Evidence from in vitro differentiating cells that adrenoceptor agonists can increase uncoupling protein mRNA level in adipocytes of adult humans: An RT-PCR study
Open accessAbstract
In vivo data have suggested that adrenergic signals can reactivate dormant brown adipocytes in adult humans. We report here a system based on primary cultures of perirenal adipocytes from human adults and reverse transcription-PCR of uncoupling protein mRNA. Norepinephrine and compounds classified as beta 3-adrenoceptor agonists in rodents increased uncoupling protein mRNA level in human adipocytes (presumably brown adipocytes). Although we did not demonstrate that the observed effect was mediated by beta 3-adrenoceptors, it is proposed that this system could be used to appreciate the ability of beta-adrenoceptor agonists to activate UCP gene transcription and help to select beta 3-adrenoceptor agonists and antagonists prior to in vivo trials; indeed, the difficulty in developing such drugs that are effective in humans may result from the fact that the screening of molecules has historically been made in rodents.
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Catecholamines such as noradrenaline activate β3 adrenergic receptors and upregulate UCP-1 expression in mouse, rat, and human brown adipose tissues.
“These molecules are also known to upregulate UCP-1 expression in many models, including mouse [40,41], rat [42,43], and human [44] brown adipose tissues.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [44]
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- Authors
- Champigny, O., & Ricquier, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 37
- Issue
- 9
- Pages
- 1907-1914
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2186023736
- Cited by
- 52
- References
- 42
- Citations by year
- 2023: 1 · 2019: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- uncoupling proteins, brown adipocytes, beta3-adrenergic agonists, norepinephrine, adrenergic signaling, human adipocytes, perirenal fat, gene transcription, drug screening, thermogenesis
- MeSH terms
- Uncoupling Protein 1, Adrenergic beta-Agonists, Adult, Adipose Tissue, Brown, Carrier Proteins, Cell Differentiation, Cells, Cultured, Humans, Hyperaldosteronism, Ion Channels, Kidney Neoplasms, Membrane Proteins, Pheochromocytoma, Receptors, Adrenergic, beta, RNA-Directed DNA Polymerase, RNA, Messenger, Stem Cells, Polymerase Chain Reaction, Adipocytes, Receptors, Adrenergic, beta-3, Mitochondrial Proteins
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