Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist
Abstract
In a previous study, we demonstrated that chronic treatment with a new beta3-adrenoceptor agonist, CL 316,243 [disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-ben zodioxazole-2,2-dicarboxylate], promoted thermogenesis, caused the appearance of multilocular adipocytes in white adipose tissue (WAT), and retarded development of obesity in young rats eating a high-fat diet (Himms-Hagen et al., Am J Physiol 266: R1371-R1382, 1994). Objectives of the present study were to find out whether CL 316,243 could reverse established diet-induced obesity in rats and to identify the multilocular adipocytes that appeared in WAT. Infusion of CL 316,243 (1 mg/kg/day) reduced abdominal fat, with a decrease in enlarged adipocyte size but no loss of white adipocytes. The resting metabolic rate increased by 40-45%, but food intake was not altered. Abundant densely stained multilocular brown adipocytes expressing uncoupling protein (UCP) appeared in retroperitoneal WAT, in which a marked increase in protein content occurred. UCP content of interscapular brown adipose tissue (BAT) was also increased markedly. We suggest that the substantial increase in the resting metabolic rate induced by CL 316,243 occurs in brown adipocytes in both BAT and WAT. The origin of the brown adipocytes that appeared in WAT is uncertain. They may have been small brown preadipocytes, expressing beta3-adrenoceptors but with few mitochondria and little or no UCP, that were induced to hypertrophy by the beta3-agonist.
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Induction of BAT in mice promotes energy expenditure, reduces adiposity, and protects mice from diet-induced obesity.
“Induction of BAT in mice promotes energy expenditure, reduces adiposity, and protects mice from diet-induced obesity 73,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [73]
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- Authors
- Ghorbani, M., Claus, T. H., & Himms-Hagen, J.
- Affiliations
- University of Ottawa (CA)
- Wyeth (US)
- ORCID
- Ghorbani, Masoud
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 54
- Issue
- 1
- Pages
- 121-131
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2041287325
- Cited by
- 195
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 9 · 2012: 11
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- CL316,243, beta3-adrenergic agonists, brown adipocytes, brown adipose tissue, white adipose tissue, diet-induced obesity, obesity reversal, adipocyte hypertrophy, uncoupling proteins, thermogenesis, resting metabolic rate, high-fat diet, retroperitoneal adipose tissue, interscapular brown adipose tissue, adipocyte origin
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Adrenergic beta-Agonists, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Dietary Fats, Dioxoles, Epididymis, Hypertrophy, Immunohistochemistry, Ion Channels, Male, Membrane Proteins, Obesity, Organ Size, Receptors, Adrenergic, beta, Retroperitoneal Space, Rats, Sprague-Dawley, Receptors, Adrenergic, beta-3, Mitochondrial Proteins, Rats
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