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Cited by 138Muscle metabolism and nutritionCardiovascular and exercise physiologyAdipose Tissue and Metabolism

Human Forearm Muscle Metabolism during Exercise II Uptake, release and oxidation of individual FFA and glycerol

Hagenfeldt, L., Wahren, J.·1968·Scandinavian Journal of Clinical and Laboratory Investigation
DOI 10.3109/00365516809076994
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Abstract

The uptake, release, and oxidation of individual free fatty acids (FFA) in the human forearm were studied during a 60-min exercise period. Muscular uptake of FFA rose with the arterial concentration. The muscle showed a slight preference for linoleic and oleic acid compared to palmitic acid. The forearm RQ indicated a constant fat oxidation during the period of exercise. The uptake of FFA covered about 50 per cent of the fat oxidation. On the average 60 per cent of the muscular FFA-14C uptake was oxidized to 14CO2. The remaining radioactivity left the muscle as water-soluble metabolite(s). β-Hydroxybutyrate leaving the muscle was shown to be labeled. No release of glycerol accompanied the release of FFA during exercise. Glycerol-1-14C was oxidized by the exercising muscle. Glycerol dehydrogenase activity was demonstrated in human skeletal muscle.

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Crossref · 10.3109/00365516809076994

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32 of 32 references verified0 citation errors · 0 not checkable

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  • Early studies showed that the rate of lipolysis is a key determinant of free fatty acid uptake and oxidation in skeletal muscle and documented a linear relationship between plasma long-chain fatty acid concentration and their rate of uptake and oxidation in muscle.

    “Indeed, early studies demonstrated the rate of lipolysis was a key determinant of FFA uptake and oxidation in skeletal muscle and documented a linear relationship between the plasma LCFA concentration and their rate of uptake and oxidation in the muscle [85–87].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [86]

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Related

Authors
Hagenfeldt, L., & Wahren, J.
Affiliations
Karolinska Institutet (SE)
ORCID
Wahren, J.
Venue
Scandinavian Journal of Clinical and Laboratory Investigation
Publisher
Informa UK Limited
Published
1968-01
Volume
21
Issue
3
Pages
263-276
ISSN
  • 0036-5513 (ISSN-L)
  • 1502-7686
DOI
10.3109/00365516809076994
OpenAlex
W2059186446
Cited by
138
References
32
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2020: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2012: 3
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National University of Singapore
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
free fatty acid uptake, fatty acid oxidation, glycerol oxidation, skeletal muscle metabolism, physical activity, forearm muscles, respiratory quotient, linoleic acid, oleic acid, palmitic acid, beta-hydroxybutyrate, glycerol dehydrogenase, fatty acid release
MeSH terms
Adult, Alcohol Oxidoreductases, Arm, Arteries, Carbon Dioxide, Carbon Isotopes, Catheterization, Chromatography, Gas, Physical Exertion, Fatty Acids, Nonesterified, Glycerol, Humans, Hydroxybutyrates, Linoleic Acids, Male, Muscles, Oleic Acids, Oxygen Consumption, Palmitic Acids, Regional Blood Flow, Statistics as Topic, Time Factors, Veins

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