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Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
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“Nitrite metabolism can be activated by hypoxia, low pH and reactions with metalloproteins[50–58].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [50]
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“…500 μ l of supernatants were collected and subsequently 500 μ l new cell media containing 200 μ M or 400 μ M of SNAP or NAP, respectively, were added to the wells, which effectively adds half of the final tested concentration and accounts for SNAP ’ s short half-life of approximately 4.6 h [14].”
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Metadata
- Authors
- Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1981-09
- Volume
- 218
- Issue
- 3
- Pages
- 739-749
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1907994445
- Cited by
- 1,633
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 14 · 2018: 23 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 27
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- vasorelaxation, organic nitrates, nitrite, sodium nitroprusside, nitric oxide, S-nitrosothiols, guanylate cyclase activation, cyclic GMP, nitroglycerin, isosorbide dinitrate, PETN, amyl nitrite, sodium nitrite, sulfhydryl groups, coronary arteries
- MeSH terms
- Animals, Biotransformation, Cats, Cattle, Coronary Vessels, Enzyme Activation, Female, Ferricyanides, Guanylate Cyclase, Hemodynamics, Male, Nitrates, Nitric Oxide, Nitrites, Nitroprusside, Nitroso Compounds, Vasodilator Agents, In Vitro Techniques
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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