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Cited by 933Cellular transport and secretionIon Channels and ReceptorsAutophagy in Disease and Therapy

Structure and function of ER membrane contact sites with other organelles

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Phillips, Melissa J., Voeltz, Gia K.·2016·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm.2015.8PMC PMC5117888
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Abstract

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have been studied for decades. The past several years have provided novel insights into the existence of distinct domains between the ER and other organelles, known as membrane contact sites (MCSs). At these contact sites, organelle membranes are closely apposed and tethered, but do not fuse. Here, various protein complexes can work in concert to perform specialized functions such as binding, sensing and transferring molecules, as well as engaging in organelle biogenesis and dynamics. This Review describes the structure and functions of MCSs, primarily focusing on contacts of the ER with mitochondria and endosomes.

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  • MAM participate in lipid synthesis, membrane stability, mitochondrial dynamics, and ROS signaling.

    “Besides controlling Ca2+ flux, MAM participate in lipid synthesis, membrane stability, mitochondrial dynamics, and ROS signaling [99–101].”

    From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [100]

    The ER–mitochondria section on lipid biosynthesis and exchange describes phospholipid synthesis and transfer at the contact interface; the Organelle biogenesis > ER–mitochondria section says contact sites help position mitochondrial fission. The passages located do not establish a role in membrane stability or ROS signaling. The discussion of stability in “MCS-bound organelles in motion” concerns the stability of contact sites, not membranes; page numbers are unavailable in our copy. (LLM, conf=0.86)

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Authors
Phillips, M. J., & Voeltz, G. K.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Voeltz, Gia K.
ORCID
Voeltz, Gia K.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2015-12-02
Volume
17
Issue
2
Pages
69-82
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm.2015.8
PMC
PMC5117888
OpenAlex
W2182369134
Cited by
933
References
8
Citations by year
2026: 51 · 2025: 78 · 2024: 100 · 2023: 81 · 2022: 98 · 2021: 107 · 2020: 100 · 2019: 86 · 2018: 97 · 2017: 93 · 2016: 40 · 2015: 2
FWCI
7.80
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Cancer Society
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM083977, T32GM008759, GM083977)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
membrane contact sites, endoplasmic reticulum, ER-mitochondria contact sites, organelle tethering, lipid transfer, calcium signaling, organelle biogenesis, organelle dynamics, protein complexes
MeSH terms
Animals, Organelle Biogenesis, Biological Transport, Calcium, Cell Membrane, Endoplasmic Reticulum, Eukaryotic Cells, Gene Expression Regulation, Humans, Membrane Proteins, Mitochondria, Endosomes, Saccharomyces cerevisiae, Lipid Metabolism, Mitochondrial Membranes

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