The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides
Open accessAbstract
Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis. We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis. The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia. Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002). In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r = 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h. The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S(f) 60;-400) TRL apoB-100. The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)]. We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population. - Karpe, F., S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;-21.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As a result, elevated levels of cholesterol-enriched remnant lipoproteins contribute to the development of premature coronary [22,23,24] and peripheral [25,26] atherosclerosis.”
From Spectrum and Prevalence of Rare APOE Variants and Their Association with Familial Dysbetalipoproteinemia (2024) · cites this paper as [25]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Carlson, K. (1973) · Journal of Clinical Pathology · doi:10.1136/jcp.s1-5.1.32 · Cited by 420
Nakajima, K., SAITO, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., Campos, E. M., et al. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90062-9 · Cited by 417
Phillips, A. N., & Smith, G. D. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90155-3 · Cited by 275
Boquist, S., Ruotolo, G., Tang, R., Björkegren, J., Bond, M. G., Fairé, U. D., Karpe, F., & Hamsten, A. (1999) · Circulation · doi:10.1161/01.cir.100.7.723 · Cited by 258
Self-citationCampos, E. M., Nakajima, K., Tanaka, A., & Havel, R. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41527-5 · Cited by 185
Karpe, F., & Hamsten, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39974-0 · Cited by 182
Self-citationKarpe, F., Fairé, U. D., Mercuri, M. F., BOND, M., Hellénius, M.-L., & Hamsten, A. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00184-1 · Cited by 110
Self-citationKarpe, F., Hellénius, M.-L., & Hamsten, A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90076-8 · Cited by 97
Self-citationTriglycerides are more important in atherosclerosis than epidemiology has suggested
Durrington, P. N. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00219-6 · Cited by 72
Björkegren, J., Boquist, S., Samnegård, A., Lundman, P., Tornvall, P., Ericsson, C.-G., & Hamsten, A. (2000) · Circulation · doi:10.1161/01.cir.101.3.227 · Cited by 70
Self-citation
Research works printed but not linked: 1
- Nakajima, 1996, Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B and apo A-I, J. Clin. Ligand Assay, 19, 177
Cited by
Sorted by citations
Items 101–174 of 174
Postprandial remnant lipoproteins as targets for the prevention of atherosclerosis
Nakajima, K., & Tanaka, A. (2018) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000393 · Cited by 14
Association of Intima-Media Thickness of Carotid Arteries With Remnant Lipoproteins in Men and Women
Pitha, J. V., Kovář, J., Škodová, Z., Cífková, R., Stávek, P., Červenka, L., Šejda, T., Lánská, V., & Poledne, R. (2015) · Physiological Research · doi:10.33549/physiolres.933195 · Cited by 13
Postprandial plasma lipidome responses to a high-fat meal among healthy women
Yoshinaga, M. Y., Quintanilha, B. J., Chaves‐Filho, A. B., Miyamoto, S., Sampaio, G. R., & Rogero, M. M. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108809 · Cited by 12
Mihuta, M.-S., Paul, C., Ciulpan, A., Dacca, F., Velea, I. P., Mozos, I. M., & Stoian, D. L. (2021) · Applied Sciences · doi:10.3390/app112210721 · Cited by 13
Oi, K., Shimokawa, H., Hirakawa, Y., Tashiro, H., Nakaike, R., Kozai, T., Ohzono, K., Yamamoto, K., Koyanagi, S., Okamatsu, S., et al. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200407000-00009 · Cited by 13
Okazaki, M., Usui, S., Tokunaga, K., Nakajima, Y., Takeichi, S., Nakano, T., & Nakajima, K. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.10.008 · Cited by 12
Ose, L., Johnson‐Levonas, A. O., Reyes, R., Lin, J., Shah, A. K., Tribble, D. L., Musliner, T., & for the Vytorin Extension Study Group (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01402.x · Cited by 12
Okubo, M., Hanada, H., Matsui, M., Hidaka, Y., Masuda, D., Sakata, Y., & Yamashita, S. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.23309 · Cited by 11
Mills, C. E., Harding, S., Bapir, M., Mandalari, G., Salt, L. J., Gray, R., Fielding, B. A., Wilde, P. J., Hall, W. L., & Berry, S. E. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa413 · Cited by 11
Remnant Lipoproteins and Atherogenesis
Kawakami, A., Yoshida, M., Tanaka, A., Nakajima, K., Yasukochi, Y., Shimokado, K., & Numano, F. (2001) · Journal of atherosclerosis and thrombosis · doi:10.1111/j.1749-6632.2001.tb03964.x · Cited by 23
Emerging risk factors and early atherosclerosis indices in subjects with impaired glucose tolerance
Schaan, B. D., Portal, V. L., Ugarte, M. D., Dias, A., & Hatem, D. M. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70234-3 · Cited by 11
Cheng, Q., Sun, J., Zhong, H., Wang, Z., Liu, C., Zhou, S., & Deng, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1393333 · Cited by 15
Taguchi, M., Ishigami, M., Nishida, M., Moriyama, T., Yamashita, S., & Yamamura, T. (2011) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2011.010244 · Cited by 10
Yoshimura, N., Kinoshita, M., & Teramoto, T. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.no976 · Cited by 9
Bittner, V., Tripputi, M., Hsia, J. A., Gupta, H., & Steffes, M. W. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.01.025 · Cited by 9
Triglyceride-rich lipoprotein remnant levels and metabolism
Brinton, E. A., Nanjee, M. N., & Hopkins, P. N. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.04.001 · Cited by 9
Blokhina, A. V., Ershova, A. I., Kiseleva, A. V., Sotnikova, E. A., Zharikova, A. A., Zaicenoka, M., Vyatkin, Y. V., Ramensky, V. E., Kutsenko, V. A., Garbuzova, E. V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312651 · Cited by 8
Katada, S., Oishi, S., Yanagawa, K., Ishii, S., Oki, M., Matsui, Y., Osaki, N., Takano, K., & Hibi, M. (2021) · Food & Function · doi:10.1039/d1fo01917a · Cited by 8
Postprandial lipemia, diet, and cardiovascular risk
Rivellese, A. A., Bozzetto, L., & Annuzzi, G. (2008) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-009-0002-2 · Cited by 8
Trindade, M., Martucci, R. B., Burlá, A. K., Oigman, W., Neves, M. F., & Araújo, D. V. (2012) · International Journal of Hypertension · doi:10.1155/2012/257501 · Cited by 8
Perona, J. S., Cañizares, J., Montero, E., Sánchez-Domínguez, J. M., Pacheco, Y. M., & Ruiz-Gutiérrez, V. (2004) · Nutrition · doi:10.1016/j.nut.2004.03.008 · Cited by 8
Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol
Nomura, A., Tada, H., Nohara, A., Kawashiri, M., & Yamagishi, M. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42960 · Cited by 8
Riccardi, G., Bozzetto, L., & Annuzzi, G. (2006) · Scandinavian Journal of Food & Nutrition · doi:10.1080/17482970601080539 · Cited by 7
Is there any relationship between coronary artery disease and postprandial triglyceride levels?
Atar, I., Atar, İ., Aydınalp, A., Ertan, Ç., Bozbaş, H., Özin, B., Yı́ldı́rı́r, A., & Müderrisoğlu, H. (2011) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2011.053 · Cited by 7
Wang, A., Tian, X., Zuo, Y., Wu, J., Tang, H., Wang, Y., & Zhao, X. (2021) · Atherosclerosis Plus · doi:10.1016/j.athplu.2021.10.002 · Cited by 6
Zeng, N., Shen, Y., Li, Y., & Wang, Y. (2023) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2023.107234 · Cited by 6
Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease
Mugii, S., Hanada, H., Okubo, M., Masuda, D., Takeoka, K., Hidaka, Y., Ohama, T., Matsuyama, A., Nakagawa-Toyama, Y., Nishida, M., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12757 · Cited by 6
Maillot, F., Baulieu, F., Guilloteau, D., Boirie, Y., Garrigue, M. A., Hoinard, C., & Couet, C. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.014 · Cited by 6
Remnant Lipoprotein Density Profiling by CsBiEDTA Density Gradient Ultracentrifugation
Chandra, R., & Macfarlane, R. D. (2005) · Analytical Chemistry · doi:10.1021/ac050775w · Cited by 6
Le, N. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f20df8 · Cited by 6
Shoji, K., Yamasaki, M., & Kunitake, H. (2020) · Journal of Oleo Science · doi:10.5650/jos.ess19201 · Cited by 5
Williams, K. J., & Fisher, E. A. A. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch24 · Cited by 5
Epidemiology of macrovascular disease and hypertension in diabetes mellitus
Tuomilehto, J. O., Rastenytė, D., Qiao, Q., Barengo, N. C., & Matz, K. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch69 · Cited by 5
Roever, L. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.03.019 · Cited by 4
Bhoite, R. (2020) · Journal of Diabetes & Metabolism · doi:10.35248/2155-6156.20.11.841 · Cited by 4
Riccardi, G., Bozzetto, L., & Annuzzi, G. (2006) · Food & Nutrition Research · doi:10.3402/fnr.v50i0.1583 · Cited by 4
Fu, H., Wei, X., & Wirtz, S. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1718199 · Cited by 3
Nakajima, K. (2014) · Clinical & Experimental Thrombosis and Hemostasis · doi:10.14345/ceth.14013 · Cited by 4
Postprandial implications in cardiovascular disease and potential markers to develop new therapies
Tudorache, I. F., Barbarossa, D., Daraban, B. S., Rizzo, R., Esposito, F. M., Coronelli, M. M., & Catapano, A. L. (2025) · European Atherosclerosis Journal · doi:10.56095/eaj.v4i2.104 · Cited by 2
Byrne, P., Lin, T., Jones, M., Demasi, M., Saif-Ur-Rahman, K., & DuBroff, R. J. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.03.026 · Cited by 2
Huang, X., Sun, T., Zhang, B., Ma, M., Chen, Z., Zhao, Z., Dong, S., & Zhou, Y. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2458200 · Cited by 2
Shkurashivska, S. V., & Еrstenyuk, H. M. (2015) · Medical and Clinical Chemistry · doi:10.11603/mcch.2410-681x.2015.v17.i4.5681 · Cited by 2
Exercise Intensity and Postprandial Lipemia (La intensidad del ejercicio y la lipemia postprandial)
Littlefield, L. A., & Grandjean, P. W. (2015) · Retos · doi:10.47197/retos.v0i27.34380 · Cited by 2
Schindhelm, R. K. (2007) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 2
Pathophysiology of adipose tissue metabolism and atherosclerosis in familial combined hyperlipidemia
Ylitalo, K. (2001) · Työväentutkimus Vuosikirja · Cited by 2
Li, W., Gao, K., Zhang, H., 王鹏程, Wang, H., & Tong, X. (2026) · Scientific Reports · doi:10.1038/s41598-026-38210-6 · Cited by 1
Relationship between Childhood and Adolescent Obesity and Remnant Lipoprotein
Choi, Y. J., Jo, Y. E., Kim, Y. K., Ahn, S. M., Baik, S. H., Jung, S. H., Kim, H. J., Chung, Y., Lee, K. W., & Kim, D. J. (2006) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2006.21.4.311 · Cited by 1
Serum esterified cholesterol subfractions as a risk marker for coronary artery disease
Gulati, D., Aggrawal, M., Gopinath, M., & Harith, A. K. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns1.6263 · Cited by 1
Lipids, Atherogenic Dyslipidemia, and Therapy
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch13 · Cited by 1
Friday, K. E. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0073-8 · Cited by 1
Expression of an atherogenic dyslipidemic phenotype in the postprandial period
Twickler, M., Cramer, M. J., & Erkelens, W. D. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03019-9 · Cited by 1
Granér, M. (2007) · Työväentutkimus Vuosikirja
Fatty acid metabolism in the metabolic syndrome : effects of dietary fat quantity and quality
van Hees, A. M. J. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20111111ah
Cheung, C.-L. (2009) · Research Online (University of Wollongong)
A study of omega-3 fatty acid therapy in patients with nephrotic syndrome
Siddiqui, S. (2008) · Enlighten: Theses (The University of Glasgow)
Relação da lipemia pós prandial com aterosclerose avaliada pela angiotomografia coronária
Staniak, H. L. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-04042014-095144
Johansen, C. T., MacDonald, A., & Hegele, R. A. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0025307
Jovičić, S. Ž. (2008) · Journal of Medical Biochemistry · doi:10.2478/v10011-007-0044-2
[Role of RLP-induced inflammation in atherosclerosis].
Yoshida, M. (2007) · Nihon yakurigaku zasshi. Folia pharmacologica Japonica · doi:10.1254/fpj.129.167
Lipoprotein Metabolism in Insulin-Resistant States
Avramoglu, R. K., Basciano, H., & Adeli, K. (2006) · Springer eBooks · doi:10.1007/0-387-36279-3_11
Novel factors affecting clearance of triacylglycerol-rich lipoproteins from blood
Nilsson, S. K. (2010)
Utilization of Lipoprotein Subfractions
Cromwell, W. C., & Otvos, J. D. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-533-6_15
Oliveira, T., Santos, C. A. G. D., Pompeu, M., Sá, B. D. O., Gomes, R. A. F., Célia, A., Santos, O., Cipriano, D. D. O., & Original, A. (2009)
The Role of Fetuin-A in Disease Processes Prevalent in Postmenopausal Women
Bane, A. A., & Grandjean, P. W. (2015) · Dialnet (Universidad de la Rioja)
Key Therapeutic Targets in Chronic Cardiac Care
BA, B. S. S., BHSc Sally Inglis, B. N., & BSc, A. H. (2006) · Wiley eBooks · doi:10.1002/9780470750599.ch2
Fatty acid metabolism in the metabolic syndrome
Blaak, E. E., Saris, W. H. M., & van Hees, A. M. J. (2005)
The Acute Regulation of Intestinal Chylomicron Secretion by Glucagon-like Peptides
Hsieh, J. (2012) · TSpace (University of Toronto)
(2018) · Wiley eBooks · doi:10.1002/9781118829875.refs
(2002) · Circulation · doi:10.1161/circ.106.25.3373
(2005) · Wiley eBooks · doi:10.1002/9780470774663.refs
Moriyama, K., Masuda, Y., Suzuki, N., Yamada, C., Kishimoto, N., Takashimizu, S., Akira, K. U. B. O., & Nishizaki, Y. (2022) · Health Evaluation and Promotion · doi:10.7143/jhep.2022-20
Development and validation of a nomogram model for predicting postprandial hypertriglyceridemia
Gu, W., Shi, L., Li, X., Zheng, K., & Song, G. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1622385
Petrenya, N. (2012) · NORA - Norwegian Open Research Archives
Metadata
- Authors
- Karpe, F., Boquist, S., Tang, R., Bond, G. M., de Faire, U., & Hamsten, A.
- Affiliations
- Karolinska Institutet (SE)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Karpe, Fredrik
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 42
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1936800019
- Cited by
- 174
- References
- 14
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- remnant-like particle cholesterol, remnant lipoproteins, triglyceride-rich lipoproteins, carotid intima-media thickness, atherosclerosis, LDL cholesterol, plasma triglycerides, postprandial lipemia, apolipoprotein B-48, apolipoprotein B-100, high-fat meal, middle-aged men
- MeSH terms
- Apolipoproteins, Arteriosclerosis, Carotid Arteries, Cholesterol, Fasting, Humans, Lipoproteins, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Ultrasonography, Cohort Studies, Linear Models, Tunica Intima
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
