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Evaluation of quadrupole time-of-flight tandem mass spectrometry and ion-trap multiple-stage mass spectrometry for the differentiation of C-glycosidic flavonoid isomers
Open accessAbstract
LC-MS-MS is becoming a very important tool for the on-line identification of natural products in crude plant extracts. For an efficient use of this technique in the dereplication of natural products, a careful study of the parameters used to generate informative MS-MS spectra is needed. In this paper, the collision-induced dissociation (CID) MS-MS spectra of ubiquitous C-glycosidic flavonoids have been systematically studied using hybrid quadrupole time-of-flight and ion-trap (IT) mass analysers under various CID energy conditions. Efficient differentiation of flavonoid C-glycoside isomers was possible, based on the comparison of CID-MS-MS spectra of particular C-glycoside unit fragments. Striking differences between 6-C and 8-C flavonoid glycosides were especially observed in the product ion spectra of their 0.2X+ fragments ([M+H-120]+). Some guidelines for the on-line characterisation of C-glycosidic flavonoids by LC-MS-MS or LC-multiple-stage MS are given.
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Cited by
Han, J., Ye, M., Qiao, X., Xu, M., Wang, B.-R., & Guo, D.-A. (2008) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2008.02.013 · Cited by 165
Hybrid Search: A Method for Identifying Metabolites Absent from Tandem Mass Spectrometry Libraries
Cooper, B. T., Yan, X., Simón-Manso, Y., Tchekhovskoi, D. V., Mirokhin, Y. A., & Stein, S. E. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03415 · Cited by 69
Pandey, R., & Kumar, B. (2016) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2016.1148048 · Cited by 68
Metadata
- Authors
- Waridel, P., Wolfender, J.-L., Ndjoko, K., Hobby, K. R., Major, H. J., & Hostettmann, K.
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 926
- Issue
- 1
- Pages
- 29-41
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W1967677446
- Cited by
- 309
- References
- 0
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Waridel, P., Wolfender, J.-L., Ndjoko, K., Hobby, K. R., Major, H. J., & Hostettmann, K. (2001). Evaluation of quadrupole time-of-flight tandem mass spectrometry and ion-trap multiple-stage mass spectrometry for the differentiation of C-glycosidic flavonoid isomers. Journal of Chromatography A. https://doi.org/10.1016/s0021-9673(01)00806-8
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