Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels
Abstract
Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O 2 concentration, redox state, and activity of the mitochondrial complexes. It is well known that the FADH 2-linked substrate succinate induces reverse electron flow to complex I of the electron transport chain and that this process generates superoxide (O 2•−); these effects are blocked by the complex I blocker rotenone. We demonstrated recently that succinate + rotenone-dependent H 2 O 2 production in isolated mitochondria increased mildly on activation of the putative big mitochondrial Ca 2+-sensitive K+ channel (mtBK Ca) by low concentrations of 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2 H-benzimidazol-2-one (NS-1619). In the present study we examined effects of NS-1619 on mitochondrial O 2 consumption, membrane potential (ΔΨ m), H 2 O 2 release rates, and redox state in isolated guinea pig heart mitochondria respiring on succinate but without rotenone. NS-1619 (30 μM) increased state 2 and state 4 respiration by 26 ± 4% and 14 ± 4%, respectively; this increase was abolished by the BK Ca channel blocker paxilline (5 μM). Paxilline alone had no effect on respiration. NS-1619 did not alter ΔΨ m or redox state but decreased H 2 O 2 production by 73% vs. control; this effect was incompletely inhibited by paxilline. We conclude that under substrate conditions that allow reverse electron flow, matrix K+ influx through mtBK Ca channels reduces mitochondrial H 2 O 2 production by accelerating forward electron flow. Our prior study showed that NS-1619 induced an increase in H 2 O 2 production with blocked reverse electron flow. The present results suggest that NS-1619-induced matrix K+ influx increases forward electron flow despite the high reverse electron flow, and emphasize the importance of substrate conditions on interpretation of effects on mitochondrial bioenergetics.
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PGC-1α, a major regulator of oxidative metabolism and mitochondrial biogenesis, is believed to regulate the mitochondrial antioxidant defense system.
“For example, a transcriptional coactivator, (PPAR)-γ coactivator 1-α (PGC-1α), a major regulator of oxidative metabolism and mitochondrial biogenesis, is believed to regulate the mitochondrial antioxidant defense system (153, 312).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [153]
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Self-citation
- Authors
- Heinen, A., Aldakkak, M., Stowe, D. F., Rhodes, S. S., Riess, M. L., Varadarajan, S. G., & Camara, A. K. S.
- Affiliations
- Medical College of Wisconsin (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2007-09
- Volume
- 293
- Issue
- 3
- Pages
- H1400-H1407
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2142188717
- Cited by
- 103
- References
- 42
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (K01HL073246, K01-HL-73246-02)
- National Eye Institute (P30 EY01931, P30EY001931)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- reverse electron flow, reactive oxygen species, NS1619, paxilline, superoxide, hydrogen peroxide production, complex I, electron transport chain, mitochondrial respiration, heart mitochondria, substrate conditions
- MeSH terms
- Animals, Benzimidazoles, Guinea Pigs, Hydrogen Peroxide, Indoles, Mitochondria, Heart, Oxidation-Reduction, Potassium, Reactive Oxygen Species, Cell Respiration, Potassium Channels, Calcium-Activated, Potassium Channel Blockers, Membrane Potential, Mitochondrial
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