The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations.
Open accessAbstract
ApoE phenotypes were determined in 615 unrelated Finnish individuals. The apoE gene frequencies observed (epsilon 2, 0.041; epsilon 3, 0.733; epsilon 4, 0.227) differ significantly from those in other populations. The frequency of the allele epsilon 2 was lower and that of epsilon 4 higher than in all other studied populations. Plasma lipids and apolipoproteins A-I, A-II and B were recorded in 207 of the typed subjects. By comparison with the most frequent homozygous apoE 3/3 phenotype, it was found that total cholesterol, LDL-cholesterol, and apoB concentrations were all markedly higher in apoE 4/4 and to a lesser degree in apoE 4/3 phenotypic groups. On the other hand, these lipid and apolipoprotein levels tended to be lower in E-2 heterozygotes. These data confirm and extend, in a different ethnic group, previous results of an effect of apoE genes on plasma lipoprotein concentrations. The data suggest that the apoE gene locus may be one factor responsible for the high LDL cholesterol concentrations in the Finnish population.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Self-citationZannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
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Polymorphism of apolipoprotein E: Genetics of hyperlipoproteinemia type III
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Cited by
Association of apolipoprotein E genotypes with lipid levels and coronary risk
Bennet, A. M., Di Angelantonio, E., Ye, Z., Wensley, F., Dahlin, A., Ahlbom, A., Keavney, B., Collins, R., Wiman, B., de Faire, U., et al. (2007) · JAMA · doi:10.1001/jama.298.11.1300 · Cited by 794
Alzheimer’s disease: the cholesterol connection
Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 677
Predictors of cognitive decline and mortality of aged people over a 10‐year period
Tilvis, R. S., Kahonen-Vare, M. H., Jolkkonen, J., Valvanne, J., Pitkala, K. H., & Strandberg, T. E. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m268 · Cited by 578
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study
Wilson, P. W. F. (1994) · JAMA · doi:10.1001/jama.1994.03520210050031 · Cited by 468
Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis.
Dallongeville, J., Lussier-Cacan, S., & Davignon, J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41611-6 · Cited by 448
Metadata
- Authors
- Ehnholm, C., Lukka, M., Kuusi, T., Nikkilä, E., & Utermann, G.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 27
- Issue
- 3
- Pages
- 227-235
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2188938709
- Cited by
- 405
- References
- 53
- FWCI
- 34.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ehnholm, C., Lukka, M., Kuusi, T., Nikkilä, E., & Utermann, G. (1987). Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)38833-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
