Prolonged half-life of caffeine in healthy term newborn infants

Parsons, William D.; Neims, Allen H.

doi:10.1016/s0022-3476(81)80784-6

Cited by 54Coffee research and impactsPharmacogenetics and Drug MetabolismPharmaceutical studies and practices

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Prolonged half-life of caffeine in healthy term newborn infants

Parsons, William D., Neims, Allen H.·1981·The Journal of Pediatrics

DOI 10.1016/s0022-3476(81)80784-6

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Caffeine is eliminated more slowly during early infancy, requiring perhaps 80 h in preterm and healthy-term neonates, because of the reduced efficiency of cytochrome P450.
“Caffeine is eliminated more slowly during early infancy, requiring perhaps 80 h in preterm and healthy-term neonates, because of the reduced efficiency of cytochrome P450 (62, 63).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [63]

Effect of smoking on caffeine clearance
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Parsons, 1976, Caffeine elimination in pregnancy, Clin Res, 24, 652A

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Authors: Parsons, W. D., & Neims, A. H.
Affiliations: University of Florida (US)
Corresponding author: Neims, Allen H.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 1981-04
Volume: 98
Issue: 4
Pages: 640-641
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/s0022-3476(81)80784-6
OpenAlex: W2136300164
Cited by: 54
References: 8
Citations by year: 2026: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2015: 1 · 2013: 1 · 2012: 3
FWCI: 0.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: caffeine, half-life, neonates, caffeine clearance, oxidative metabolism, transplacental transfer, breast milk, neonatal pharmacokinetics, preterm infants
MeSH terms: Caffeine, Fetal Blood, Half-Life, Humans, Infant, Newborn

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Prolonged half-life of caffeine in healthy term newborn infants

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