Staying in Touch: The Molecular Era of Organelle Contact Sites

Elbaz, Yael; Schuldiner, Maya

doi:10.1016/j.tibs.2011.08.004

Cited by 226Cellular transport and secretionIon Channels and ReceptorsAutophagy in Disease and Therapy

Staying in Touch: The Molecular Era of Organelle Contact Sites

Elbaz, Yael, Schuldiner, Maya·2011·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2011.08.004

Open this paper in CoChat — free account

Abstract

Membrane contact sites (MCS) are close appositions between two organelles that facilitate both signaling and the passage of ions and lipids from one cellular compartment to another. Despite the fact that MCS have been observed for over 50 years now, we still know very little about the molecular machinery required to create them or their structure, function and regulation. In this review, we focus on the three best-characterized contact sites to date: the nucleus-vacuole junction and mitochondria-ER and plasma membrane-ER contact sites. In addition, we discuss principles arising from recent research and highlight several unanswered questions in the field.

Integrity signals

Registry

Crossref · 10.1016/j.tibs.2011.08.004

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Different organelles are in physical contact with each other and exchange substances and information through their contact sites.
“It has become clear that different organelles are in physical contact with each other and exchange substances and information through their contact sites [19,20].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [19]

A model for receptor-regulated calcium entry
Putney, J. W. (1986) · Cell Calcium · doi:10.1016/0143-4160(86)90026-6 · Cited by 2,575 · see citing works
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442 · see citing works
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.-H., Tanasă, B., Hogan, P. G., Lewis, R. S., Daly, M. J., & Rao, A. (2006) · Nature · doi:10.1038/nature04702 · Cited by 2,278 · see citing works
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
Liou, J., Kim, M. L., Heo, W. D., Jones, J. T., Myers, J. W., Ferrell, J. E., & Meyer, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.055 · Cited by 2,126 · see citing works
STIM1, an essential and conserved component of store-operated Ca2 + channel function
Roos, J., DiGregorio, P. J., Yeromin, A. V., Ohlsen, K. L., Lioudyno, M., Zhang, S., Safrina, O., Kozak, J. A., Wagner, S. L., Cahalan, M. D., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502019 · Cited by 1,819 · see citing works
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
Szabadkai, G., Bianchi, K., Várnai, P., De Stefani, D., Wieckowski, M. R., Cavagna, D., Nagy, A. I., Balla, T., & Rizzuto, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200608073 · Cited by 1,413 · see citing works
Molecular biology of steroid hormone synthesis
MILLER, W. L. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-3-295 · Cited by 1,397 · see citing works
Structural and functional features and significance of the physical linkage between ER and mitochondria
Csordás, G., Renken, C. W., Várnai, P., Walter, L., Weaver, D., BUTTLE, K. F., Balla, T., Mannella, C. A., & Hajnóczky, G. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604016 · Cited by 1,377 · see citing works
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan‐Huberson, M., Kraft, S., Turner, H. C., Fleig, A., Penner, R., et al. (2006) · Science · doi:10.1126/science.1127883 · Cited by 1,322 · see citing works
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science · doi:10.1126/science.1175088 · Cited by 1,275 · see citing works
Self-citation
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,201 · see citing works
Phospholipid synthesis in a membrane fraction associated with mitochondria.
Vance, J. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39106-9 · Cited by 1,153 · see citing works
Control of mitochondrial morphology by a human mitofusin
Santel, A., & Fuller, M. T. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.5.867 · Cited by 1,012 · see citing works
Genome-wide RNAi screen of Ca 2+ influx identifies genes that regulate Ca 2+ release-activated Ca 2+ channel activity
Zhang, S. L., Yeromin, A. V., Zhang, X. H.-F., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman, K. A., & Cahalan, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603161103 · Cited by 863 · see citing works
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
Wu, M. M., Buchanan, J., Luik, R. M., & Lewis, R. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604014 · Cited by 789 · see citing works
MAM: more than just a housekeeper
Hayashi, T., Rizzuto, R., Hajnoczky, G., & Su, T.-P. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.12.002 · Cited by 787 · see citing works
Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
Jonikas, M. C., Collins, S. R., Denic, V., Oh, E., Toyama, E. Q., Schmid, V., Weibezahn, J., Schwappach, B., Walter, P., Weissman, J. S., et al. (2009) · Science · doi:10.1126/science.1167983 · Cited by 713 · see citing works
Self-citation
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Glued and late endosome positioning
Rocha, N., Kuijl, C. P., van der Kant, R., Janssen, L., Houben, D., Janssen, H., Zwart, W. T., & Neefjes, J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811005 · Cited by 705 · see citing works
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
Luik, R. M., Wu, M. M., Buchanan, J., & Lewis, R. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604015 · Cited by 639 · see citing works
PACS‐2 controls endoplasmic reticulum–mitochondria communication and Bid‐mediated apoptosis
Simmen, T., Aslan, J. E., Blagoveshchenskaya, A. D., Thomas, L., Wan, L., Xiang, Y. K., Feliciangeli, S. F., Hung, C., Crump, C. M., & Thomas, G. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600559 · Cited by 593 · see citing works
JunctophilinsA Novel Family of Junctional Membrane Complex Proteins
Takeshima, H. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00003-4 · Cited by 584 · see citing works
Making heads or tails of phospholipids in mitochondria
Osman, C., Voelker, D. R., & Langer, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201006159 · Cited by 580 · see citing works
Structural organization of the endoplasmic reticulum
Voeltz, G. K., Rolls, M. M., & Rapoport, T. A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf202 · Cited by 552 · see citing works
Fis1 and Bap31 bridge the mitochondria–ER interface to establish a platform for apoptosis induction
Iwasawa, R., Mahul‐Mellier, A., Datler, C., Pazarentzos, E., & Grimm, S. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.346 · Cited by 520 · see citing works
Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites
Stefan, C. J., Manford, A. G., Baird, D., Yamada-Hanff, J., Mao, Y., & Emr, S. D. (2011) · Cell · doi:10.1016/j.cell.2010.12.034 · Cited by 499 · see citing works
The plant ER: a dynamic organelle composed of a large number of discrete functional domains
Staehelin, L. A. (1997) · The Plant Journal · doi:10.1046/j.1365-313x.1997.11061151.x · Cited by 465 · see citing works
Piecemeal Microautophagy of Nucleus in Saccharomyces cerevisiae
Roberts, P., Moshitch-Moshkovitz, S., Kvam, E., O'Toole, E. T., Winey, M., & Goldfarb, D. S. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0483 · Cited by 434 · see citing works
Structural mechanism for sterol sensing and transport by OSBP-related proteins
Im, Y. J., Raychaudhuri, S., Prinz, W. A., & Hurley, J. H. (2005) · Nature · doi:10.1038/nature03923 · Cited by 422 · see citing works
Structure and Development of E-C Coupling Units in Skeletal Muscle
Franzini‐Armstrong, C., & Jorgensen, A. O. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.002453 · Cited by 414 · see citing works
A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature
West, M., Zurek, N. A., Hoenger, A., & Voeltz, G. K. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011039 · Cited by 396 · see citing works
Structural and functional link between the mitochondrial network and the endoplasmic reticulum
Giorgi, C., Stefani, D. D., Bononi, A., Rizzuto, R., & Pinton, P. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.04.010 · Cited by 375 · see citing works
An intimate collaboration between peroxisomes and lipid bodies
Binns, D. D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C. J., Chapman, K. D., Anderson, R. G. W., & Goodman, J. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511125 · Cited by 367 · see citing works
Nucleus–Vacuole Junctions inSaccharomyces cerevisiaeAre Formed Through the Direct Interaction of Vac8p with Nvj1p
Pan, X., Roberts, P., Chen, Y., et al. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2445 · Cited by 336 · see citing works
The Conserved GTPase Gem1 Regulates Endoplasmic Reticulum–Mitochondria Connections
Kornmann, B., Osman, C., & Walter, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111314108 · Cited by 335 · see citing works
Calcium-Induced Calcium Release in Skeletal Muscle
Endo, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00040.2008 · Cited by 335 · see citing works
The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Ca V 1.2 Channels
Wang, Y., Deng, X., Mancarella, S., Hendron, E., Eguchi, S., Soboloff, J., Tang, X. D., & Gill, D. L. (2010) · Science · doi:10.1126/science.1191086 · Cited by 334 · see citing works
The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels
Park, C. Y., Shcheglovitov, A., & Dolmetsch, R. E. (2010) · Science · doi:10.1126/science.1191027 · Cited by 321 · see citing works
A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking
Du, X., Kumar, J. K., Ferguson, C., Schulz, T. A., Ong, Y. S., Hong, W., Prinz, W. A., Parton, R. G., Brown, A. J., & Yang, H. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201004142 · Cited by 309 · see citing works
Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.
Urbani, L. J., & Simoni, R. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39918-1 · Cited by 305 · see citing works
Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact
Achleitner, G., Gaigg, B., Krasser, A., Kainersdorfer, E., Kohlwein, S. D., Perktold, A., Zellnig, G., & Daum, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00658.x · Cited by 300 · see citing works
An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship
de Brito, O. M., & Scorrano, L. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.177 · Cited by 297 · see citing works
Presenilin 2 modulates endoplasmic reticulum (ER)–mitochondria interactions and Ca 2+ cross-talk
Zampese, E., Fasolato, C., Kipanyula, M. J., Bortolozzi, M., Pozzan, T., & Pizzo, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100735108 · Cited by 285 · see citing works
Import of lipids into mitochondria
Daum, G., & Vance, J. E. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00006-4 · Cited by 283 · see citing works
The Mitochondrial Morphology Protein Mdm10 Functions in Assembly of the Preprotein Translocase of the Outer Membrane
Meisinger, C., Rissler, M., Chacińska, A., Szklarz, L. K. S., Milenkovic, D., Kozjak‐Pavlovic, V., Schönfisch, B., Lohaus, C., Meyer, H. E., Yaffe, M. P., et al. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.003 · Cited by 268 · see citing works
An Association between Mitochondria and the Endoplasmic Reticulum in Cells of the Pseudobranch Gland of a Teleost
Copeland, D. E., & Dalton, A. J. (1959) · The Journal of Cell Biology · doi:10.1083/jcb.5.3.393 · Cited by 261 · see citing works
A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids
Pichler, H., Gaigg, B., Hrastnik, C., Achleitner, G., Kohlwein, S. D., Zellnig, G., Perktold, A., & Daum, G. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02116.x · Cited by 259 · see citing works
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein–related proteins and phosphoinositides
Raychaudhuri, S., Im, Y. J., Hurley, J. H., & Prinz, W. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510084 · Cited by 255 · see citing works
The Diverse Functions of Oxysterol-Binding Proteins
Raychaudhuri, S., & Prinz, W. A. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113334 · Cited by 248 · see citing works
Transport of Newly Synthesized Sterol to the Sterol-Enriched Plasma Membrane Occurs via Nonvesicular Equilibration
Baumann, N. A., Sullivan, D. P., Ohvo-Rekilä, H., et al. (2005) · Biochemistry · doi:10.1021/bi048296z · Cited by 234 · see citing works
Tsc13p Is Required for Fatty Acid Elongation and Localizes to a Novel Structure at the Nuclear-Vacuolar Interface in Saccharomyces cerevisiae
Kohlwein, S. D., Eder, S., Oh, C., Martin, C. E., Gable, K., Bačíková, D., & Dunn, T. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.109-125.2001 · Cited by 228 · see citing works
Similarity of junctions between plasma membranes and endoplasmic reticulum in muscle and neurons.
Henkart, M. P., Landis, D. M. D., & Reese, T. S. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.70.2.338 · Cited by 224 · see citing works
Intracellular sites of lipid synthesis and the biogenesis of mitochondria
Dennis, E. A., & Kennedy, E. P. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39421-9 · Cited by 218 · see citing works
Piecemeal Microautophagy of the Nucleus Requires the Core Macroautophagy Genes
Krick, R., Mühe, Y., Prick, T., Bremer, S., Schlotterhose, P., Eskelinen, E., Millen, J. I., Goldfarb, D. S., & Thumm, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-04-0363 · Cited by 212 · see citing works
Homology of SMP Domains to the TULIP Superfamily of Lipid-Binding Proteins Provides a Structural Basis for Lipid Exchange between ER and Mitochondria
Kopec, K. O., Alva, V., & Lupas, A. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq326 · Cited by 212 · see citing works
Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
Levine, T. P. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.017 · Cited by 208 · see citing works
ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology
Kornmann, B., & Walter, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.058636 · Cited by 205 · see citing works
Dual Targeting of Osh1p, a Yeast Homologue of Oxysterol-binding Protein, to both the Golgi and the Nucleus-Vacuole Junction
Levine, T. P., & Munro, S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.6.1633 · Cited by 202 · see citing works
Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria
Gaigg, B., Simbeni, R., Hrastnik, C., Paltauf, F., & Daum, G. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)00287-y · Cited by 200 · see citing works
Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
Lebiedzińska, M., Szabadkai, G., Jones, A. W. E., Duszyński, J., & Wieckowski, M. R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.02.017 · Cited by 197 · see citing works
Phosphatidylserine functions as the major precursor of phosphatidylethanolamine in cultured BHK-21 cells.
Voelker, D. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2669 · Cited by 187 · see citing works
Connections between mitochondria and endoplasmic reticulum in rat liver and onion stem
Morr�, D. J., Merritt, W. D., & Lembi, C. A. (1971) · PROTOPLASMA · doi:10.1007/bf01286410 · Cited by 164 · see citing works
Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p inSaccharomyces cerevisiae
Kvam, E., & Goldfarb, D. S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01372 · Cited by 140 · see citing works
Structural analysis of muscle development: Transverse tubules, sarcoplasmic reticulum, and the triad
Flucher, B. E. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90065-o · Cited by 138 · see citing works
Trichoplein/mitostatin regulates endoplasmic reticulum–mitochondria juxtaposition
Cerqua, C., Anesti, V., Pyakurel, A., Liu, D., Naón, D., Wiche, G., Baffa, R., Dimmer, K. S., & Scorrano, L. (2010) · EMBO Reports · doi:10.1038/embor.2010.151 · Cited by 129 · see citing works
Osh Proteins Regulate Membrane Sterol Organization but Are Not Required for Sterol Movement Between the ER and PM
Georgiev, A. G., Sullivan, D. P., Kersting, M. C., Dittman, J. S., Beh, C. T., & Menon, A. K. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01234.x · Cited by 125 · see citing works
Stable Golgi-Mitochondria Complexes and Formation of Golgi Ca2+ Gradients in Pancreatic Acinar Cells
Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H., & Tepikin, A. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412694200 · Cited by 108 · see citing works
Non-vesicular sterol transport in cells
Prinz, W. A. (2007) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.06.002 · Cited by 98 · see citing works
Molecular evolution of the junctophilin gene family
Garbino, A., van Oort, R. J., Dixit, S. S., Landstrom, A. P., Ackerman, M. J., & Wehrens, X. H. T. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00017.2009 · Cited by 86 · see citing works
YEB3/VAC8 encodes a myristylated armadillo protein of the Saccharomyces cerevisiae vacuolar membrane that functions in vacuole fusion and inheritance
Pan, X., & Goldfarb, D. S. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.15.2137 · Cited by 81 · see citing works
Targeting of Tsc13p to Nucleus–Vacuole Junctions: A Role for Very-Long-Chain Fatty Acids in the Biogenesis of Microautophagic Vesicles
Kvam, E., Gable, K. S., Dunn, T. M., & Goldfarb, D. S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-04-0290 · Cited by 80 · see citing works
Microautophagy of the Nucleus Coincides with a Vacuolar Diffusion Barrier at Nuclear–Vacuolar Junctions
Dawaliby, R., & Mayer, A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-09-0782 · Cited by 78 · see citing works
Nuclear pore absence from areas of close association between nucleus and vacuole in synchronous yeast cultures
Severs, N. J., Jordan, E. G., & Williamson, D. H. (1976) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(76)80023-8 · Cited by 55 · see citing works
Measuring piecemeal microautophagy of the nucleus inSaccharomyces cerevisiae
Millen, J. I., Krick, R., Prick, T., Thumm, M., & Goldfarb, D. S. (2009) · Autophagy · doi:10.4161/auto.5.1.7181 · Cited by 43 · see citing works
Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae
Rosenberger, S. F., Connerth, M., Zellnig, G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.015 · Cited by 37 · see citing works
New molecular components supporting ryanodine receptor-mediated Ca2+ release: Roles of junctophilin and TRIC channel in embryonic cardiomyocytes
Yamazaki, D., Yamazaki, T., & Takeshima, H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.11.004 · Cited by 27 · see citing works

Flagged first, then by citations

Sorted by citations

Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018 · see citing works
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Shai, N., Yifrach, E., van Roermund, C. W. T., Cohen, N., Bibi, C., IJlst, L., Cavellini, L., Meurisse, J., Schuster, R., Zada, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03957-8 · Cited by 320 · see citing works
Self-citation
A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria
Lahiri, S., Chao, J. T., Tavassoli, S., Wong, A. K. O., Choudhary, V., Young, B. P., Loewen, C. J. R., & Prinz, W. A. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001969 · Cited by 306 · see citing works
In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility
Okamoto, M., Nakano, K., Takahashi-Nakaguchi, A., Sasamoto, K., Yamaguchi, M., Teixeira, M. C., & Chibana, H. (2023) · Journal of Fungi · doi:10.3390/jof9020240 · Cited by 11 · see citing works
“It has become clear that different organelles are in physical contact with each other and exchange substances and information through their contact sites [19,20].”
Background

Authors: Elbaz, Y., & Schuldiner, M.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Schuldiner, Maya
ORCID: Schuldiner, Maya
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2011-11
Volume: 36
Issue: 11
Pages: 616-623
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2011.08.004
OpenAlex: W2128484647
Cited by: 226
References: 75
Citations by year: 2026: 6 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 17 · 2020: 14 · 2019: 15 · 2018: 9 · 2017: 21 · 2016: 16 · 2015: 31 · 2014: 25 · 2013: 21 · 2012: 10
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: membrane contact sites, nucleus-vacuole junction, lipid transfer, ion transfer
MeSH terms: Animals, Binding Sites, Cell Membrane, Cell Nucleus, Endoplasmic Reticulum, Humans, Mitochondria, Vacuoles, Organelles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Staying in Touch: The Molecular Era of Organelle Contact Sites

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks