Cited by 1,633Nitric Oxide and Endothelin EffectsPhosphodiesterase function and regulationCardiovascular Health and Disease Prevention

The DOI matches its Crossref record.

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Ignarro, L J, Lippton, H, Edwards, J C, Baricos, W H, Hyman, A L, Kadowitz, P J, Gruetter, C A·1981·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)32738-2

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0022-3565(25)32738-2

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 901–999 of 999

Increased Nitric Oxide Concentrations in Posterior Hypothalamus and Central Sympathetic Function on Nitrate Tolerance Following Subcutaneous Nitroglycerin
Ma, S., Ignarro, L. J., Byrns, R. E., & Li, X.-Y. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0218 · Cited by 19
Self-citation
Nebulized nitroglycerin in children with pulmonary hypertension secondary to congenital heart disease.
Omar, H. A., Gong, F., Sun, M., et al. (1999) · PubMed · Cited by 19
[24] Fluorometric detection of S-nitrosothiols
Kostka, P., & Park, J. K. J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01086-1 · Cited by 19
Effects of nitric oxide inhalation on pulmonary gas exchange during exercise in highly trained athletes
Durand, Mucci, SAFONT, & PREFAUT (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00480.x · Cited by 19
Comparison of hemodynamic effects and plasma cyclic guanosine monophosphate of nicorandil and nitroglycerin in patients with congestive heart failure
Tsutamoto, T., Kinoshita, M., 久永, 智., et al. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80750-4 · Cited by 19
Relaxation of Bovine Mesenteric Artery Induced by Glyceryl Trinitrate is Attenuated by Pertussis Toxin
Ahlner, J., Axelsson, K. L., Ekstram‐Ljusegren, M., et al. (1988) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1988.tb01864.x · Cited by 19
Lactate Accumulation in Isolated Hypoxic Rat Ventricular Myocardium: Effect of Different Modulators of the Cyclic GMP System
Ljusegren, M. E., & Axelsson, K. L. (1993) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1993.tb01339.x · Cited by 17
Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?
Arrigo, E., Comità, S., Pagliaro, P., Penna, C. R. R., & Mancardi, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512480 · Cited by 21
Synthesis and characterization of carnitine nitro-derivatives
Piermatti, O., Fringuelli, F., Pochini, L., Indiveri, C., & Palmerini, C. A. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.10.053 · Cited by 18
Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders
Yeo, J., Lee, J., 이상기, & Kim, W. J. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000270 · Cited by 20
The role of organic nitrates in the treatment of heart failure
Elkayam, U., Karaalp, I. S., Wani, O. R., Tummala, P. P., & Akhter, M. W. (1999) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.1999.0410255 · Cited by 18
Synthesis, Decomposition, and Vasodilator Action of Some New S-Nitrosated Dipeptides
Butler, A. R., Al‐Sa'doni, H. H., Megson, I. L., & Flitney, F. W. (1998) · Nitric Oxide · doi:10.1006/niox.1998.0172 · Cited by 18
Synthesis of novel organic nitrate esters: guanylate cyclase activation and tissue relaxation
Yang, K., Artz, J. D., Lock, J. D., et al. (1996) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/p19960001073 · Cited by 18
Phosphorylation of the PKG substrate, vasodilator-stimulated phosphoprotein (VASP), in human cultured prostatic stromal cells
Cook, A. M., & Haynes, J. M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.09.003 · Cited by 18
Nonglycemic effects of insulin
Yki‐Järvinen, H. (2003) · Clinical cornerstone · doi:10.1016/s1098-3597(03)90061-5 · Cited by 17
“Release of NO from the endothelium induces vasorelaxation of adjacent smooth muscle cells via stimulation of guanylate cyclase (Figure 4) (16).”
Background
N‐Nitrosomelatonin: synthesis, chemical properties, potential prodrug
Kirsch, M., & de GROOT, H. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00655.x · Cited by 19
The solid-state molecular structure of the S-nitroso derivative of l-cysteine ethyl ester hydrochloride
Yi, J., Khan, M. A., Lee, J., & Richter-Addo, G. B. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.03.005 · Cited by 18
“[16,17] proposed that the biological action of vasodilators such as organic nitrates, nitrites, and nitroprusside could be attributed, in part, to the intermediacy of unstable S-nitroso compounds.”
Background
RhoA/Rho kinase and nitric oxide modulate the agonist-induced pulmonary artery diameter response time
Boer, C., van der Linden, P. J. W., Scheffer, G. J., et al. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00093.2001 · Cited by 18
“An increased concentration of acetylcholine induces more endothelial Ca2 influx and therefore activates more endothelial NO synthase (NO synthase III) molecules, resulting in an increased NO release (8).”
Background
Evidence for a feedback inhibition of NO synthesis in enteric synaptosomes via a nitrosothiol intermediate
Kurjak, M., Koppitz, P. B., SCHUSDZIARRA, V., et al. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.4.g875 · Cited by 18
“Because SIN-1 was less potent in relaxing smooth muscle and generating NO than SNAP, but similarly effective in inhibiting NOS, it was suggested that even small amounts of NO present elicit significant NOS inhibition or that additional mechanisms not related to free NO might play a role (23).”
Background
Impairment of endothelium-dependent vasorelaxation in experimental atherosclerosis is dependent on gender
Kojda, G. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00268-x · Cited by 18
Enhancement of the efficacy of isosorbide dinitrate by captopril in stable angina pectoris
Metelitsa, V. I., Martsevich, S. Y., Козырева, М. П., et al. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90222-k · Cited by 18
Nitrinergic and peptidergic innervations and their inter-relationships in human colon
Gaumnitz, E. A., Sweet, M. A., Sengupta, A., et al. (1995) · Neuropeptides · doi:10.1016/0143-4179(95)90050-0 · Cited by 18
Nitric oxide causes the macroschizonts of Theileria annulata to disappear and host cells to become apoptotic
Richardson, J., Forsyth, L. M. G., Brown, C. G. D., et al. (1998) · Veterinary Research Communications · doi:10.1023/a:1005983111138 · Cited by 18
“…showed that activated bovine macrophages can produce NO and that NO, derived from S-nitroso-N-acetyl-dl -penicillamine, a well-documented producer of NO (Ignarro et al., 1981), prevents T. annulata trophozoite-infected cells transforming into macroschizont-infected cell lines (Visser et al., 1995).”
Background
Persistent Inhibition of Platelets During Continuous Nitroglycerin Therapy Despite Hemodynamic Tolerance
́bert, D. H., Xiang, J.-X., & Lam, J. Y. T. (1997) · Circulation · doi:10.1161/01.cir.95.5.1308 · Cited by 18
Vasodilators during cerebral aneurysm surgery
Abe, K. (1993) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03009775 · Cited by 18
The effects of Nω‐nitro‐L‐arginine methyl ester, sodium nitroprusside and noradrenaline on venous return in the anaesthetized cat
Bower, E. A., & Law, A. C. K. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13489.x · Cited by 18
Intragraft drug infusion as an adjunct to balloon catheter thrombectomy for salvage of thrombosed infragenicular vein grafts: A preliminary report
Walsh, D. B., Zwolak, R. M., McDaniel, M. D., et al. (1990) · Journal of Vascular Surgery · doi:10.1016/0741-5214(90)90070-q · Cited by 18
The antithrombotic effects of organic nitrates
Stamler, J. S., & Loscalzo, J. (1991) · Trends in Cardiovascular Medicine · doi:10.1016/1050-1738(91)90073-n · Cited by 18
Use of nitrates in ischemic heart disease
Abrams, J. (1992) · Current Problems in Cardiology · doi:10.1016/0146-2806(92)90008-c · Cited by 18
Possible involvement of nitroglycerin converting step in nitroglycerin tolerance
Hasegawa, K., Taniguchi, T., Takakura, K., Goto, Y., & Muramatsu, I. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00171-x · Cited by 18
Moderation of Anal Sphincter Tone With Nitric Oxide Agonists and Antagonists
Hechtman, H. B. (1996) · Archives of Surgery · doi:10.1001/archsurg.1996.01430190097023 · Cited by 18
Clinical Relevance of Nitrate Tolerance
Silber, S. (1985) · International Böhringer Mannheim symposia · doi:10.1007/978-3-642-70234-1_18 · Cited by 18
Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance
Pearson, R. J., & Butler, A. R. (2021) · Molecules · doi:10.3390/molecules26216581 · Cited by 18
“This work built on studies by others in the 1970s and 1980s, who showed that GTN’s activity was the result of NO generated in vascular smooth muscle [20,38].”
Method
Nitroglycerin: a comprehensive review in cancer therapy
Meunier, M., Yammine, A., Bettaı̈eb, A., & Plenchette, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05838-5 · Cited by 19
“NO-released by NTG is known as a direct activator of soluble guanylyl cyclase (sGC), which activates the production of guanosine monophosphate cyclic (GMPc) and ultimately results in a signaling pathway that causes vascular smooth muscle relaxation [5].”
Background
Application of nitric oxide in drug discovery and development
Bryan, N. S. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.613933 · Cited by 18
“As early as 1981, Ignarro’s group demonstrated that the bioactivities of certain pharmacological nitrogen oxide (NOx) donors were attributed to reactions with cellular thiols [68], which is several years before making the observation that NO is actually synthesized endogenously in mammalian cells.”
Background
Synthesis ofS-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines
Shah, S. U., Socha, M., Fries, I., et al. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1122676 · Cited by 17
“, GSNO offers significant protection to myocardial ischemia and SNAP is a powerful vasodilator (Ignarro et al., 1981)].”
Background
Electrochemical detection of nitric oxide and S-nitrosothiols in biological systems: Past, present & future
Fethi Bedioui, A., Ismail, A., & Griveau, S. (2018) · Current Opinion in Electrochemistry · doi:10.1016/j.coelec.2018.04.014 · Cited by 18
Plasma cysteine and glutathione are independent markers of postmethionine load endothelial dysfunction
Parodi, O., Chiara, B. C. D., Baldassarre, D., et al. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.08.017 · Cited by 17
“Sulphydryl-containing compounds, like cysteine and GSH, are required for activation of soluble guanylate cyclase by biotransformation to vasoactive nitric oxide [33].”
Background
Mechanism of vasorelaxation induced by 3′-hydroxy-5,6,7,4′-tetramethoxyflavone in the rats aortic ring assay
Tan, C. S., & Yam, M. F. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1481-9 · Cited by 17
Determination of changes in blood pressure during administration of sildenafil (Viagra®) in patients with spinal cord injury and erectile dysfunction
García-Bravo, A., Suárez-Hernández, D., Ruiz-Fernández, M. Á., et al. (2005) · Spinal Cord · doi:10.1038/sj.sc.3101846 · Cited by 17
Pegylated hemoglobins mechanisms to avoid vasoconstriction and maintain perfusion
Cabrales, P., & Friedman, J. M. (2007) · Transfusion Alternatives in Transfusion Medicine · doi:10.1111/j.1778-428x.2007.00090.x · Cited by 17
Blood vessel adaptation to gravity in a semi-arboreal snake
Conklin, D. J., Lillywhite, H. B., Olson, K. R., et al. (1996) · Journal of Comparative Physiology B · doi:10.1007/bf00387512 · Cited by 17
Nitric oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells
Liu, X., Abernethy, D. R., & Andrawis, N. S. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)01172-7 · Cited by 17
Inhalation of nebulized nitroglycerin in dogs with experimental pulmonary hypertension induced by U46619
Gong, F., Shiraishi, H., Kikuchi, Y., et al. (2000) · Pediatrics International · doi:10.1046/j.1442-200x.2000.01226.x · Cited by 17
Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications
Akhter, S., Green, J. R., Root, P. D., et al. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00031-4 · Cited by 17
Sulfur-to-nitrogen transnitrosation: transfer of nitric oxide from S-nitroso compounds to diethanolamine and the role of intermediate sulfur-to-sulfur transnitrosation
Al-Mustafa, A. H., Sies, H., & Stahl, W. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00388-2 · Cited by 17
Prolonged antagonism of α1-Adrenergic vasoconstriction in the rat liver by atrial natriuretic peptide
Bilzer, M., Paumgartner, G., & Gerbes, A. L. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90454-9 · Cited by 17
Hypoxia Increases Vasodilator Release From Internal Mammary Artery and Saphenous Vein Grafts
Pearson, P. J., Évora, P. R. B., Dışçıgıl, B., et al. (1998) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(98)00096-4 · Cited by 17
“The active component of this relaxing factor is the nitric oxide radical [4], which also is the active metabolite of nitrovasodilators such as sodium nitroprusside and nitroglycerin [5].”
Background
Site-Directed Mutagenesis Studies of Human Serum Albumin Define Tryptophan at Amino Acid Position 214 as the Principal Site for Nitrosation
Harohalli, K., Petersen, C. E., Ha, C., Feix, J. B., & Bhagavan, N. V. (2002) · Journal of Biomedical Science · doi:10.1007/bf02256578 · Cited by 16
Nitrate tolerance in heart failure: Differential venous, pulmonary and systemic arterial effects
Makhoul, N., Dakak, N., Flugelman, M. Y., Merdler, A., Shefer, A., Schneeweiss, A., Halon, D. A., & Lewis, B. S. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)91307-r · Cited by 17
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors
Vasu, D., Do, H. T., Li, H., Hardy, C. D., Awasthi, A., Poulos, T. L., & Silverman, R. B. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00782 · Cited by 17
Accurate Nitric Oxide Measurements from Donors in Cell Media: Identification of Scavenging Agents
Harding, J. L., & Reynolds, M. M. (2014) · Analytical Chemistry · doi:10.1021/ac403174e · Cited by 16
ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography
Heunisch, F., Chaykovska, L., von Einem, G. F., et al. (2017) · Medicine · doi:10.1097/md.0000000000006065 · Cited by 16
“One of the main reasons of hypoxia is a vasoconstriction caused by CM-induced decrease of nitric oxide (NO) concentration.([12,13]) Asymmetric dimethylarginine (ADMA) as an inhibitor of the endogenous NO production is an important component of this pathway.”
Background
Impact of Nutrition-Based Interventions on Athletic Performance during Menstrual Cycle Phases: A Review
Helm, M. M., McGinnis, G. R., & Basu, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126294 · Cited by 17
“In animal models, organic nitrates induced vasodilation by stimulating cyclic guanosine monophosphate (cGMP) accumulation and relaxing vascular smooth muscle [72].”
Background
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors
Vasu, D., Li, H., Hardy, C. D., Poulos, T. L., & Silverman, R. B. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116878 · Cited by 17
Potential Benefits of Peroxynitrite
Nossaman, B. D., & Kadowitz, P. J. (2008) · The Open Pharmacology Journal · doi:10.2174/1874143600802010031 · Cited by 15
Self-citation
Amperometric Nitrosothiol Sensor Using Immobilized Organoditelluride Species as Selective Catalytic Layer
Hwang, S., Cha, W., & Meyerhoff, M. E. (2007) · Electroanalysis · doi:10.1002/elan.200704053 · Cited by 16
Acute and subacute toxicity and efficacy of S-nitrosylated captopril, an ACE inhibitor possessing nitric oxide activities
Jia, L., Pei, R., Lin, M., & Yang, X. (2001) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00079-5 · Cited by 16
Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents
Fazzari, M., Woodcock, S. R., Rowart, P., Ricart, K. C., Lancaster, J. R., Patel, R. P., Vitturi, D. A., Freeman, B. Α., & Schopfer, F. J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101913 · Cited by 16
“For example, NTG undergoes diverse chemical reactions with heme proteins and oxidoreductases to yield NO2− and Snitrosothiols [33,40].”
Background
Pb2+ Inhibition of Sympathetic α7-Nicotinic Acetylcholine Receptor-Mediated Nitrergic Neurogenic Dilation in Porcine Basilar Arteries
Si, M.-L., & Lee, T. J.-F. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046854 · Cited by 16
“The relaxation induced by sodium nitroprusside, which is known to release NO upon entering the smooth muscle cells (Ignarro et al., 1981) was not affected by lead, indicating that lead blockade of nitrergic neurogenic vasodilation induced by nicotine and choline was not due to blockade of NO-cGMP…”
Background
In Vivo Cardioprotection by N-Acetylcysteine and Isosorbide 5-Mononitrate in a Rat Model of Ischemia-Reperfusion
Calvillo, L., Masson, S., Salio, M., et al. (2003) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1026182404805 · Cited by 16
Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: in vitro and in vivo studies
Salvemini, D., Pistelli, A., & Mollace, V. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13587.x · Cited by 16
Enhanced vasoconstrictor responses in renal and femoral arteries of the golden hamster during hibernation
Karoon, P., Knight, G. E., & Burnstock, G. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.927bd.x · Cited by 16
“SNP spontaneously releases NO in aqueous solution, which subsequently diffuses into smooth muscle and causes nonreceptor-mediated relaxation by stimulation of cGMP (Ignarro et al. 1981).”
Background
Relationship between Chronic Hypoxia and In Vitro Pulmonary Relaxation Mediated by Endothelium-Derived Relaxing Factors in Human Chronic Obstructive Lung Disease
Dinh‐Xuan, A. T., HIGENBOTTAM, T. W., & Wallwork, J. L. (1992) · Angiology · doi:10.1177/000331979204300410 · Cited by 16
The nature and importance of changes in toe-brachial pressure indices following percutaneous transluminal angioplasty for leg ischaemia
Ray, S. A., Buckenham, T. M., Belli, A.-M., et al. (1997) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(97)80209-2 · Cited by 16
Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations
Manning, J. J., Wirz, A. A., & McColl, K. E. L. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701452332 · Cited by 15
“Neuronally released NO and NO donors such as nitrosothiols relax the body of the oesophagus, the lower oesophageal sphincter (LOS) [6] and also the body of the stomach [7].”
Background
Nitric oxide enhances expression of raf kinase inhibitor protein in keratinocytes
Tsao, D., Yu, H., & Chang, H. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00811.x · Cited by 16
Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity
Bauer, J. A., & Fung, H. (1991) · Pharmaceutical Research · doi:10.1023/a:1015824417569 · Cited by 16
The Reactions of 3,5-Dibromo-4-nitrosobenzenesulfonate and its Biological Applications
Ichimori, K., Arroyo, C. M., Prónai, L., et al. (1993) · Free Radical Research Communications · doi:10.3109/10715769309056s129 · Cited by 16
Adrenotensin: An adrenomedullin gene product contracts pulmonary blood vessels
Gümüşel, B., Chang, J., Hao, Q., et al. (1996) · Peptides · doi:10.1016/0196-9781(95)02150-7 · Cited by 16
Self-citation
RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA‐PIG TRACHEAL SMOOTH MUSCLE
Takagi, K., & Araki, N. (1993) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1993.tb01676.x · Cited by 16
Nitrate resistance and tolerance: Potential limitations in the treatment of congestive heart failure
Elkayam, U., Mehra, A., Shotan, A., et al. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90601-t · Cited by 16
A Flavoprotein Mechanism Appears to Prevent an Oxygen-Dependent Inhibition of cGMP-Associated Nitric Oxide–Elicited Relaxation of Bovine Coronary Arteries
Iesaki, T., Gupte, S. A., & Wolin, M. S. (1999) · Circulation Research · doi:10.1161/01.res.85.11.1027 · Cited by 16
Differential modulation of nitric oxide and prostacyclin release in senescent rat heart stimulated by angiotensin II
Ishihata, A., Katano, Y., Nakamura, M., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00575-0 · Cited by 16
Hemodynamic and sympathetic effects of fenoldopam and sodium nitroprusside
Yakazu, Y., Iwasawa, K., Narita, H., Kindscher, J. D., Benson, K. T., & Goto, H. (2001) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2001.450920.x · Cited by 16
The Antiadhesive and Antithrombotic Effects of the Nitric Oxide Donor SIN-1 Are Combined With a Decreased Vasoconstriction in a Porcine Model of Balloon Angioplasty
Provost, P., Tremblay, J., & Merhi, Y. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.9.1806 · Cited by 16
Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs
Kodama, K., Adachi, H., Mori, N., et al. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90528-2 · Cited by 16
Interaction between hemoglobin and glutathione in the regulation of blood flow in normal and septic pigs*
Tejedor, C., Lorente, J. A., Delgado, M. A., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200211000-00015 · Cited by 16
“Snitrosothiols have recently been identified in vivo (38, 39, 47) and appear to be more potent smooth muscle relaxants than nitric oxide itself (42, 48–51).”
Background
Impaired cyclic nucleotide‐mediated vasorelaxation may contribute to closure of the human umbilical artery after birth
Renowden, S. A., Edwards, D. H., & Griffith, T. M. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14339.x · Cited by 16
Effects of Methylene Blue on the Uptake, Release and Metabolism of Noradrenaline in Mesenteric Arterial Vessels
Soares-da-Silva, P., & Caramona, M. M. (1988) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1988.tb05297.x · Cited by 16
The chemistry of hydropersulfides (RSSH) as related to possible physiological functions
Fukuto, J. M. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109659 · Cited by 18
Dependence of product formation from decomposition of nitroso-dithiols on the degree of nitrosation. Evidence that dinitroso-dithiothreitol acts solely as an nitric oxide releasing compound
Liebeskind, S., Korth, H., de GROOT, H., & Kirsch, M. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b801583j · Cited by 15
Effect of Shenmai injection on preventing the development of nitroglycerin-induced tolerance in rats
Zhou, Q., Sun, Y., Tan, W., Liu, X., Qian, Y., Ma, X., Wang, T., Wang, X., & Gao, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176777 · Cited by 15
Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels
Neubauer, R., Wölkart, G., Opelt, M., Schwarzenegger, C., Hofinger, M., Neubauer, A., Kollau, A., Schmidt, K., Schrammel, A., & Mayer, B. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.021 · Cited by 15
“Besides the non-enzymatic reaction of GTN with cysteine [1, 2] or ascorbate [3], several enzymes were proposed to catalyze GTN bioactivation, in particular GSH-S-transferase [4, 5], cytochrome P450 [6, 7], cytochrome P450 reductase [8] and xanthine oxidase, which exhibits nitrite reductase activity at low oxygen tensi…”
BackgroundMethod
Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone
Nortcliffe, A., Fleming, I. N., Botting, N. P., & O’Hagan, D. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.09.004 · Cited by 16
Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension
Šimko, F., Matusková, J., Luptak, I., et al. (2007) · Physiological Research · doi:10.33549/physiolres.931394 · Cited by 15
Preventive Effects of Angiotensin-Converting Enzyme Inhibitors on Nitrate Tolerance During Continuous Transdermal Application of Nitroglycerin in Patients With Chronic Heart Failure
Watanabe, H., Kakihana, M., Ohtsuka, S., et al. (1998) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.62.353 · Cited by 15
S-nitroso-N-acetylpenicillamine (SNAP) During Hemorrhagic Shock Improves Mortality as a Result of Recovery From Vascular Hyporeactivity
Sato, S., Suzuki, A. K., Nakajima, Y., et al. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200002000-00023 · Cited by 15
Structure-activity relationship of a novel K+ channel opener, KRN4884, and related compounds in porcine coronary artery
Izumi, H., Tanaka, Y., Okada, Y., et al. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)02139-6 · Cited by 15
Effects of indapamide on endothelium-dependent relaxations in isolated canine femoral arteries
Schini, V. B., Dewey, J., & Vanhoutte, P. M. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90336-y · Cited by 15
Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
Webb, A., & Ahluwalia, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00017-4 · Cited by 15
Potentiation of retinoic acid-induced U-937 differentiation into respiratory burst-competent cells by nitric oxide donors
Yamazaki, A., & Birnboim, H. C. (1995) · Leukemia Research · doi:10.1016/0145-2126(94)00125-t · Cited by 15
Novel mode of nitric oxide neurotransmission mediated via S‐nitroso‐cysteinyl‐glycine
Salt, T. E., Zhang, H., Mayer, B., Benz, B., Binns, K. E., & Do, K. Q. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00285.x · Cited by 15
Vascular endothelium and nitric oxide in childhood hypertension
Goonasekera, C. D. A., & Dillon, M. J. (1998) · Pediatric Nephrology · doi:10.1007/s004670050527 · Cited by 15
Gadolinium Chloride Inhibition of Pulmonary Nitric Oxide Production and Effects on Pulmonary Circulation in the Rabbit
Adding, C., Bannenberg, G. L., & Gustafsson, L. E. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01435.x · Cited by 15
A possible role of S-nitrosothiols at the nitrergic relaxations in the mouse corpus cavernosum
Göçmen, C., Seçilmiş, A., Uçar, P., et al. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00703-1 · Cited by 15
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat
Dumas, M., Dumas, J., Rochette, L., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15237.x · Cited by 15
Do nitrates differ?
Fung, H. L. (1992) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1992.tb04141.x · Cited by 15
Identification of nitroglycerin-induced cysteine modifications of pro-matrix metalloproteinase-9
Krishnatry, A. S., Kamei, T., Wang, H., Qu, J., & Fung, H. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5118 · Cited by 9

Authors: Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A.
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1981-09
Volume: 218
Issue: 3
Pages: 739-749
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)32738-2
OpenAlex: W1907994445
Cited by: 1,633
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 14 · 2018: 23 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 27
FWCI: 18.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: vasorelaxation, organic nitrates, nitrite, sodium nitroprusside, nitric oxide, S-nitrosothiols, guanylate cyclase activation, cyclic GMP, nitroglycerin, isosorbide dinitrate, PETN, amyl nitrite, sodium nitrite, sulfhydryl groups, coronary arteries
MeSH terms: Animals, Biotransformation, Cats, Cattle, Coronary Vessels, Enzyme Activation, Female, Ferricyanides, Guanylate Cyclase, Hemodynamics, Male, Nitrates, Nitric Oxide, Nitrites, Nitroprusside, Nitroso Compounds, Vasodilator Agents, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks