Factors regulating fat oxidation in human skeletal muscle
Abstract
Summary: In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.
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Exercise and nutrition affect the supply and demand aspects of metabolism and have been shown to influence intramyocellular lipid levels in aging and obesity.
“they affect the supply and demand aspects of metabolism, respectively, and have been shown to influence IMCL levels in both aging and obesity [59, 97, 99, 101, 102].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [101]
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Targeting Intramyocellular Lipids to Improve Aging Muscle Function
Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works
“The effectiveness of these approaches is in line with the preceding discussion of metabolic flexibility, as they affect the supply and demand aspects of metabolism, respectively, and have been shown to influence IMCL levels in both aging and obesity [59, 97, 99, 101, 102].”
- Authors
- Kiens, B., Alsted, T. J., & Jeppesen, J.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Kiens, B.
- ORCID
- Kiens, B.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2011-09-22
- Volume
- 12
- Issue
- 10
- Pages
- 852-858
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1813900177
- Cited by
- 40
- References
- 69
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 3
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- fat oxidation, skeletal muscle, lipid metabolism, physical activity, dietary fat, obesity, insulin sensitivity, lipid accumulation, plasma lipids, metabolic stress
- MeSH terms
- Diet, Fatty Acids, Glycogen, Humans, Mitochondria, Oxidation-Reduction, Exercise, Muscle, Skeletal, Lipid Metabolism
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