ANTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9-TETRAHYDROCANNABINOL (THC)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The synthetic cannabinoid agonist HU-210 restores the carrageenan-induced reduction in weight bearing in rats.
“For example, the synthetic cannabinoid agonist HU-210 restores the carrageenan-induced reduction in weight bearing in rats (Clayton et al, 2002;Elmes et al, 2005;Sofia et al, 1973).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Sofia et al, 1973
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
Richardson, J. D., Kilo, S., & Hargreaves, K. (1998) · Pain · doi:10.1016/s0304-3959(97)00213-3 · Cited by 498 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Iwamura, H., Suzuki, H., Ueda, Y., Kaya, T., & Inaba, T. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38760-9 · Cited by 200 · see citing works
Conti, S., Costa, B., Colleoni, M., Parolaro, D., & Giagnoni, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704466 · Cited by 189 · see citing works
Martin, W. J., Hohmann, A. G., & Walker, J. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06601.1996 · Cited by 172 · see citing works
Ruhaak, L. R., Felth, J., Karlsson, P. C., Rafter, J. J., Verpoorte, R., & Bohlin, L. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.774 · Cited by 154 · see citing works
Hohmann, A. G., Tsou, K., & Walker, J. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.575 · Cited by 126 · see citing works
Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase
Naidu, P. S., Kinsey, S. G., Guo, T. L., Cravatt, B. F., & Lichtman, A. H. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.164806 · Cited by 108 · see citing works
Rock, E. M., Limebeer, C. L., & Parker, L. A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5034-1 · Cited by 107 · see citing works
The role of endocannabinoids in pain modulation
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works
Interaction of the cannabinoid and opioid systems in the modulation of nociception
Welch, S. P. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782794 · Cited by 92 · see citing works
Kinsey, S. G., Naidu, P. S., Cravatt, B. F., Dudley, D. T., & Lichtman, A. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.022 · Cited by 87 · see citing works
Strangman, N. M., & Walker, J. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.472 · Cited by 81 · see citing works
Synergy between Δ9-tetrahydrocannabinol and morphine in the arthritic rat
Cox, M. L., Haller, V. L., & Welch, S. P. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.010 · Cited by 78 · see citing works
“Sofia et al. (1973) demonstrated that Δ 9 - THC is effective in the paw-pressure test for mechanical nociception in rats.”
Craft, R. M., Kandasamy, R., & Davis, S. M. (2013) · Pain · doi:10.1016/j.pain.2013.05.017 · Cited by 71 · see citing works
“For example, female rodents have been found to be more sensitive than males to the antinociceptive [9,28,30], motoric [29,32], hypothermic [2,33], reinforcing [12], and cognition-impairing [5] effects of cannabinoid agonists.”
Cannabinoids Activate Monoaminergic Signaling to Modulate KeyC. elegansBehaviors
Oakes, M., Law, W. J., Clark, T., Bamber, B. A., & Komuniecki, R. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3151-16.2017 · Cited by 62 · see citing works
Prospects for cannabinoids as anti‐inflammatory agents
Zurier, R. B. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10291 · Cited by 57 · see citing works
Dogrul, A. B., Seyrek, M., Yalçın, B., & Ulugöl, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.007 · Cited by 52 · see citing works
Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins
Tubaro, A., Giangaspero, A., Sosa, S., Negri, R., Grassi, G., Casano, S., Loggia, R. D., & Appendino, G. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.04.009 · Cited by 47 · see citing works
Pertwee, R. G. (1974) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1974.tb10674.x · Cited by 41 · see citing works
Physiological roles of 2‐arachidonoylglycerol, an endogenous cannabinoid receptor ligand
Sugiura, T. (2009) · BioFactors · doi:10.1002/biof.18 · Cited by 40 · see citing works
STIMULATION OF THE HYPOTHALAMO‐PITUITARY‐ADRENAL AXIS BY COMPOUNDS FORMED IN INFLAMED TISSUE
Leme, J. G., & Schapoval, E. E. S. (1975) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1975.tb07332.x · Cited by 39 · see citing works
Roulette, C. J., Kazanji, M., Breurec, S., & Hagen, E. H. (2015) · American Journal of Human Biology · doi:10.1002/ajhb.22740 · Cited by 33 · see citing works
Chemistry and pharmacology of cannabis
Seth, R., & Sinha, S. (1991) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7136-5_3 · Cited by 27 · see citing works
RECENT ADVANCES IN THE USE OF CANNABINOIDS AS THERAPEUTIC AGENTS
Mechoulam, R., Lander, N., Srebnik, M., Zamir, I., Breuer, A., Shalita, B., Dikstein, S., Carlini, E. A., Leite, J. R., Edery, H., et al. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-044620-9.50056-7 · Cited by 18 · see citing works
Compton, D. M., Harris, L. S., Lichtman, A. H., & Martin, B. R. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60963-3_3 · Cited by 13 · see citing works
Cannabis: Structure-Activity Relationships
Sofia, R. D. (1978) · Springer eBooks · doi:10.1007/978-1-4684-3186-5_6 · Cited by 10 · see citing works
Self-citationAcute Pressure Block of the Sciatic Nerve Relieves Clinical Pain But Not Cold Pressor Pain
He, J., Jiang, X., Zhao, B., Xu, S., Zhang, F., Wei, P., & Chen, Q. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181c8fc68 · Cited by 5 · see citing works
Anti-Inflammatory Agents of Animal Origin
Smith, M. J. H., & Ford‐Hutchinson, A. W. (1979) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-66891-3_20 · Cited by 5 · see citing works
Jenkins, B. W., Moore, C. F., & Weerts, E. M. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103625 · Cited by 4 · see citing works
Harris, L. S., Dewey, W. L., & Razdan, R. K. (1977) · Springer eBooks · doi:10.1007/978-3-642-66709-1_4 · Cited by 4 · see citing works
The Endocannabinoid System in Local and Systemic Inflammation
Kelly, M. E. M., Lehmann, C., & Zhou, J. (2017) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00151ed1v01y201702isp074 · Cited by 3 · see citing works
Prostaglandins and Cannabis — IV: A Biochemical Basis for Therapeutic Applications
BURSTEIN, S. H. (1976) · Springer eBooks · doi:10.1007/978-1-4613-4286-1_2 · Cited by 3 · see citing works
Marijuana and Cannabinoids for Pain
Furnish, T. J., & Wallace, M. S. (2016) · Springer eBooks · doi:10.1007/978-3-319-30964-4_7 · Cited by 2 · see citing works
Cannabis Derivatives as Ingredients of Functional Foods to Combat the COVID-19 Pandemic
Qin, X., Yang, X., Deng, Y., Guo, L., Li, Z., Yang, X., & Hou, C. (2025) · Foods · doi:10.3390/foods14162830 · Cited by 1 · see citing works
Involvement of Serotonergic System in Cannabinoid Analgesia
Dogrul, A. B., Seyrek, M., Yalçın, B., & Ulugöl, A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7940-6_13 · Cited by 1 · see citing works
The Delta Opioid Receptor Subtypes and Pain Modulation
Ossipov, M. H., Lai, J. Y., Vanderah, T. W., et al. (2003) · CRC Press eBooks · doi:10.1201/9780203025765.pt3 · Cited by 1 · see citing works
Arrigo-Reina, R., Cosentino, C., Reina, M., et al. (1984) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-69132-4_97
Pertwee, R. G. (2003) · CRC Press eBooks · doi:10.1201/9780203911259.ch56
The chemistry and pharmacology of tetrahydrocannabinol and cannabidiol
Jana, C. E., Mwambyale, T., Chirambo, G., Gwedela, M. N. V., Chimphepo, L., & Chikowe, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95927-8.00019-0
- Authors
- SOFIA, R. D., NALEPA, S. D., HARAKAL, J. J., & VASSAR, H. B.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1973-09
- Volume
- 186
- Issue
- 3
- Pages
- 646-655
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W4407040822
- Cited by
- 41
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- delta-9-tetrahydrocannabinol, THC, analgesia, edema, pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review