Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study
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Objectives—: Patients with obesity and diabetes mellitus have increased risk of cardiovascular disease. A major cause is an atherogenic dyslipidemia related primarily to elevated plasma concentrations of triglyceride-rich lipoproteins. The aim of this study was to clarify determinants of plasma triglyceride concentration. We focused on factors that predict the kinetics of very-low density lipoprotein 1 (VLDL 1 ) triglycerides. Approach and Results—: A multicenter study using dual stable isotopes (deuterated leucine and glycerol) and multicompartmental modeling was performed to elucidate the kinetics of triglycerides and apoB in VLDL 1 in 46 subjects with abdominal obesity and additional cardiometabolic risk factors. Results showed that plasma triglyceride concentrations were dependent on both the secretion rate ( r =0.44, P <0.01; r =0.45, P <0.01) and fractional catabolism ( r =0.49, P <0.001; r =0.55, P <0.001) of VLDL 1 -triglycerides and VLDL 1 -apoB. Liver fat mass was independently and directly associated with secretion rates of VLDL 1 -triglycerides ( r =0.56, P <0.001) and VLDL 1 -apoB ( r =0.53, P <0.001). Plasma apoC-III concentration was independently and inversely associated with the fractional catabolisms of VLDL 1 -triglycerides ( r =0.48, P <0.001) and VLDL 1 -apoB ( r =0.51, P <0.001). Conclusions—: Plasma triglyceride concentrations in abdominal obesity are determined by the kinetics of VLDL 1 subspecies, catabolism being mainly dependent on apoC-III concentration and secretion on liver fat content. Reduction in liver fat and targeting apoC-III may be an effective approach for correcting triglyceride metabolism atherogenic dyslipidemia in obesity.
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Oestrogen replacement therapy has not been shown to reduce cardiovascular risk.
“Oestrogen replacement therapy, despite some favourable effects on lipid profiles, has not been demonstrated to reduce CV risk”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [392]
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- Authors
- Borén, J., Watts, G. F., Adiels, M., Söderlund, S., Chan, D. C., Hakkarainen, A., Lundbom, J., Lundbom, N., Matikainen, N., Kahri, J., Vergès, B., Barrett, P. H. R., & Taskinen, M.-R.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2015-10
- Volume
- 35
- Issue
- 10
- Pages
- 2218-2224
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2563118716
- Cited by
- 72
- References
- 55
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-11-01)
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- RUNE (Research UNE) (submittedVersion)
- Funders
- Sanofi
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Hjärt-Lungfonden
- Novo Nordisk
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Novo Nordisk Fonden (NNF14OC0010799)
- Diabetestutkimussäätiö
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- abdominal obesity, triglyceride kinetics, fractional catabolic rate, hepatic fat content, apolipoprotein C-III, atherogenic dyslipidemia, cardiometabolic risk
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Female, Humans, Kinetics, Lipoproteins, Lipoproteins, VLDL, Liver, Male, Middle Aged, Models, Biological, Organ Size, Radioactive Tracers, Reference Values, Triglycerides, Cohort Studies, Body Mass Index, Risk Assessment, Dyslipidemias, Apolipoprotein C-III, Obesity, Abdominal
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