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Cited by 50Muscle metabolism and nutritionLipid metabolism and biosynthesisCardiovascular and exercise physiology

Kinetic analysis of the oxidation of palmitate-1-14C in man during prolonged heavy muscular exercise

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Havel, Richard J., Ekelund, Lars-Göran, Holmgren, Alf·1967·Journal of Lipid Research
DOI 10.1016/s0022-2275(20)39568-7
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Abstract

Two healthy men with high working capacities were injected intravenously with palmitate-1-(14)C and NaH(14)CO(3) on two occasions while they were performing strenuous exercise on a bicycle ergometer. From analysis of (14)CO(2) in expired air after injection of NaH(14)CO(3), rate constants and compartment sizes describing a three-compartment system for CO(2) were determined algebraically. These data were combined with those of a separate study in which (14)C in free fatty acids of arterial blood plasma and in expired CO(2) were measured after injection of palmitate-1-(14)C to construct an eight-compartment model with an analogue computer that described precisely the observed data in each subject. The results indicate that under these conditions almost half of the free fatty acids leaving the blood are oxidized directly (i.e., are transferred to mitochondrial oxidative sites through small intermediate compartments). The remainder enters larger compartments apart from the direct pathway; most of this fraction reenters the direct oxidative pathway within 30 min. These observations suggest that certain esterified fatty acids contained in working muscle cells are rapidly renewed. Recycling of (14)C in plasma free fatty acids and triglyceride fatty acids was substantially reduced during exercise. Values for turnover rate and extent of oxidation of free fatty acids obtained by the method of continuous intravenous infusion of palmitate-1-(14)C were similar during exercise in these two subjects to those obtained after pulse injection.

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Crossref · 10.1016/s0022-2275(20)39568-7

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  • Early studies showed that the rate of lipolysis is a key determinant of free fatty acid uptake and oxidation in skeletal muscle and documented a linear relationship between plasma long-chain fatty acid concentration and their rate of uptake and oxidation in muscle.

    “Indeed, early studies demonstrated the rate of lipolysis was a key determinant of FFA uptake and oxidation in skeletal muscle and documented a linear relationship between the plasma LCFA concentration and their rate of uptake and oxidation in the muscle [85–87].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [87]

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Authors
Havel, R. J., Ekelund, L.-G., & Holmgren, A.
Affiliations
Karolinska Institutet (SE)
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1967-07
Volume
8
Issue
4
Pages
366-373
ISSN
0022-2275 (ISSN-L)
DOI
10.1016/s0022-2275(20)39568-7
OpenAlex
W1896506440
Cited by
50
References
15
Citations by year
2024: 1
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
palmitate oxidation, free fatty acids, fatty acid turnover, compartmental model, fatty acid recycling, esterified fatty acids, triglyceride fatty acids, mitochondrial fatty acid oxidation, expired CO2
MeSH terms
Adult, Carbon Dioxide, Carbon Isotopes, Physical Exertion, Fatty Acids, Humans, Injections, Intravenous, Kinetics, Male, Models, Theoretical, Muscles, Oxidation-Reduction, Palmitic Acids

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