Cited by 324Fatty Acid Research and HealthLipid metabolism and biosynthesisCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

Open access

de Vries, J E, Vork, M M, Roemen, T H, de Jong, Y F, Cleutjens, J P, van der Vusse, G J, van Bilsen, M·1997·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)37421-6

Open this paper in CoChat — free account

Abstract

The energy need of cardiac muscle cells in vivo is largely covered by the oxidation of saturated and mono-unsaturated fatty acids (FA). However, in vitro studies have shown that the saturated FA C16:0 at physiological concentrations exerts detrimental effects on primary cultures of neonatal rat ventricular myocytes by, as yet, unknown mechanisms. To evaluate the noxious effects of FA in more detail, neonatal cardiomyocytes were exposed to saturated (C16:0; C18:0) or mono-unsaturated (C16:1; cis-C18:1; trans-C18:1) FA, or combinations thereof for up to 48 h. FA (0.5 mM) complexed to bovine serum albumin (BSA) (0.15 mM) were added to a glucose-containing defined medium. Irrespective of the length and degree of unsaturation of the aliphatic chain, FA supplied to the cells were readily incorporated in the phospholipid pool. In the presence of mono-unsaturated FA, cardiomyocytes remained healthy and accumulated substantial amounts of triacylglycerol. In contrast, within 24 h after application of the saturated FA C16:0 or C18:0, cells had become irreversibly damaged, as evidenced by the presence of pyknotic nuclei and massive release of the cytosolic markers lactate dehydrogenase (LDH) and fatty acid-binding protein (FABP). Moreover, the occurrence of DNA-laddering indicated that apoptosis was involved. Induction of apoptotic cell death by C16:0 was counteracted by the co-administration of equimolar amounts of cis-C18:1, whereas trans-C18:1 delayed, but did not prevent, loss of cardiomyocyte viability. The present findings suggest that the incorporation of saturated, but not mono-unsaturated, fatty acids induces alterations in the phospholipid membrane, which initiate apoptotic cell death in neonatal cardiomyocytes.

Integrity signals

Registry

Crossref · 10.1016/s0022-2275(20)37421-6

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Some statistical methods useful in circulation research.
Wallenstein, S., Zucker, C. L., & Fleiss, J. L. (1980) · Circulation Research · doi:10.1161/01.res.47.1.1 · Cited by 3,867
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328
The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function
Stubbs, C. D., & Smith, A. D. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(84)90005-4 · Cited by 1,618
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
Neely, J. R., & Morgan, H. E. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.002213 · Cited by 1,266
Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.
Krown, K. A., Pagé, M., Nguyen, C., Zechner, D., Gutierrez, V., Comstock, K. L., Glembotski, C. C., Quintana, P. J. E., & Sabbadini, R. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119114 · Cited by 728
UV-Assay with Pyruvate and NADH
Bergmeyer, H. U., & Bernt, E. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50010-4 · Cited by 617
Fatty acid homeostasis in the normoxic and ischemic heart
Vusse, G. J., Glatz, J. F. C., Stam, H. C., & Reneman, R. S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.4.881 · Cited by 516
Chapter 1 Anatomical Methods in Cell Death
Kerr, J. F. R., Gobe, G. C., Winterford, C. M., & HARMON, B. V. (1995) · Methods in cell biology · doi:10.1016/s0091-679x(08)61921-4 · Cited by 469
Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule
Cistola, D. P., Hamilton, J. A., Jackson, D., & SMALL, D. M. (1988) · Biochemistry · doi:10.1021/bi00406a013 · Cited by 450

Show all 47 references

Research works printed but not linked: 2

De Vries, 1995, Saturated, but not mono-unsaturated, fatty acids induce cell death in neonatal rat ventricular cardiomyocytes. Eur, J. Physiol., S430:, R67
Goligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. M. Shevarh, and W. Strober, editors. 1991. Current Protocols for Immunology. Greene Publishing Associates and Wiley-Interscience, New York. 3.17.7-3.17.8.

Sorted by citations

Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 933
Ceramides in insulin resistance and lipotoxicity
Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 866
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
Kolwicz, S. C., Purohit, S., & Tian, R. (2013) · Circulation Research · doi:10.1161/circresaha.113.302095 · Cited by 838
A novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762
Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
Wei, Y., Wang, D., Topczewski, F., & Pagliassotti, M. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00644.2005 · Cited by 752
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
Holland, W. L., & Summers, S. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0025 · Cited by 604
Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
Listenberger, L. L., Ory, D. S., & Schaffer, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010286200 · Cited by 594
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
El-Assaad, W., Buteau, J., Peyot, M., Nolan, C. J., Roduit, R., Hardy, S., Joly, E. C., Dbaibo, G. S., Rosenberg, L. C., & Prentki, M. (2003) · Endocrinology · doi:10.1210/en.2003-0410 · Cited by 586
Distinct Effects of Saturated and Monounsaturated Fatty Acids on β-Cell Turnover and Function
Maedler, K., Spinas, G. A., Dyntar, D., Moritz, W., Kaiser, Ν., & Donath, M. Y. (2001) · Diabetes · doi:10.2337/diabetes.50.1.69 · Cited by 553
Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation
Cnop, M., Hannaert, J. C., Hoorens, A., Eizirik, D. L., & PIPELEERS, D. G. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1771 · Cited by 548
Mitochondrial energy metabolism in heart failure: a question of balance
Huss, J. M., & Kelly, D. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24405 · Cited by 532
Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis
Wang, D., Wei, Y., & Pagliassotti, M. J. (2005) · Endocrinology · doi:10.1210/en.2005-0570 · Cited by 539
Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH
Pierantonelli, I., & Svegliati‐Baroni, G. (2018) · Transplantation · doi:10.1097/tp.0000000000002480 · Cited by 473
A fatty acid desaturase modulates the activation of defense signaling pathways in plants
Kachroo, P., Shanklin, J., Shah, J., Whittle, E. J., & Klessig, D. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151258398 · Cited by 435
Diseases of liporegulation: new perspective on obesity and related disorders
Unger, R. H., & Orci, L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0590 · Cited by 429
Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes
Donath, M. Y., St�rling, J., Maedler, K., & Mandrup-Poulsen, T. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0450-y · Cited by 422
Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARβ/δ, but not PPARγ, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism
Gilde, A. J., van der Lee, K. A. J. M., Willemsen, P. H. M., Chinetti, G., van der Leij, F. R., Vusse, G. J., Staels, B., & van Bilsen, M. (2003) · Circulation Research · doi:10.1161/01.res.0000060700.55247.7c · Cited by 400
Lipotoxicity in the heart
Wende, A. R., & Abel, E. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.023 · Cited by 352
Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells
Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323
Sirt1 acts in association with PPAR to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
Planavila, A., Iglesias, R., Giralt, M., & Villarroya, F. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq376 · Cited by 331
As a Matter of Fat
Brookheart, R. T., Michel, C. I., & Schaffer, J. E. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.011 · Cited by 279
Cardiolipin and apoptosis
McMillin, J. B., & Dowhan, W. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00329-3 · Cited by 266
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
Gentile, C. L., & Pagliassotti, M. J. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.10.001 · Cited by 254
Plastidial Fatty Acid Signaling Modulates Salicylic Acid– and Jasmonic Acid–Mediated Defense Pathways in the Arabidopsis ssi2 Mutant
Kachroo, A., Lapchyk, L., Fukushige, H., Hildebrand, D. F., Klessig, D. F., & Kachroo, P. (2003) · The Plant Cell · doi:10.1105/tpc.017301 · Cited by 250
Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.
Hardy, S., Langelier, Y., & Prentki, M. (2000) · PubMed · Cited by 248
Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
ZHANG, L., Ge, L., Parimoo, S., Stenn, K. S., & Prouty, S. M. (1999) · Biochemical Journal · doi:10.1042/bj3400255 · Cited by 248
Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress
Michel, C. I., Holley, C. L., Scruggs, B. S., Sidhu, R., Brookheart, R. T., Listenberger, L. L., Behlke, M. A., Ory, D. S., & Schaffer, J. E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.009 · Cited by 254
Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications
Wattanapitayakul, S. K. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00114-5 · Cited by 239
Lipotoxicity in type 2 diabetic cardiomyopathy
van de Weijer, T., Schrauwen‐Hinderling, V. B., & Schrauwen, P. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr212 · Cited by 239
Stearoyl-CoA desaturase: rogue or innocent bystander?
Hodson, L., & Fielding, B. A. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.08.002 · Cited by 220
A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis
Sparagna, G. C., Hickson-Bick, D. L. M., Buja, L. M., & McMillin, J. B. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.5.h2124 · Cited by 205
Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
Scaglia, N., Chisholm, J. W., & Igal, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006812 · Cited by 205
Role of ceramide in diabetes mellitus: evidence and mechanisms
Galadari, S., Rahman, A. U., Pallichankandy, S., Galadari, A., & Thayyullathil, F. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-98 · Cited by 205
Glucose and Palmitic Acid Induce Degeneration of Myofibrils and Modulate Apoptosis in Rat Adult Cardiomyocytes
Dyntar, D., Eppenberger-Eberhardt, M., Maedler, K., Pruschy, M. N., Eppenberger, H. M., Spinas, G. A., & Donath, M. Y. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2105 · Cited by 194
Activation of Peroxisome Proliferator–Activated Receptor-&agr; Protects the Heart From Ischemia/Reperfusion Injury
Yue, T., Bao, W., Jucker, B., Gu, J. L., Romanic, A., Brown, P., Cui, J.-Q., Thudium, D., Boyce, R., Burns-Kurtis, C. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000093187.42015.6c · Cited by 157
MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1
Zhu, H., Yang, Y., Wang, Y., Li, J., Schiller, P. W., & Peng, T. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr145 · Cited by 191
Scd3—A Novel Gene of the Stearoyl-CoA Desaturase Family with Restricted Expression in Skin
Zheng, Y., Prouty, S. M., Harmon, A., Sundberg, J. P., Stenn, K. S., & Parimoo, S. (2001) · Genomics · doi:10.1006/geno.2000.6429 · Cited by 188
Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis
Busch, A. K., Gurisik, E., Cordery, D. V., Sudlow, M., Denyer, G. S., Laybutt, D. R., Hughes, W. E., & Biden, T. J. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2917 · Cited by 184
Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes
van der Lee, K. A. J. M., Vork, M. M., de Vries, J. E., Willemsen, P. H. M., Glatz, J. F. C., Reneman, R. S., Vusse, G. J., & van Bilsen, M. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32072-1 · Cited by 175
Self-citation
Docosahexaenoic Acid, a Peroxisome Proliferator–Activated Receptor-α Ligand, Induces Apoptosis in Vascular Smooth Muscle Cells by Stimulation of p38 Mitogen-Activated Protein Kinase
Diep, Q. N., Touyz, R. M., & Schiffrin, E. L. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.851 · Cited by 173
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
Pfaffenbach, K. T., Gentile, C. L., Nivala, A. M., Wang, D., Wei, Y., & Pagliassotti, M. J. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00642.2009 · Cited by 176
Palmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac Myocytes
Hickson-Bick, D. L. M., Buja, L. M., & McMillin, J. B. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1098 · Cited by 170
Essential fatty acids, lipid peroxidation and apoptosis
Das, U. N. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0085 · Cited by 169
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
Turpin, S. M., Lancaster, G. I., Darby, I., Febbraio, M. A., & Watt, M. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00095.2006 · Cited by 164
Fatty acid-mediated intracellular iron translocation: A synergistic mechanism of oxidative injury
Yao, D., Shi, W., Gou, Y., Zhou, X., Aw, T. Y., Zhou, Y., & Liu, Z. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.07.015 · Cited by 161
Peroxisome Proliferator-activated Receptor α (PPARα) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart
Finck, B. N., & Kelly, D. P. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2061 · Cited by 160
Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism
Igal, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.009 · Cited by 166
Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth
Riquelme, C. A., Magida, J. A., Harrison, B. C., Wall, C. E., Marr, T. G., Secor, S. M., & Leinwand, L. A. (2011) · Science · doi:10.1126/science.1210558 · Cited by 147
Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes
Miller, T. A., LeBrasseur, N. K., Cote, G. M., Trucillo, M. P., Pimentel, D. R., Ido, Y., Ruderman, N. B., & Sawyer, D. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.088 · Cited by 146
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells
Lai, E., Bikopoulos, G. J., Wheeler, M. B., Rozakis-Adcock, M., & Volchuk, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00478.2007 · Cited by 146
Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress
Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Müller, M., & Kersten, S. (2010) · Circulation Research · doi:10.1161/circresaha.110.217380 · Cited by 133
Palmitate Induced Mitochondrial Deoxyribonucleic Acid Damage and Apoptosis in L6 Rat Skeletal Muscle Cells
Rachek, L. I., Musiyenko, S. I., LeDoux, S. P., & Wilson, G. L. (2007) · Endocrinology · doi:10.1210/en.2006-0998 · Cited by 137
Induction of apoptotic cell death and in vivo growth inhibition of human cancer cells by a saturated branched-chain fatty acid, 13-methyltetradecanoic acid.
Yang, Z., Liu, S., Chen, X., Chen, H., Huang, M., & Zheng, J. (2000) · PubMed · Cited by 130
Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
Vinciguerra, M., Carrozzino, F., Peyrou, M., Carlone, S., Montesano, R., Benelli, R., & Foti, M. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.027 · Cited by 128
Effects of fatty acids on mitochondria: implications for cell death
Penzo, D., Tagliapietra, C., Colonna, R., Petronilli, V., & Bernardi, P. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00272-4 · Cited by 127
An allostatic control of membrane lipid composition by SREBP1
Hagen, R. M., Rodríguez‐Cuenca, S., & Vidal‐Puig, A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.004 · Cited by 126
Mechanisms of Lipoapoptosis
Listenberger, L. L., & Schaffer, J. E. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00152-4 · Cited by 123
Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPARα and PPARδ
Smeets, P. J. H., Teunissen, B. E. J., Planavila, A., den Bosch, H. D. V.-V., Willemsen, P. H. M., Vusse, G. J., & van Bilsen, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802143200 · Cited by 120
Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells
Harvey, K. A., Walker, C. L., Xu, Z., Whitley, P., Pavlina, T. M., Hise, M. E., Zaloga, G. P., & Siddiqui, R. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m010371 · Cited by 123
Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A
Kong, J. Y., & Rabkin, S. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00028-7 · Cited by 116
Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth
Harvey, K. A., Walker, C. L., Pavlina, T. M., Xu, Z., Zaloga, G. P., & Siddiqui, R. A. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.10.008 · Cited by 115
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells
Wei, Y., Wang, D., & Pagliassotti, M. J. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9461-2 · Cited by 116
High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression
Wu, K.-M., Hsu, Y., Ying, M.-C., Tsai, F., Tsai, C., Chung, J., Yang, J., Tang, C., Cheng, L.-Y., Su, P.-H., et al. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0356-5 · Cited by 113
Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease
Russo, S. B., Ross, J. S., & Cowart, L. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_19 · Cited by 113
Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice
Sunaga, H., Matsui, H., Ueno, M., Maeno, T., Iso, T., Syamsunarno, M. R. A. A., Anjo, S., Matsuzaka, T., Shimano, H., Yokoyama, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms3563 · Cited by 111
Role of ceramides in the pathogenesis of diabetes mellitus and its complications
Mandal, N. A., Grambergs, R. C., Mondal, K., Basu, S. K., Tahia, F., & Dagogo-Jack, S. E. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107734 · Cited by 112
Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS
Hickson-Bick, D. L. M., Sparagna, G. C., Buja, L. M., & McMillin, J. B. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00726.2001 · Cited by 108
Activation of PPARδ inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts
Teunissen, B. E. J., Smeets, P., Willemsen, P., de Windt, L. D., van der Vusse, G., & van Bilsen, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.026 · Cited by 119
Self-citation
Microarray Analysis of the in Vivo Effects of Hypophysectomy and Growth Hormone Treatment on Gene Expression in the Rat
Flores‐Morales, A., Ståhlberg, N., Tollet‐Egnell, P., Lundeberg, J., Malek, R. L., Quackenbush, J. F., Lee, N. H., & Norstedt, G. (2001) · Endocrinology · doi:10.1210/en.142.7.3163 · Cited by 104
Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity
Bosma, M., Dapito, D. H., Drosatos-Tampakaki, Z., Son, N. H., Huang, L., Kersten, S., Drosatos, K., & Goldberg, I. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.012 · Cited by 109
Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation
Yu, G., Luo, H., Zhang, N., Wang, Y., Li, Y., Huang, H., Liu, Y., Hu, Y., Liu, H., Zhang, J., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246268 · Cited by 102
Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis
Igal, R. A. (2011) · Cancers · doi:10.3390/cancers3022462 · Cited by 103
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
Yamamoto, T., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020996 · Cited by 107
Covalent activation of heart AMP‐activated protein kinase in response to physiological concentrations of long‐chain fatty acids
Clark, H. S., Carling, D., & Saggerson, D. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04151.x · Cited by 105
Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization
Brindley, D. N., Kok, B. P., Kienesberger, P. C., Lehner, R. S., & Dyck, J. R. B. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00509.2009 · Cited by 102
Lipotoxicity in the heart
Borradaile, N. M., & Schaffer, J. E. (2005) · Current Hypertension Reports · doi:10.1007/s11906-005-0035-y · Cited by 99
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
Planavila, A., Domínguez, E., Navarro, M., Vinciguerra, M., Iglesias, R., Giralt, M., Lope‐Piedrafita, S., Ruberte, J., & Villarroya, F. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.07.019 · Cited by 92
Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase
Kim, J.-E., Song, S. E., Kim, Y., Kim, J., Park, S., Park, Y.-K., Baek, S., Lee, I. K., & Park, S. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0093 · Cited by 90
Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis
Subedi, A., Liu, Q., Ayyathan, D. M., Sharon, D. M., Cathelin, S., Hosseini, M., Xu, C., Voisin, V., Bader, G. D., D’Alessandro, A., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2021.06.004 · Cited by 86
Mitochondrial energy dissipation by fatty acids
Bernardi, P., Penzo, D., & Wojtczak, L. (2002) · Vitamins and hormones · doi:10.1016/s0083-6729(02)65061-7 · Cited by 85
Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?
Silva‐Palacios, A., Königsberg, M., & Zazueta, C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.005 · Cited by 84
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
Rachek, L. I., Thornley, N. P., Grishko, V. I., LeDoux, S. P., & Wilson, G. L. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0865 · Cited by 81
Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus
Leonardi, O., Mints, G., & Hussain, M. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490099 · Cited by 81
Inhibition of protein kinase R protects against palmitic acid–induced inflammation, oxidative stress, and apoptosis through the JNK/NF‐kB/NLRP3 pathway in cultured H9C2 cardiomyocytes
Mangali, S., Bhat, A., Udumula, M. P., Dhar, I., Sriram, D., & Dhar, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27643 · Cited by 78
Unsaturated fatty acids and their oxidation products stimulate CD36 gene expression in human macrophages
Vallvé, J.-C., Uliaque, K., Girona, J., Cabré, A., Ribalta, J., Heras, M., & Masana, L. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00046-1 · Cited by 78
Metabolic, structural and biochemical changes in diabetes and the development of heart failure
Ho, K. L., Karwi, Q. G., Connolly, D., Pherwani, S., Ketema, E. B., Ussher, J. R., & Lopaschuk, G. D. (2022) · Diabetologia · doi:10.1007/s00125-021-05637-7 · Cited by 79
Dexamethasone-induced lipolysis increases the adverse effect of adipocytes on osteoblasts using cells derived from human mesenchymal stem cells
Wang, D., Haile, A., & Jones, L. C. (2013) · Bone · doi:10.1016/j.bone.2013.01.009 · Cited by 78
Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma
Bansal, S., Berk, M. P., Alkhouri, N., Partrick, D. A., Fung, J. J., & Feldstein, A. E. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.07.001 · Cited by 76
Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element
Zhang, L., Ge, L., Tran, T., Stenn, K. S., & Prouty, S. M. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570183 · Cited by 68
Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release
Pillon, N. J., Chan, K. L., Zhang, S., Mejdani, M., Jacobson, M. R., Ducos, A., Bilan, P. J., Niu, W., & Klip, A. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2016 · Cited by 70
Effects of fatty acids on uncoupling protein‐2 expression in the rat heart
van der Lee, K. A. J. M., Willemsen, P. H. M., Vusse, G. J., & van Bilsen, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.3.495 · Cited by 67
Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition
Beeharry, N., Chambers, J. A., & Green, I. C. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000038039.82506.0c · Cited by 67
Lipoptosis
Pohle, T., Brändlein, S., Ruoff, N., Müller‐Hermelink, H. K., & Vollmers, H. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3149 · Cited by 66
Docosahexaenoic Acid Protects Muscle Cells from Palmitate-Induced Atrophy
Bryner, R. W., Woodworth‐Hobbs, M. E., Williamson, D. L., & Alway, S. E. (2012) · ISRN Obesity · doi:10.5402/2012/647348 · Cited by 69
Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling
van Nieuwenhoven, F. A., Munts, C., Veld, R. C. O., González, A., Dı́ez, J., Heymans, S. R. B., Schroen, B. L. M., & van Bilsen, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16201-y · Cited by 64
Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats
Hasselbaink, D. M., Glatz, J. F. C., Luiken, J. J. F. P., Roemen, T. H. M., & Vusse, G. J. (2003) · Biochemical Journal · doi:10.1042/bj20021617 · Cited by 60
Self-citation
Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin
Kong, J. Y., & Rabkin, S. W. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00257.2001 · Cited by 61
Fatty acid metabolism in cardiac failure: biochemical, genetic and cellular analysis
Marín-García, J. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00552-1 · Cited by 62

Authors: de Vries, J. E., Vork, M. M., Roemen, T. H., de Jong, Y. F., Cleutjens, J. P., van der Vusse, G. J., & van Bilsen, M.
Affiliations: Maastricht University (NL)
ORCID: Cleutjens, J P
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1997-07
Volume: 38
Issue: 7
Pages: 1384-1394
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)37421-6
OpenAlex: W2407618083
Cited by: 324
References: 47
Citations by year: 2026: 2 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 7 · 2013: 21 · 2012: 16
FWCI: 6.75
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8484 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: saturated fatty acids, monounsaturated fatty acids, palmitic acid, stearic acid, cardiomyocyte apoptosis, neonatal rat ventricular myocytes, membrane damage, triglyceride accumulation, fatty acid oxidation, cardiotoxicity
MeSH terms: Fatty Acid-Binding Protein 7, Animals, Animals, Newborn, Carrier Proteins, Cells, Cultured, Culture Media, Fatty Acids, Fatty Acids, Monounsaturated, Glucose, Kinetics, L-Lactate Dehydrogenase, Myocardium, Neoplasm Proteins, Nerve Tissue Proteins, Phospholipids, Rats, Inbred WKY, Serum Albumin, Bovine, Triglycerides, Apoptosis, Myelin P2 Protein, Fatty Acid-Binding Proteins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks