceride moieties. Uptake of the labeled lipids or large chylomicrons was slow and limited, but these lipids in small chylomicrons and hepatic very low density lipoproteins were taken up and metabolized progressively and at equal rates. Incubation with very low density lipoprotein-free plasma increased the content of C apolipoproteins in small chylomicrons and hepatic very low density lipoproteins and greatly retarded the hepatic uptake of their labeled lipids. In remnants from all sources, which are depleted of C apolipoproteins but not of apolipoprotein E, the labeled lipids were rapidly taken up and metabolized. Neither extensive hydrolysis of core triglycerides nor the production of monoglycerides was required for this rapid hepatic uptake. These results are consistent with the hypothesis that one or more of the C apolipoproteins opposes and apolipoprotein E promotes recognition of triglyceride-rich lipoproteins by a hepatic receptor.

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Metadata

Authors
Windler, E., Chao, Y., & Havel, R. J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1980-06
Volume
255
Issue
11
Pages
5475-5480
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)70811-4
OpenAlex
W160088592
Cited by
365
References
39
FWCI
30.69
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat. https://app.cochat.ai/papers/10.1016/s0021-9258(19)70811-4
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Windler, E., Chao, Y., & Havel, R. J. (1980). Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)70811-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.