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Regulation of Plasma Cholesterol by Lipoprotein Receptors

Brown, Michael S., Kovanen, Petri T., Goldstein, Joseph L.·1981·Science
DOI 10.1126/science.6261329
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Abstract

The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.

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Metadata

Authors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L.
Affiliations
University of Texas Health Science Center, Dallas 75235
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1981-05-08
Volume
212
Issue
4495
Pages
628-635
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.6261329
Cited by
702
References
3
Language
en

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