The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin
Open accessAbstract
We tested the hypothesis that children with chronic relapsing colitis induced by Clostridium difficile toxin have defective antibody responses to C. difficile toxins as a cause of their underlying illness. Six such children were tested for serum IgG and IgA antibody to C. difficile toxin A. These six children had lower IgG anti-toxin A levels than 24 healthy children (p = 0.026) and 18 healthy adults (p = 0.0008). Five patients treated with 400 mg intravenously administered gamma-globulin per kilogram every 3 weeks had significant increases in IgG (p = 0.01) but not IgA anti-toxin A (p = 0.406) levels, and all five had clinical resolution of their gastrointestinal symptoms as well as clearing of C. difficile cytotoxin B from their stools. These observations suggest that a deficiency of IgG anti-toxin A may predispose children to the development of chronic relapsing C. difficile-induced colitis. In such cases, intravenous gamma-globulin therapy may be effective in producing clinical remission.
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Cites
SERUM LEVELS OF IMMUNE GLOBULINS IN HEALTH AND DISEASE: A SURVEY
Stiehm, E. R., & Fudenberg, H. H. (1966) · Pediatrics · doi:10.1542/peds.37.5.715 · Cited by 655
Clostridium difficile: its disease and toxins
Lyerly, D. M., Krivan, H. C., & Wilkins, T. D. (1988) · Clinical Microbiology Reviews · doi:10.1128/cmr.1.1.1 · Cited by 576
Leung, D. M., Kurt-Jones, E., Newburger, J., Cotran, R., Burns, J., & Pober, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91910-7 · Cited by 381
Self-citationPurification and characterization of toxins A and B of Clostridium difficile
Sullivan, N. M., Pellett, S., & Wilkins, T. D. (1982) · Infection and Immunity · doi:10.1128/iai.35.3.1032-1040.1982 · Cited by 368
Biological activities of toxins A and B of Clostridium difficile
Lyerly, D. M., Lockwood, D. E., Richardson, S. H., & Wilkins, T. D. (1982) · Infection and Immunity · doi:10.1128/iai.35.3.1147-1150.1982 · Cited by 258
Differential effects of Clostridium difficile toxins A and B on rabbit ileum
Triadafilopoulos, G., Pothoulakis, C., O'Brien, M. J., & LaMont, J. T. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)91014-6 · Cited by 204
Self-citationSerum Antibody Response to Toxins A and B of Clostridium difficile
Viscidi, R., Laughon, B. E., Yolken, R., Bo-Linn, P., Moench, T., Ryder, R. W., & Bartlett, J. G. (1983) · Journal of Infectious Diseases · doi:10.1093/infdis/148.1.93 · Cited by 204
Relapsing Clostridium difficile Enterocolitis Cured by Rectal Infusion of Normal Faeces
Schwan, A., Sjolin, S., Trottestam, U., & Aronsson, B. (1984) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548409087145 · Cited by 201
RELAPSING CLOSTRIDIUM DIFFICILE ENTEROCOLITIS CURED BY RECTAL INFUSION OF HOMOLOGOUS FAECES
SCHWAN, A. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90753-5 · Cited by 196
JACKSON, J. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90886-6 · Cited by 185
Cited by
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690
Self-citationClostridium difficile Infection
Leffler, D. A., & Lamont, J. T. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1403772 · Cited by 1,450
Self-citationClostridium difficile— More Difficult Than Ever
Kelly, C. P., & LaMont, J. T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0707500 · Cited by 1,313
Self-citationAsymptomatic Carriage of Clostridium difficile and Serum Levels of IgG Antibody against Toxin A
Kyne, L., Warny, M., Qamar, A., & Kelly, C. P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002103420604 · Cited by 935
Self-citationKyne, L., Warny, M., Qamar, A., & Kelly, C. P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03592-3 · Cited by 804
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Metadata
- Authors
- Leung, D. Y. M., Kelly, C. P., Boguniewicz, M., Pothoulakis, C., LaMont, J. T., & Flores, A.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1991-04
- Volume
- 118
- Issue
- 4
- Pages
- 633-637
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2010075812
- Cited by
- 278
- References
- 16
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin. https://app.cochat.ai/papers/10.1016/s0022-3476(05)83393-1
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- Leung, D. Y. M., Kelly, C. P., Boguniewicz, M., Pothoulakis, C., LaMont, J. T., & Flores, A. (1991). Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin. The Journal of Pediatrics. https://doi.org/10.1016/s0022-3476(05)83393-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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