Cited by 278Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts. Lipid and nonlipid factors.

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Blankenhorn, D H, Alaupovic, P, Wickham, E, Chin, H P, Azen, S P·1990·Circulation

Abstract

A within-group risk factor analysis was conducted to predict angiographic change in the Cholesterol Lowering Atherosclerosis Study, a randomized, placebo-controlled trial of colestipol plus niacin therapy in men with previous coronary bypass surgery. Global angiographic change, including both native coronary arteries and bypass grafts after 2 treatment years, was the end point. Risk factors included on-trial clinical measures, plasma lipids, lipoproteins, and apolipoproteins. Univariate analysis indicated that risk factors previously observed by others in epidemiologic investigation of ischemic heart disease--total cholesterol, LDL cholesterol, non-HDL cholesterol, triglycerides, apolipoprotein B, and diastolic blood pressure--had significant effects in the placebo-treated group. Univariate analysis indicated significant effects of apolipoprotein C-III in drug- and placebo-treated groups. Multivariate analysis indicated the predominant risk factor predicting the probability of global coronary progression was non-HDL cholesterol in placebo-treated subjects and the content of apolipoprotein C-III in high density lipoproteins of drug-treated subjects. Both drug- and placebo-treated group findings point to an important role for triglyceride-rich lipoproteins in progression and regression of human atherosclerosis.

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Crossref · 10.1161/01.cir.81.2.470

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  • The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, and this relationship has now been confirmed in many studies.

    “The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, 61 and this relationship has now been confirmed in many studies. [203]3][204][205][206][207][208][209][210][211][212][213][214][215][216]”

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Authors
Blankenhorn, D. H., Alaupovic, P., Wickham, E., Chin, H. P., & Azen, S. P.
Affiliations
University of Southern California (US)
Venue
Circulation
Published
1990-02
Volume
81
Issue
2
Pages
470-476
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2092138949
Cited by
278
References
32
Citations by year
2026: 1 · 2025: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 8 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 6
FWCI
22.83
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Oklahoma Medical Research Foundation
  • National Institutes of Health (5p01hl023619-10)
  • National Heart, Lung, and Blood Institute (HL 23619)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
coronary artery disease progression, aortocoronary bypass graft, native coronary arteries, colestipol, nicotinic acid, cholesterol-lowering therapy, risk factors, non-HDL cholesterol, apolipoprotein C-III, HDL cholesterol, triglyceride-rich lipoproteins, apolipoprotein B, LDL cholesterol, triglycerides, diastolic blood pressure, atherosclerosis regression
MeSH terms
Coronary Artery Bypass, Apolipoproteins, Apolipoproteins C, Colestipol, Coronary Artery Disease, Humans, Lipids, Male, Middle Aged, Niacin, Recurrence, Multivariate Analysis, Randomized Controlled Trials as Topic, Coronary Angiography, Apolipoprotein C-III

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