Cited by 40Muscle metabolism and nutritionAdipose Tissue and MetabolismCardiovascular and exercise physiology

Factors regulating fat oxidation in human skeletal muscle

Kiens, B., Alsted, T. J., Jeppesen, J.·2011·Obesity Reviews

Abstract

Summary: In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

Integrity signals

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Crossref · 10.1111/j.1467-789x.2011.00898.x

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69 of 69 references verified0 citation errors · 0 not checkable

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  • Exercise and nutrition affect the supply and demand aspects of metabolism and have been shown to influence intramyocellular lipid levels in aging and obesity.

    “they affect the supply and demand aspects of metabolism, respectively, and have been shown to influence IMCL levels in both aging and obesity [59, 97, 99, 101, 102].”

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Authors
Kiens, B., Alsted, T. J., & Jeppesen, J.
Affiliations
University of Copenhagen (DK)
Corresponding author
Kiens, B.
Venue
Obesity Reviews
Publisher
Wiley
Published
2011-09-22
Volume
12
Issue
10
Pages
852-858
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
OpenAlex
W1813900177
Cited by
40
References
69
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 3
FWCI
0.16
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
fat oxidation, skeletal muscle, lipid metabolism, physical activity, dietary fat, obesity, insulin sensitivity, lipid accumulation, plasma lipids, metabolic stress
MeSH terms
Diet, Fatty Acids, Glycogen, Humans, Mitochondria, Oxidation-Reduction, Exercise, Muscle, Skeletal, Lipid Metabolism

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