Cited by 324Fatty Acid Research and HealthLipid metabolism and biosynthesisCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

Open access

de Vries, J E, Vork, M M, Roemen, T H, de Jong, Y F, Cleutjens, J P, van der Vusse, G J, van Bilsen, M·1997·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)37421-6

Open this paper in CoChat — free account

Abstract

The energy need of cardiac muscle cells in vivo is largely covered by the oxidation of saturated and mono-unsaturated fatty acids (FA). However, in vitro studies have shown that the saturated FA C16:0 at physiological concentrations exerts detrimental effects on primary cultures of neonatal rat ventricular myocytes by, as yet, unknown mechanisms. To evaluate the noxious effects of FA in more detail, neonatal cardiomyocytes were exposed to saturated (C16:0; C18:0) or mono-unsaturated (C16:1; cis-C18:1; trans-C18:1) FA, or combinations thereof for up to 48 h. FA (0.5 mM) complexed to bovine serum albumin (BSA) (0.15 mM) were added to a glucose-containing defined medium. Irrespective of the length and degree of unsaturation of the aliphatic chain, FA supplied to the cells were readily incorporated in the phospholipid pool. In the presence of mono-unsaturated FA, cardiomyocytes remained healthy and accumulated substantial amounts of triacylglycerol. In contrast, within 24 h after application of the saturated FA C16:0 or C18:0, cells had become irreversibly damaged, as evidenced by the presence of pyknotic nuclei and massive release of the cytosolic markers lactate dehydrogenase (LDH) and fatty acid-binding protein (FABP). Moreover, the occurrence of DNA-laddering indicated that apoptosis was involved. Induction of apoptotic cell death by C16:0 was counteracted by the co-administration of equimolar amounts of cis-C18:1, whereas trans-C18:1 delayed, but did not prevent, loss of cardiomyocyte viability. The present findings suggest that the incorporation of saturated, but not mono-unsaturated, fatty acids induces alterations in the phospholipid membrane, which initiate apoptotic cell death in neonatal cardiomyocytes.

Integrity signals

Registry

Crossref · 10.1016/s0022-2275(20)37421-6

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Some statistical methods useful in circulation research.
Wallenstein, S., Zucker, C. L., & Fleiss, J. L. (1980) · Circulation Research · doi:10.1161/01.res.47.1.1 · Cited by 3,867
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328
The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function
Stubbs, C. D., & Smith, A. D. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(84)90005-4 · Cited by 1,618
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
Neely, J. R., & Morgan, H. E. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.002213 · Cited by 1,266
Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.
Krown, K. A., Pagé, M., Nguyen, C., Zechner, D., Gutierrez, V., Comstock, K. L., Glembotski, C. C., Quintana, P. J. E., & Sabbadini, R. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119114 · Cited by 728
UV-Assay with Pyruvate and NADH
Bergmeyer, H. U., & Bernt, E. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50010-4 · Cited by 617
Fatty acid homeostasis in the normoxic and ischemic heart
Vusse, G. J., Glatz, J. F. C., Stam, H. C., & Reneman, R. S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.4.881 · Cited by 516
Chapter 1 Anatomical Methods in Cell Death
Kerr, J. F. R., Gobe, G. C., Winterford, C. M., & HARMON, B. V. (1995) · Methods in cell biology · doi:10.1016/s0091-679x(08)61921-4 · Cited by 469
Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule
Cistola, D. P., Hamilton, J. A., Jackson, D., & SMALL, D. M. (1988) · Biochemistry · doi:10.1021/bi00406a013 · Cited by 450

Show all 47 references

Research works printed but not linked: 2

De Vries, 1995, Saturated, but not mono-unsaturated, fatty acids induce cell death in neonatal rat ventricular cardiomyocytes. Eur, J. Physiol., S430:, R67
Goligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. M. Shevarh, and W. Strober, editors. 1991. Current Protocols for Immunology. Greene Publishing Associates and Wiley-Interscience, New York. 3.17.7-3.17.8.

Sorted by citations

Items 101–200 of 323

Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity
Samad, F., Badeanlou, L., Shah, C., & Yang, G. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1_5 · Cited by 61
Peroxisome proliferator-activated receptor-γ protects ERBB2-positive breast cancer cells from palmitate toxicity
Kourtidis, A., Srinivasaiah, R., Carkner, R. D., Brosnan, M. J., & Conklin, D. S. (2009) · Breast Cancer Research · doi:10.1186/bcr2240 · Cited by 60
Fatty Acid-Induced Apoptosis in Neonatal Cardiomyocytes: Redox Signaling
Sparagna, G. C., Hickson-Bick, D. L., Buja, L. M., & McMillin, J. B. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601750100524 · Cited by 56
Protective effect of eicosapentaenoic acid on palmitate-induced apoptosis in neonatal cardiomyocytes
Leroy, C., Tricot, S., Lacour, B., & Grynberg, A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.07.009 · Cited by 56
High Glucose Alters Cardiomyocyte Contacts and Inhibits Myofibrillar Formation
Dyntar, D., Sergeev, P., Klisic, J., Ambühl, P. M., SCHAUB, M. C., & Donath, M. Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1904 · Cited by 55
Regulation of Stearoyl Coenzyme A Desaturase Expression in Human Retinal Pigment Epithelial Cells by Retinoic Acid
Samuel, W., Kutty, R. K., Nagineni, S., Gordon, J. S., Prouty, S. M., Chandraratna, R. A. S., & Wiggert, B. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103587200 · Cited by 55
Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids
Urso, C. J., & Zhou, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169093 · Cited by 54
Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
QIN, X., Tian, J., ZHANG, P., Fan, Y., CHEN, L., Guan, Y., FU, Y., Zhu, Y. Z., Chien, S., & Wang, N. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.014 · Cited by 54
Phosphorylation of cardiac protein kinase B is regulated by palmitate
Soltys, C.-L. M., Buchholz, L., Gandhi, M., Clanachan, A. S., Walsh, K., & Dyck, J. R. B. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00275.2002 · Cited by 54
S-Allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway
Hwang, Y. P., Kim, H. G., Choi, J. H., Truong, M., Chung, Y., Jeong, T. C., & Jeong, H. G. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.006 · Cited by 53
Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid–Induced Macrophage Cell Death through Enhancing Ceramide Production
Zhang, Y., Rao, E., Zeng, J., Hao, J., Sun, Y., Liu, S., Sauter, E. R., Bernlohr, D., Cleary, M. P., Suttles, J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601403 · Cited by 49
Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3′,5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Lin, B., Lin, X., Stachel, M., Wang, E., Luo, Y., Lader, J. M., Sun, X., Delmar, M., & Bu, L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00253 · Cited by 53
Diurnal variations in myocardial metabolism
Bray, M. S., & Young, M. E. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn054 · Cited by 52
Oleic acid mitigates TNF-α-induced oxidative stress in rat cardiomyocytes
Al‐Shudiefat, A. A., Sharma, A. K., Bagchi, A. K., Dhingra, S., & Singal, P. K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1447-z · Cited by 51
Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of Soybean and Lard Oil in rats
Nivala, A. M., Reese, L., Frye, M. A., Gentile, C. L., & Pagliassotti, M. J. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.001 · Cited by 52
Different “Weight” of Cardiac and General Adiposity in Predicting Left Ventricle Morphology
Iacobellis, G., Pond, C. M., & Sharma, A. M. (2006) · Obesity · doi:10.1038/oby.2006.192 · Cited by 49
Effects of Insulin Replacements, Inhibitors of Angiotensin, and PKCβ's Actions to Normalize Cardiac Gene Expression and Fuel Metabolism in Diabetic Rats
Arikawa, E., Ronald, C. W., Isshiki, K., Luptak, I., He, Z., Yasuda, Y., Maeno, Y., Patti, M., Weir, G. C., Harris, R. A., et al. (2007) · Diabetes · doi:10.2337/db06-0655 · Cited by 51
Effect of the fat composition of a single meal on the composition and cytotoxic potencies of lipolytically-releasable free fatty acids in postprandial plasma
Chung, B. H., Hennig, B., Cho, B. H. S., & Darnell, B. E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00168-3 · Cited by 50
Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway
Engelbrecht, A., Engelbrecht, P., Genade, S., Niesler, C. U., Page, C., Smuts, C. M., & Lochner, A. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.08.004 · Cited by 50
Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance
Ussher, J. R., Folmes, C. D. L., Keung, W., Fillmore, N., Jaswal, J. S., Cadete, V. J. J., Beker, D. L., Lam, V. H., Zhang, L., & Lopaschuk, G. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037703 · Cited by 51
Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid
Labarthe, F., Khairallah, M., Bouchard, B., Stanley, W. C., & Rosiers, C. D. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00722.2004 · Cited by 49
Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes
Zheng, X., Ho, Q. W. C., Chua, M., Stelmashenko, O., Yeo, X. Y., Muralidharan, S., Torta, F., Chew, E. G. Y., Lian, M. M., Foo, J. N., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113074119 · Cited by 48
Effects of free fatty acids on insulin secretion in obesity
Zraika, S., Dunlop, M., Proietto, J., & Andrikopoulos, S. (2002) · Obesity Reviews · doi:10.1046/j.1467-789x.2002.00062.x · Cited by 47
Stearic acid metabolism in human health and disease
Shen, X., Miao, S., Zhang, Y., Guo, X., Li, W., Mao, X., & Zhang, Q. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.012 · Cited by 54
Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis
Johnson, E. S., Lindblom, K., Robeson, A. C., Stevens, R. D., Ilkayeva, O., Newgard, C. B., Kornbluth, S. A., & Andersen, J. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437210 · Cited by 45
Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis
Alamri, H., Patterson, N. H., Yang, E., Zoroquiaín, P., Lazaris, A., Chaurand, P., & Metrakos, P. P. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-1506-8 · Cited by 44
Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids*
Lockridge, J. B., Sailors, M. L., Durgan, D. J., Egbejimi, O., Jeong, W. J., Bray, M. S., Stanley, W. C., & Young, M. E. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700517-jlr200 · Cited by 42
Fatty Acid-Specific Fluorescent Probes and Their Use in Resolving Mixtures of Unbound Free Fatty Acids in Equilibrium with Albumin
Huber, A. H., Kampf, J. P., Kwan, T., Zhu, B., & Kleinfeld, A. M. (2006) · Biochemistry · doi:10.1021/bi060703e · Cited by 43
Expression of Adipocyte Biomarkers in a Primary Cell Culture Models Reflects Preweaning Adipobiology
Chu, D., Malinowska, E., Gawrońska‐Kozak, B., & Kozak, L. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555821 · Cited by 42
Insulin Protects Liver Cells from Saturated Fatty Acid-Induced Apoptosis via Inhibition of c-Jun NH2 Terminal Kinase Activity
Pagliassotti, M. J., Wei, Y., & Wang, D. (2007) · Endocrinology · doi:10.1210/en.2006-1710 · Cited by 43
Cardiac cell death in early diabetes and its modulation by dietary fatty acids
Ghosh, S., & Rodrigues, B. B. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.08.010 · Cited by 43
Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells
Hess, D., & Igal, R. A. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010265 · Cited by 42
Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia–reperfusion injury in cardiomyocytes
Barba, I., Chavarria, L., Ruiz‐Meana, M., Mirabet, M., Agulló, E., & David Garcia-dorado, A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163311 · Cited by 42
N-Myristoylation targets dihydroceramide Δ4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid
Beauchamp, E., Tekpli, X., Marteil, G., Lagadic‐Gossmann, D., Legrand, P., & Rioux, V. (2009) · Biochimie · doi:10.1016/j.biochi.2009.07.014 · Cited by 42
Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry
Bowden, J. A., Albert, C. J., Barnaby, O. S., & Ford, D. A. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.06.015 · Cited by 41
Bax signaling regulates palmitate-mediated apoptosis in C2C12myotubes
Peterson, J. M., Wang, Y., Bryner, R. W., Williamson, D. L., & Alway, S. E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00738.2007 · Cited by 42
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage
Thiele, A., Luettges, K., Ritter, D., Beyhoff, N., Smeir, E., Grune, J., Steinhoff, J. S., Schupp, M., Klopfleisch, R., Rothe, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab182 · Cited by 40
Transforming Growth Factor-β Regulates Stearoyl Coenzyme A Desaturase Expression through a Smad Signaling Pathway
Samuel, W., Nagineni, C. N., Kutty, R. K., Parks, W. T., Gordon, J. S., Prouty, S. M., Hooks, J. J., & Wiggert, B. O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108730200 · Cited by 39
Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway
Wei, C., Li, Y., ZHENG, H.-Y., TONG, Y.-Q., & Dai, W. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1276 · Cited by 40
Effect of the rooster semen enrichment with oleic acid on the quality of semen during chilled storage
Eslami, M., Ghaniei, A., & Rad, H. M. (2016) · Poultry Science · doi:10.3382/ps/pew041 · Cited by 38
Muscle fatty acid-binding protein
Zanotti, G. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00163-8 · Cited by 38
Heart-type fatty acid-binding protein (H-FABP) and coronary heart disease
Das, U. N. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2015.07.030 · Cited by 37
AMPK Prevents Palmitic Acid‐Induced Apoptosis and Lipid Accumulation in Cardiomyocytes
Adrian, L., Lenski, M., Tödter, K., Heeren, J., Böhm, M., & Laufs, U. (2017) · Lipids · doi:10.1007/s11745-017-4285-7 · Cited by 35
High Cholesterol Diet‐Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue
Sözen, E., Yazgan, B., Şahin, A., İnce, Ü., & Özer, N. K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8520746 · Cited by 37
Cloning, tissue distribution and hormonal regulation of stearoyl-CoA desaturase in tilapia, Oreochromis mossambicus*
Hsieh, S., Chang, H. T., Wu, C. H., & Kuo, C. M. (2003) · Aquaculture · doi:10.1016/s0044-8486(03)00408-3 · Cited by 36
Up-Regulation of the Cardiac Lipid Metabolism at the Onset of Heart Failure
AbdAlla, S., Fu, X., Elzahwy, S. S., Klaetschke, K., Streichert, T., & Quitterer, U. (2011) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152511797037583 · Cited by 39
Trans-right ventricle and transpulmonary metabolite gradients in human pulmonary arterial hypertension
Chouvarine, P., Giera, M. A., Kastenmüller, G., Artati, A., Adamski, J., Bertram, H., & Hansmann, G. (2020) · Heart · doi:10.1136/heartjnl-2019-315900 · Cited by 35
Full‐length adiponectin protects hepatocytes from palmitate‐induced apoptosis via inhibition of c‐Jun NH2 terminal kinase
Jung, T. W., Lee, Y. J., Lee, M. W., Kim, S. M., & Jung, T. W. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06955.x · Cited by 35
On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria
Belosludtsev, K. N., Saris, N.-E. L., Andersson, L. C., Belosludtseva, N. V., Agafonov, A. V., Sharma, A., Moshkov, D. A., & Mironova, G. D. (2006) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9010-9 · Cited by 35
Myocardial injury with biomarker elevation in diabetic ketoacidosis
Møller, N., Foss, C. H., Gravholt, C. H., Mortensen, U. M., Poulsen, S. H., & Mogensen, C. E. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.04.003 · Cited by 35
Cardiac Fatty Acid Metabolism and the Induction of Apoptosis
Sparagna, G. C., & Hickson-Bick, D. L. M. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40567-1 · Cited by 35
Increased Myocardial Susceptibility to Repetitive Ischemia With High‐fat diet‐induced Obesit
Thakker, G. D., Frangogiannis, N. G., Zymek, P. T., Sharma, S., Raya, J. L., Barger, P. M., Taegtmeyer, H., Entman, M. L., & Ballantyne, C. M. (2008) · Obesity · doi:10.1038/oby.2008.414 · Cited by 35
Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells
Sharmin, M. M., Mizusawa, M., Hayashi, S., Arai, W., Sakata, S., & Yonekura, S. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-18080 · Cited by 34
Obese Rats Exhibit High Levels of Fat Necrosis and Isoprostanes in Taurocholate-Induced Acute Pancreatitis
Pereda, J., Pérez, S., Escobar, J., Arduini, A., Asensi, M. A., Serviddio, G., Sabater-Orti, L., Aparisi, L., & Sastre, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044383 · Cited by 34
Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27
Lee, S. W., Rho, J. H., Lee, S. Y., Chung, W. T., Oh, Y. J., Kim, J. H., Yoo, S. H., Kwon, W. Y., Bae, J. Y., Seo, S. Y., et al. (2018) · Bone Research · doi:10.1038/s41413-018-0020-0 · Cited by 33
RalA and PLD1 Promote Lipid Droplet Growth in Response to Nutrient Withdrawal
Hussain, S. S., Tran, T.-M., Ware, T. B., Luse, M. A., Prevost, C. T., Ferguson, A. N., Kashatus, J. A., Hsu, K., & Kashatus, D. F. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109451 · Cited by 32
Exocrine pancreas ER stress is differentially induced by different fatty acids
Danino, H., Ben-Dror, K., & Birk, R. Z. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.09.022 · Cited by 35
A fluorogenic complementation tool kit for interrogating lipid droplet–organelle interaction
Li, X., Gamuyao, R., Wu, M.-L., Cho, W. J., King, S. V., Petersen, R. A., Stabley, D. R., Lindow, C., Climer, L. K., Shirinifard, A., et al. (2024) · Journal of Cell Biology · doi:10.1083/jcb.202311126 · Cited by 31
Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity
Tchkonia, T., Corkey, B. E., & Kirkland, J. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-32164-6_6 · Cited by 31
Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction
Yamamoto, T., Endo, J., Kataoka, M., Matsuhashi, T., Katsumata, Y., Shirakawa, K., Yoshida, N., Isobe, S., Moriyama, H., Goto, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208396 · Cited by 30
Human fetal intestinal epithelial cells metabolize and incorporate branched chain fatty acids in a structure specific manner
Liu, L., Wang, Z., Park, H. G., Xu, C., Lawrence, P., Su, X., Wijendran, V., Walker, W. A., Kothapalli, K. S. D., & Brenna, J. T. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.12.002 · Cited by 28
Evaluation of ram semen enrichment with oleic acid on different spermatozoa parameters during low temperature liquid storage
Hashem, E. Z., Haddad, R., & Eslami, M. (2017) · Small Ruminant Research · doi:10.1016/j.smallrumres.2017.03.002 · Cited by 29
Silymarin Prevents Palmitate‐Induced Lipotoxicity in HepG2 Cells: Involvement of Maintenance of Akt Kinase Activation
Song, Z., Song, M., Lee, D. Y. W., Liu, Y., Deaciuc, I. V., & McClain, C. J. (2007) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00116.x · Cited by 30
Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent
MacRae, V. E., Burdon, T., Ahmed, S. F., & Farquharson, C. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06958 · Cited by 29
The origin of 1H NMR‐visible triacylglycerol in human neutrophils
Wright, L. C., Obbink, K. L. G., Delikatny, E. J., Santangelo, R. T., & Sorrell, T. C. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.00955.x · Cited by 29
Lipid-cell interactions in human monocytes investigated by doubly-resonant coherent anti-Stokes Raman scattering microscopy
Weeks, T. J., Schie, I. W., Rutledge, J. C., Huser, T. R., & den Hartigh, L. J. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3544585 · Cited by 28
Regulation of lipid accumulation in 3T3-L1 cells: insulin-independent and combined effects of fatty acids and insulin
Kokta, T. A., Strat, A. L., Papasani, M. R., Szasz, J. I., Dodson, M. V., & Hill, R. A. (2007) · animal · doi:10.1017/s1751731107000936 · Cited by 28
Comparison of different carrier-compounds and varying concentrations of oleic acid on freezing tolerance of ram spermatozoa in tris-citric acid-egg yolk plasma semen diluent
Mortazavi, S.-H., Eslami, M., & Farrokhi‐Ardabili, F. (2020) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2020.106533 · Cited by 28
Molecular cloning of full-length cDNA encoding delta-9 desaturase through PCR strategies and its genomic organization and expression in grass carp (Ctenopharyngodon idella)
Chang, B., Hsieh, S., & Kuo, C.-M. (2001) · Molecular Reproduction and Development · doi:10.1002/1098-2795(200103)58:3 · Cited by 28
The Effect of Glycation on Epidermal Lipid Content, Its Metabolism and Change in Barrier Function
Yokota, M., & Tokudome, Y. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000448121 · Cited by 27
Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways
Wei, C. D., Li, Y., Zheng, H., Sun, K. S., Tong, Y. Q., Dai, W., Wu, W., & Bao, A. Y. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-135 · Cited by 27
Differential behaviour of epicardial adipose tissue-secretomes with high and low orosomucoid levels from patients with cardiovascular disease in H9C2 cells
Lage, R., Moscoso, I., Fernández‐Trasancos, Á., Cebro-Márquez, M., Couselo‐Seijas, M., Fandiño‐Vaquero, R., Bravo, S. B., Sierra, J. C., González‐Juanatey, J. R., & Eirás, S. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.025 · Cited by 26
Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in cardiomyoblasts
Chen, Y.-P., Tsai, C.-W., Shen, C.-Y., Day, C. H., Yeh, Y., Chen, R., Ho, T., Padma, V. V., Kuo, W., & Huang, C. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.007 · Cited by 26
Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats
Dong, M., Xu, X., Huang, Q., Lei, H., Xu, G., Ma, J., Hatzakis, E., Wang, X., & Zhang, L. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00316 · Cited by 26
SmD3 Regulates Intronic Noncoding RNA Biogenesis
Scruggs, B. S., Michel, C. I., Ory, D. S., & Schaffer, J. E. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00022-12 · Cited by 25
Palmitoleate enhances quality of rooster semen during chilled storage
Rad, H. M., Eslami, M., & Ghanie, A. (2015) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2015.12.003 · Cited by 25
Regulation of Hypothalamic-Pituitary-Adrenal Axis by Circulating Free Fatty Acids in Male Wistar Rats: Role of Individual Free Fatty Acids
Oh, Y. T., Kim, J., Kang, I., & Youn, J. H. (2013) · Endocrinology · doi:10.1210/en.2013-1700 · Cited by 24
The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation
Xia, M., Wu, Z., Wang, J., Buist‐Homan, M., & Moshage, H. J. (2023) · Antioxidants · doi:10.3390/antiox12111922 · Cited by 23
Abnormalities of the cardiac stem and progenitor cell compartment in experimental and human diabetes
Leonardini, A., & Avogaro, A. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.798334 · Cited by 23
Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress‐activated protein kinases and nuclear factor‐κB
Yang, M., Dai, J., Jia, Y., Suo, L., Li, S., Guo, Y., Liu, H., Li, L., & Yang, G. (2014) · FEBS Journal · doi:10.1111/febs.12853 · Cited by 23
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids
Ruiz, M., Palmgren, H., Henricsson, M., Devkota, R., Jaiswal, H., Maresca, M., Bohlooly‐Y, M., Peng, X., Borén, J., & Pilon, M. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158884 · Cited by 23
Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells
Landau, Z., Forti, E., Alcaly, M., & Birk, R. Z. (2006) · APOPTOSIS · doi:10.1007/s10495-006-5425-3 · Cited by 23
Chemoselective Acylation of Fully Deprotected Hydrazino Acetyl Peptides. Application to the Synthesis of Lipopeptides
Bonnet, D., Ollivier, N., Gras‐Masse, H., & Melnyk, O. (2000) · The Journal of Organic Chemistry · doi:10.1021/jo0010577 · Cited by 23
Fatty acids and cardiac disease: fuel carrying a message
van Bilsen, M., & Planavila, A. (2014) · Acta Physiologica · doi:10.1111/apha.12308 · Cited by 22
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension
Singh, N., Shafiq, M., Jagavelu, K., & Hanif, K. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111569 · Cited by 22
Tethering Fat: Tethers in Lipid Droplet Contact Sites
Bohnert, M. (2020) · Contact · doi:10.1177/2515256420908142 · Cited by 23
Canagliflozin and Dapagliflozin Attenuate Glucolipotoxicity-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Inhibition of Sodium-Glucose Cotransporter-1
Dasari, D., Bhat, A., Mangali, S., Ghatage, T., Lahane, G. P., Sriram, D., & Dhar, A. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00207 · Cited by 24
Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1)
KONDOH, Y., Kawada, T., & Urade, R. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.01.012 · Cited by 22
cDNA nucleotide sequence coding for stearoyl‐CoA desaturase and its expression in the zebrafish (Danio rerio) embryo
Hsieh, S., Liu, R. W., Wu, C. H., Cheng, W. T. F., & Kuo, C. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.10358 · Cited by 22
Pharmacokinetics and pharmacodynamics of glyburide in young and elderly nondiabetic adults.
Schwinghammer, T. L., Antal, E. J., Kubacka, R. T., Hackimer, M. E., & Johnston, J. M. (1991) · PubMed · Cited by 22
In Vivo Lipid Profiling Using Proton Magnetic Resonance Spectroscopy in an Experimental Liver Fibrosis Model
Cheung, J. S., Fan, S. J., Gao, D. S., Chow, A. M., Yang, J., Man, K., & Wu, E. X. (2010) · Academic Radiology · doi:10.1016/j.acra.2010.10.012 · Cited by 21
The role of dietary fatty acids in predicting myocardial structure in fat-fed rats
Jeckel, K. M., Miller, K. E., Chicco, A. J., Chapman, P. L., Mulligan, C. M., Falcone, P. H., Miller, M. L., Pagliassotti, M. J., & Frye, M. A. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-92 · Cited by 21
Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding
Suzuki, J., Ueno, M., Uno, M., Hirose, Y., Zenimaru, Y., Takahashi, S., Osuga, J.-I., Ishibashi, S., Takahashi, M., Hirose, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91031.2008 · Cited by 21
Inactivation of peroxisome proliferator-activated receptor isoforms α, β/δ, and γ mediate distinct facets of hypertrophic transformation of adult cardiac myocytes
Pellieux, C., Montessuit, C., Papageorgiou, I., & Lerch, R. A. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0297-0 · Cited by 21
Differential effects of high-fat diet on myocardial lipid metabolism in failing and nonfailing hearts with angiotensin II-mediated cardiac remodeling in mice
Pellieux, C., Montessuit, C., Papageorgiou, I., Pedrazzini, T., & Lerch, R. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01023.2011 · Cited by 19
A novel function of bamboo extract in relieving lipotoxicity
Panee, J., Liu, W., Lin, Y., Gilman, C. A., & Berry, M. J. (2008) · Phytotherapy Research · doi:10.1002/ptr.2395 · Cited by 20
Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid
Yamasaki, M., Chujo, H., Nou, S., Tachibana, H., & Yamada, K. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00215-5 · Cited by 20
Palmitate alters neuregulin signaling and biology in cardiac myocytes
Miller, T. A., Icli, B., Cote, G. M., LeBrasseur, N. K., Borkan, S. C., Pimentel, D. R., Peng, X., & Sawyer, D. B. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.150 · Cited by 19
Rosiglitazone Inhibits Early Stage of Glucolipotoxicity-Induced Beta-Cell Apoptosis
Han, S. J., Kang, E. S., Hur, K. Y., Kim, H. J., Kim, S. H., Yun, C., Choi, S., Ahn, C. W., Soo, B., KANG, Y. Y., et al. (2008) · Hormone Research in Paediatrics · doi:10.1159/000137662 · Cited by 19
Enhanced radiosensitization of p53 mutant cells by oleamide
Lee, Y.-J., Chung, D.-Y., Lee, S., Jhon, G. J., & Lee, Y. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.11.033 · Cited by 19

Authors: de Vries, J. E., Vork, M. M., Roemen, T. H., de Jong, Y. F., Cleutjens, J. P., van der Vusse, G. J., & van Bilsen, M.
Affiliations: Maastricht University (NL)
ORCID: Cleutjens, J P
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1997-07
Volume: 38
Issue: 7
Pages: 1384-1394
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)37421-6
OpenAlex: W2407618083
Cited by: 324
References: 47
Citations by year: 2026: 2 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 7 · 2013: 21 · 2012: 16
FWCI: 6.75
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8484 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: saturated fatty acids, monounsaturated fatty acids, palmitic acid, stearic acid, cardiomyocyte apoptosis, neonatal rat ventricular myocytes, membrane damage, triglyceride accumulation, fatty acid oxidation, cardiotoxicity
MeSH terms: Fatty Acid-Binding Protein 7, Animals, Animals, Newborn, Carrier Proteins, Cells, Cultured, Culture Media, Fatty Acids, Fatty Acids, Monounsaturated, Glucose, Kinetics, L-Lactate Dehydrogenase, Myocardium, Neoplasm Proteins, Nerve Tissue Proteins, Phospholipids, Rats, Inbred WKY, Serum Albumin, Bovine, Triglycerides, Apoptosis, Myelin P2 Protein, Fatty Acid-Binding Proteins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks