At the right distance: ER-mitochondria juxtaposition in cell life and death
Open accessAbstract
The interface between mitochondria and the endoplasmic reticulum is emerging as a crucial hub for calcium signalling, apoptosis, autophagy and lipid biosynthesis, with far reaching implications in cell life and death and in the regulation of mitochondrial and endoplasmic reticulum function. Here we review our current knowledge on the structural and functional aspects of this interorganellar juxtaposition. This article is part of a Special Issue entitled: Calcium Signaling In Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.
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Increased expression of MAM proteins enhances tethering between the organelles and modulates connectivity/conductivity.
“Increased expression of MAM proteins enhances tethering between the organelles and modulates connectivity/conductivity [102].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [102]
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- Authors
- Naon, D., & Scorrano, L.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Scorrano, Luca
- ORCID
- Scorrano, Luca
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 1843
- Issue
- 10
- Pages
- 2184-2194
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2050702202
- Cited by
- 178
- References
- 18
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 12 · 2023: 11 · 2022: 10 · 2021: 14 · 2020: 19 · 2019: 14 · 2018: 10 · 2017: 20 · 2016: 27 · 2015: 23 · 2014: 6
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- endoplasmic reticulum, mitochondria, calcium signaling, apoptosis, autophagy, lipogenesis, cell death
- MeSH terms
- Animals, Autophagy, Cell Compartmentation, Cell Survival, Endoplasmic Reticulum, Eukaryotic Cells, Humans, Intracellular Membranes, Lipids, Mitochondria, Gene Expression, Apoptosis, Calcium Signaling, Mitochondrial Membrane Transport Proteins
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