Cited by 72Lipid metabolism and disordersDiabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular Health

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study

Open access
Borén, Jan, Watts, Gerald F., Adiels, Martin, Söderlund, Sanni, Chan, Dick C., Hakkarainen, Antti, Lundbom, Jesper, Lundbom, Nina +5 more·2015·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Objectives—: Patients with obesity and diabetes mellitus have increased risk of cardiovascular disease. A major cause is an atherogenic dyslipidemia related primarily to elevated plasma concentrations of triglyceride-rich lipoproteins. The aim of this study was to clarify determinants of plasma triglyceride concentration. We focused on factors that predict the kinetics of very-low density lipoprotein 1 (VLDL 1 ) triglycerides. Approach and Results—: A multicenter study using dual stable isotopes (deuterated leucine and glycerol) and multicompartmental modeling was performed to elucidate the kinetics of triglycerides and apoB in VLDL 1 in 46 subjects with abdominal obesity and additional cardiometabolic risk factors. Results showed that plasma triglyceride concentrations were dependent on both the secretion rate ( r =0.44, P <0.01; r =0.45, P <0.01) and fractional catabolism ( r =0.49, P <0.001; r =0.55, P <0.001) of VLDL 1 -triglycerides and VLDL 1 -apoB. Liver fat mass was independently and directly associated with secretion rates of VLDL 1 -triglycerides ( r =0.56, P <0.001) and VLDL 1 -apoB ( r =0.53, P <0.001). Plasma apoC-III concentration was independently and inversely associated with the fractional catabolisms of VLDL 1 -triglycerides ( r =0.48, P <0.001) and VLDL 1 -apoB ( r =0.51, P <0.001). Conclusions—: Plasma triglyceride concentrations in abdominal obesity are determined by the kinetics of VLDL 1 subspecies, catabolism being mainly dependent on apoC-III concentration and secretion on liver fat content. Reduction in liver fat and targeting apoC-III may be an effective approach for correcting triglyceride metabolism atherogenic dyslipidemia in obesity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/atvbaha.115.305614

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Borén, J., Watts, G. F., Adiels, M., Söderlund, S., Chan, D. C., Hakkarainen, A., Lundbom, J., Lundbom, N., Matikainen, N., Kahri, J., Vergès, B., Barrett, P. H. R., & Taskinen, M.-R.
Affiliations
University of Helsinki (FI)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2015-10
Volume
35
Issue
10
Pages
2218-2224
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2563118716
Cited by
72
References
55
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 3
FWCI
5.58
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
  • Chalmers Research (Chalmers University of Technology) (submittedVersion)
  • RUNE (Research UNE) (submittedVersion)
Funders
  • Sanofi
  • Helsingin ja Uudenmaan Sairaanhoitopiiri
  • Hjärt-Lungfonden
  • Novo Nordisk
  • Vetenskapsrådet
  • Sahlgrenska Universitetssjukhuset
  • Novo Nordisk Fonden (NNF14OC0010799)
  • Diabetestutkimussäätiö
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
abdominal obesity, triglyceride kinetics, fractional catabolic rate, hepatic fat content, apolipoprotein C-III, atherogenic dyslipidemia, cardiometabolic risk
MeSH terms
Adipose Tissue, Cardiovascular Diseases, Female, Humans, Kinetics, Lipoproteins, Lipoproteins, VLDL, Liver, Male, Middle Aged, Models, Biological, Organ Size, Radioactive Tracers, Reference Values, Triglycerides, Cohort Studies, Body Mass Index, Risk Assessment, Dyslipidemias, Apolipoprotein C-III, Obesity, Abdominal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review