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Cited by 343

The DOI matches its Crossref record.

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

Blasberg, R G, Patlak, C, Fenstermacher, J D·1975·The Journal of Pharmacology and Experimental Therapeutics
DOI 10.1016/s0022-3565(25)30311-3
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Abstract

Ventriculocisternal perfusions with five isotopically labeled drugs were performed in the rhesus monkey and the resultant tissue diffusion concentration profiles in caudate nucleus were analyzed. The periventricular distribution space with respect to perfusate concentration was measured and expressed as microliters per 100 mg wet weight: hydroxyurea = 56; methotrexate = 27; thiotepa = 28; 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) = 64 and cytosine arabinoside greater than 170. The apparent diffusion constants in caudate nucleus were determined for hydroxyurea and methotrexate (2.0 and 1.2 X 10(-6) cm2/sec, respectively); capillary permeability expressed as an extracellular space-transcapillary exchange half-time was estimated to be greater than 2 hours for both compounds. The extracellular fluid-transcapillary half-time was measured for thiotepa and BCNU (1.0 and 0.8 minute, respectively). Cytosine arabinoside continued to be concentrated by periventricular caudate nucleus during the course of perfusion; perfusate clearance measurements suggest a low capillary permeability. The apparent parenchymal diffusion constant and the capillary permeability of a drug in brain are discussed and are considered useful parameters for predicting drug levels after intrathecal administration.

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Authors
Blasberg, R. G., Patlak, C., & Fenstermacher, J. D.
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
1975-10
Volume
195
Issue
1
Pages
73-83
ISSN
0022-3565 (ISSN-L)
DOI
10.1016/s0022-3565(25)30311-3
OpenAlex
W2216897043
Cited by
343
References
0
FWCI
3.21
Type
journal article
Language
en
Open access
closed

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