Cited by 1,633Nitric Oxide and Endothelin EffectsPhosphodiesterase function and regulationCardiovascular Health and Disease Prevention

The DOI matches its Crossref record.

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Ignarro, L J, Lippton, H, Edwards, J C, Baricos, W H, Hyman, A L, Kadowitz, P J, Gruetter, C A·1981·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)32738-2

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0022-3565(25)32738-2

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 801–900 of 999

Pharmacodynamic Hybrids Coupling Established Cardiovascular Mechanisms of Action with Additional Nitric Oxide Releasing Properties
Martelli, A., Breschi, M. C., & Calderone, V. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787315611 · Cited by 26
“According to this hypothesis, molecules containing SH groups, such as cysteine or glutathione, appeared indispensable for the conversion of organic nitrates into NO or S-nitrosothiols [53].”
Background
Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins
Huellner, M. W., Schrepfer, S., Weyand, M., Weiner, H., Wimplinger, I., Thomas Eschenhagen, A., & Rau, T. (2008) · The FASEB Journal · doi:10.1096/fj.07-098830 · Cited by 26
“vate GTN (2), in contrast to the endogenous endothe-”
BackgroundResultInfluential
Nitrite potentiates the vasodilatory signaling of S-nitrosothiols
Liu, T., Zhang, M., Terry, M. H., Schroeder, H. J., Wilson, S. M., Power, G. G., Li, Q., Tipple, T. E., Borchardt, D., & Blood, A. B. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.01.011 · Cited by 23
Nitric oxide and prostacyclin inhibit fetal platelet aggregation: A response similar to that observed in adults
Varela, A. F., Runge, A., Ignarro, L. J., et al. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91748-y · Cited by 25
Self-citation
Nitrosonium-Catalyzed Decomposition of S-Nitrosothiols in Solution: A Theoretical and Experimental Study
Zhao, Y., McCarren, P. R., Houk, K. N., Choi, B. Y., & Toone, E. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050018f · Cited by 25
Reproducible uniform coronary vasomotor tone with nitrocompounds: Prerequisite of quantitative coronary angiographic trials
Jost, S., Rafflenbeul, W., Rell, G., et al. (1990) · Catheterization and Cardiovascular Diagnosis · doi:10.1002/ccd.1810200304 · Cited by 25
Pharmacology of the nitrates in angina pectoris
Frishman, W. H. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90701-5 · Cited by 25
Relationship between the inhibition of receptor-induced increase in cytosolic free calcium concentration and the vasodilator effects of nitrates in patients with congestive heart failure
Negrescu, E. V., Ln, S., Baldenkov, G. N., et al. (1990) · International Journal of Cardiology · doi:10.1016/0167-5273(90)90031-y · Cited by 25
Intracavernous Sodium Nitroprusside: Inappropriate Impotence Treatment
Brock, G. B., Breza, J., Jr., & Lue, T. F. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35634-3 · Cited by 22
Efficacy of Nitroglycerin Patches: Fact or Fancy?
Parker, J. O. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-102-4-548 · Cited by 25
Effect of Cu2+ on relaxations to the nitrergic neurotransmitter, NO and S‐nitrosothiols in the rat gastric fundus
Man, J. G. D., Winter, B. Y. D., Boeckxstaens, G. E., Herman, A. G., & Pelckmans, P. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15769.x · Cited by 25
Hemodynamic Evaluation of Molsidomine: A Vasodilator With Antianginal Properties in Patients With Alcoholic Cirrhosis
Vinel, J., Monnin, J.-L., Combis, J.-M., et al. (1990) · Hepatology · doi:10.1002/hep.1840110213 · Cited by 25
“Like organic nitrates, nitroprusside and atrial natriuretic factor, molsidomine elicits vascular smooth muscle relaxation through activation of guanylate cyclase and accumulation of cyclic guanylic acid (11, 12).”
Background
Redox regulation of guanylate cyclase and protein kinase G in vascular responses to hypoxia
Neo, B. H., Kandhi, S., Ahmad, M., & Wolin, M. S. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.08.024 · Cited by 24
Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis
Rotta, J. C. G., Lunardi, C. N., & Tedesco, A. C. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003000500005 · Cited by 25
Synthesis of 2′-thio-uridine and -cytidine derivatives as potential inhibitors of ribonucleoside diphosphate reductase: thionitrites, disulfides and 2′-thiouridine 5′-diphosphate
de Fallois, L. L. H., Décout, J., & Fontecave, M. (1997) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/a701820g · Cited by 24
Exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass—response to acetylcholine and nitroglycerin
Törnberg, D. C., Angdin, M., Settergen, G., Liška, J., Lundberg, J. O., & Weitzberg, E. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aei027 · Cited by 24
Pharmacologic Modulation of the Cutaneous Vasculature in the Isolated Perfused Porcine Skin Flap
Rogers, R. A., & Riviere, J. E. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600831208 · Cited by 24
Endothelin-1 induces potent constriction of lymphatic vessels in situ
Fortes, Z. B., Scivoletto, R., & Garcia-Leme, J. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90135-0 · Cited by 24
Butyl Nitrite Transformation In Vitro, Chemical Nitrosation Reactions, and Mutagenesis
Osterloh, J., & Goldfield, D. (1984) · Journal of Analytical Toxicology · doi:10.1093/jat/8.4.164 · Cited by 24
Escape from tolerance of organic nitrate by induction of cytochrome P450
Minamiyama, Y., Imaoka, S., Takemura, S., Okada, S., Inoue, M., & Funae, Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00733-x · Cited by 24
Methionine restores the venodilative response to nitroglycerin after the development of tolerance
Levy, W. S., Katz, R. J., & Wasserman, A. G. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80118-4 · Cited by 24
Endogenous morphine: opening new doors for the treatment of pain and addiction
Pryor, S. C., Zhu, W. M., Cadet, P., et al. (2005) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.5.7.893 · Cited by 24
“2 Nitric oxide synthase As a labile, free radical gas, NO cannot be stored by conventional means nor inactivated after synaptic release, and its biosynthesis constitutes the major means for regulating NO levels (for reviews see [2-5]).”
Background
Relationship between pharmacokinetics and hemodynamic tolerance to isosorbide-5-mononitrate
Wagner, F., Siefert, F., Trenk, D., & J�hnchen, E. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf01417565 · Cited by 23
“Based on the biochemical concept of nitrate tolerance [8], according to which continuous exposure to nitrates results in consumption of reduced sulfhydryl groups in vascular receptors required for the formation of the vasoactive nitric oxide, it is reasonable to speculate that for each organic nitrate there is a criti…”
Background
S-nitroso-N-acetylpenicillamine reduces leukocyte adhesion to type I collagen
Sundqvist, T., Forslund, T., Bengtsson, T., et al. (1994) · Inflammation · doi:10.1007/bf01535260 · Cited by 24
“S-Nitroso-Nacetylpenicillamine (SNAP) is a nitric-oxide-generating compound spontaneously releasing nitric oxide (13).”
Background
Correlation between inhibition of a cyclic GMP phosphodiesterase and relaxation of canine tracheal smooth muscle
Polson, J. B., Krzanowski, J. J., & Szentivanyi, A. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90301-6 · Cited by 24
Effect of isosorbiddinitrate on exogenously expressed slowly activating K+ channels and endogenous K+ channels in Xenopus oocytes.
Busch, A. E., Kopp, H., Waldegger, S., et al. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021253 · Cited by 24
Nitroglycerin and nitroprusside increase coronary blood flow in dogs by a mechanism independent of prostaglandin release
Panzenbeck, M. J., Baez, A., & Kaley, G. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90528-9 · Cited by 24
Advanced stent coating for drug delivery and in vivo biocompatibility
Liu, Y., Wang, W., Acharya, G., Shim, Y., Choe, E. S., & Lee, C. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-1962-1 · Cited by 23
“It transnitrosates the thiol groups in protein and endogenously generates S-nitrosothiols that prevent platelet adhesion and aggregation in vivo (Ignarro et al. 1981).”
Background
Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance
Dou, D., Ma, H., Zheng, X., Ying, L., Guo, Y., Yu, X., & Gao, Y. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp376 · Cited by 23
Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells
Buzharevski, A., Paskaš, S., Sárosi, M. B., Laube, M., Lönnecke, P., Neumann, W., Murganić, B., Mijatović, S., Maksimović‐Ivanić, D., Pietzsch, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59059-3 · Cited by 23
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Lundberg, J. O., Weitzberg, E., Shiva, S., & Gladwin, M. T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_3 · Cited by 26
Iron regulatory protein‐independent regulation of ferritin synthesis by nitrogen monoxide
Mikhael, M., Kim, S. F., Schranzhofer, M., Lin, S. S., Sheftel, A. D., Müllner, E. W., & Ponka, P. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05390.x · Cited by 23
Nitric oxide donors and angiotensin-converting enzyme inhibitors act in concert to inhibit human angiotensin-converting enzyme activity and platelet aggregation in vitro
Persson, K., Whiss, P. A., Nyhlén, K., Jacobsson-Strier, M., Glindell, M., & Andersson, R. G. G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00647-6 · Cited by 23
Subunit-specific redox modulation of nmda receptors expressed in xenopus oocytes
Omerovic, A., Chen, S.-J., Leonard, J. P., et al. (1995) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899509049859 · Cited by 23
The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide
Salvemini, D., Pistelli, A., Mollace, V., Änggård, E., & Vane, J. R. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90032-e · Cited by 22
Vasomotor Effects of Leukotrienes C4 and D4 on Cavian Pulmonary Artery and Aorta Characterization and Mechanismsa,b
Sakuma, I., & Levi, R. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb38533.x · Cited by 23
S-Nitroso-N-acetylpenicillamine is a Potent Inhibitor of Neutrophil-Endothelial Interaction
Ma, X., Lefer, A. M., & Zipkin, R. E. (1993) · Endothelium · doi:10.3109/10623329309100953 · Cited by 23
The Neuronal Nitric Oxide Synthase (nNOS) Gene and Neuroprotection Against Alcohol Toxicity
Karaçay, B., & Bonthius, D. J. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0155-0 · Cited by 22
“Both the increase in cGMP concentration and the muscle relaxation could be mimicked by NO-donors, such as nitroglycerin and exogenous NO (Arnold et al. 1977; Ignarro et al. 1981; Katsuki et al. 1977), thus strongly suggesting that the release of NO was the underlying basis for these effects.”
Background
Heat Reduces Nitric Oxide Production Required for Auxin-Mediated Gene Expression and Fate Determination in Tree Tobacco Guard Cell Protoplasts
Beard, R., Anderson, D. J., Bufford, J. L., & Tallman, G. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.200089 · Cited by 22
“At a culture pH of 6.1 (Tallman, 2005) and a SNAP concentration of 2.5 mM, and assuming a half-life of approximately 5 h (Ignarro et al., 1981) and an estimated conversion efficiency of SNAP to NO of 0.5 (Feelisch, 1991), NO concentrations 16 h after SNAP addition to cultures would be approximately…”
MethodInfluential
Platelet resistance to the antiaggregating effect of N-acetyl-l-cysteine in obese, insulin-resistant subjects
Anfossi, G., Russo, I., Massucco, P., Mattiello, L., & Trovati, M. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00284-6 · Cited by 22
Near-infrared spectroscopy can detect differences in vascular responsiveness to a hyperglycaemic challenge in individuals with obesity compared to normal-weight individuals
Soares, R. N., Reimer, R. A., Alenezi, Z., Doyle–Baker, P. K., & Murias, J. M. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117731481 · Cited by 22
Studies on Inhibition of Human Platelet Function by Sodium Nitroprusside. Kinetic Evaluation of the Effect on Aggregation and Cyclic Nucleotide Content
Anfossi, G., Russo, I., Massucco, P., et al. (2001) · Thrombosis Research · doi:10.1016/s0049-3848(01)00240-7 · Cited by 22
Short-term exposure to homocysteine depresses rat aortic contractility by an endothelium-dependent mechanism
Wang, S., Wright, G. L., Harrah, J., et al. (2000) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-78-6-500 · Cited by 22
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S‐nitrosylated Captopril, a nitric oxide donor
Jia, L., & Wong, H. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704431 · Cited by 22
“They and others had noted that S-nitrosocysteine showed close physiological and pharmacological resemblance to NO (Furchgott et al., 1992; Ignarro et al., 1981, Myers et al., 1990; Feelisch et al., 1994).”
Background
Nitric Oxide: Physiological Roles, Biosynthesis and Medical Uses
Adams, D. R., Brochwicz‐Lewinski, M., & BUTLER, A. R. (1999) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-6351-1_1 · Cited by 23
The Effect of Hydralazine on the Development of Tolerance to Continuous Nitroglycerin
Parker, J. D., Parker, A. B., Farrell, B., & Parker, J. O. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36449-3 · Cited by 22
Production and Excretion of Nitrate by Human Newborn Infants: Neonates Are Not Little Adults
Honold, J., Pusser, N. L., Nathan, L., Chaudhuri, G., Ignarro, L. J., & Sherman, M. P. (2000) · Nitric Oxide · doi:10.1006/niox.1999.0267 · Cited by 21
Self-citation
Interleukin-1β-induced, nitric oxide-dependent and -independent inhibition of vascular smooth muscle contraction
Takizawa, S., Ozaki, H., & Karaki, H. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00164-7 · Cited by 22
Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation
Lau, D., & Benet, L. Z. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90184-k · Cited by 22
Nitric oxide and cardiovascular disease
McIntyre, M., & Dominiczak, A. F. (1997) · Postgraduate Medical Journal · doi:10.1136/pgmj.73.864.630 · Cited by 22
Detection of nitric oxide from pig trachea by a fluorescence method
Lozinsky, E., Martina, L. V., Shames, A. I., et al. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2003.12.004 · Cited by 22
Effect of sildenafil on nocturnal erections of potent men
Yaman, Ö., Tokath, Z., İnal, T., et al. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900978 · Cited by 22
Reactivity of thionitrate esters: putative intermediates in nitrovasodilator activity
Artz, J. D., Yang, K., Lock, J. D., Sanchez, C., Bennett, B. M., & Thatcher, G. R. J. (1996) · Chemical Communications · doi:10.1039/cc9960000927 · Cited by 22
Contrasting effects of diethylenetriamine–nitric oxide, a spontaneously releasing nitric oxide donor, on pregnant rat uterine contractility in vitro versus in vivo
Buhimschi, C. S., Buhimschi, I. A., Yallampalli, C., et al. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70166-2 · Cited by 22
No enhancement by nitric oxide of glutamate release from P2 and P3 synaptosomes of rat hippocampus.
Kamisaki, Y., Maeda, K., Ishimura, M., Omura, H., Moriwaki, Y., & Itoh, T. (1994) · Brain Research · doi:10.1016/0006-8993(94)90355-7 · Cited by 25
NO modulates myocardial O2consumption in the nonhuman primate: an additional mechanism of action of amlodipine
Forfia, P. R., Zhang, X., Knight, D. R., Smith, A. H., Doe, C. P. A., Wolfgang, E. A., Flynn, D. M., Wolin, M. S., & Hintze, T. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.6.h2069 · Cited by 22
“Amlodipine was supplied by Pfizer (Groton, CT), whereas SNAP was synthesized as described previously (17).”
Method
Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines
Buzharevski, A., Paskaš, S., Laube, M., Lönnecke, P., Neumann, W., Murganić, B., Mijatović, S., Maksimović‐Ivanić, D., Pietzsch, J., & Hey‐Hawkins, E. (2019) · ACS Omega · doi:10.1021/acsomega.9b00412 · Cited by 21
Nitric oxide signaling in vascular biology
Bian, K., & Murad, F. (2007) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2006.11.007 · Cited by 21
Nitrates as a Treatment of Acute Heart Failure
Alzahri, M. S., Rohra, A., & Peacock, W. F. (2016) · Cardiac failure review · doi:10.15420/cfr.2016:3:3 · Cited by 21
“The decrease in intracellular calcium leads to venous and arterial vasodilation.(7,8) More recent studies suggest epigenetic regulation of nitrate-induced smooth muscle relaxation where nitroglycerin may increase histone acetylase activity, and N-lysine acetylation of contractile proteins that may then influence nitro…”
Background
Role of endothelium-derived relaxing factors in the renal response to vasoactive agents in hypothyroid rats
Moreno, J. M., Wangensteen, R., Sáinz, J., Rodríguez‐Gómez, I., Chamorro, V., Osuna, A., & Vargas, F. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00558.2002 · Cited by 21
“Thus openers of K channels inhibit leukotrienes C4 and D4 or ANG II-induced vasoconstriction (12, 16), and TEA induces a dose-dependent increase in the vascular sensitivity to norepinephrine and ANG II (21).”
Background
The Role of Nitric Oxide (Formerly Endothelium-Derived Relaxing Factor-EDRF) in Vasodilatation and Vasodilator Therapy
Tibballs, J. (1993) · Anaesthesia and Intensive Care · doi:10.1177/0310057x9302100604 · Cited by 21
Nitric Oxide Donors
Yamamoto, T., & Bing, R. J. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22525.x · Cited by 21
Immunochemical Visualization and Quantitation of Cyclic AMP in Single Cells
Wiemelt, A. P., Engleka, M. J., Skorupa, A. F., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31489 · Cited by 21
KATP Channel Activation Mediates Nicorandil-Induced Relaxation of Nitrate-Tolerant Coronary Arteries
O’Rourke, S. T. (1996) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199606000-00010 · Cited by 21
Increased Endothelium‐Dependent Vascular Relaxation in Ethanol‐Fed Rats
Hatake, K., Wakabayashi, I., Taniguchi, T., et al. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00076.x · Cited by 21
Nitrates in myocardial infarction
Jugdutt, B. I. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877417 · Cited by 21
Circulating NO Pool in Humans
Rassaf, T., Kleinbongard, P., & Kelm, M. (2005) · Kidney & Blood Pressure Research · doi:10.1159/000090188 · Cited by 21
Human Migraine Models
Iversen, H. K. (2001) · Cephalalgia · doi:10.1177/033310240102100710 · Cited by 21
Cultured astrocytoma cells generate a nitric oxide‐like factor from endogenous L‐arginine and glyceryl trinitrate: effect ofE. colilipopolysaccharide
Salvemini, D., Mollace, V., Pistelli, A., et al. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14437.x · Cited by 21
Physiological significance of endogenous nitric oxide.
Ignarro, L. J. (1991) · PubMed · Cited by 21
Self-citation
Kinetic studies on nitrite and nitrate in rats by ion-pair chromatography
Stein, C., Claßen, H.-G., & Schwedt, G. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90006-x · Cited by 21
Nitric Oxide and Nitric Oxide Synthase in the Kidney: Potential Roles in Normal Renal Function and in Renal Dysfunction
Hill‐Kapturczak, N., Kapturczak, M., Maliñski, T., & Gross, P. A. (1995) · Endothelium · doi:10.3109/10623329509024671 · Cited by 21
Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid
Minuz, P., Lechi, C., Tommasoli, R., et al. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)00189-x · Cited by 21
Nitroglycerin-induced coronary vasodilation is not enhanced in patients with impaired endothelium-dependent dilation
Anderson, T. J., Meredith, I. T., Charbonneau, F., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00221-5 · Cited by 21
Nitrates
Abrams, J. (1988) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30785-4 · Cited by 20
Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells
Beale, A. D., Hayter, E. A., Crosby, P., Valekunja, U. K., Edgar, R. S., Chesham, J. E., Maywood, E. S., Labeed, F. H., Reddy, A. B., Wright, K. P., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023114164 · Cited by 19
“…the rest phase contribute to heat loss (Fig 4A), we used sodium nitrite, a direct modifier of Hb oxidation status in vitro (Fig 1H), a common cause of methaemoglobinemia in humans (Dela Cruz et al , 2018), and a known vasodilator in vitro (Ignarro et al , 1981) and in vivo (Cosby et al , 2003).”
Role of cGMP‐dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries
Dou, D., Zheng, X., Qin, X. Y., Qi, H., Liu, L., Raj, J. U., & Gao, Y. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707600 · Cited by 20
“PKG activity assay Isolated porcine coronary arteries were incubated in serumfree Dulbecco’s modified Eagle’s medium for 24 h with NTG or DETA NONOate in the presence and absence of ODQ (3 10 5 M), an inhibitor of soluble guanylyl cyclase (Ignarro et al., 1981).”
BackgroundMethodInfluential
Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin
Ishima, Y., Yoshida, F., Kragh‐Hansen, U., et al. (2011) · Free Radical Research · doi:10.3109/10715762.2011.606814 · Cited by 20
“The sulfhydryl moiety can interact with nitric oxide (NO) and thereby form S -nitrosothiols [1-3].”
Background
One-step preparation of S-nitrosated human serum albumin with high biological activities
Ishima, Y., Hiroyama, S., Kragh‐Hansen, U., et al. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.05.002 · Cited by 20
15 Glutathione in the Nervous System: Roles in Neural Function and Health and Implications for Neurological Disease
Janáky, R., Cruz-Aguado, R., Oja, S. S., & Shaw, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-30373-4_15 · Cited by 20
Protective Effect of S-Nitrosylated α1-Protease Inhibitor on Hepatic Ischemia-Reperfusion Injury
Ikebe, N., Akaike, T., Miyamoto, Y., Hayashida, K., Yoshitake, J., Ogawa, M., & Maeda, H. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38988-8 · Cited by 55
Glial‐Neuronal Transfer of Arginine andS‐Nitrosothiols in Nitric Oxide Transmission
Kim, Q., Grima, G., Benz, B., & Salt, T. E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04058.x · Cited by 20
Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate
Christiansen, I., Iversen, H. K., Olesen, J., & Tfelt‐Hansen, P. C. (2008) · The Journal of Headache and Pain · doi:10.1007/s10194-008-0043-9 · Cited by 20
Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver
Lau, D. T. W., & Benet, L. Z. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90398-5 · Cited by 20
Pharmacokinetics and pharmacodynamics of isosorbide dinitrate
Fung, H. (1985) · American Heart Journal · doi:10.1016/0002-8703(85)90489-2 · Cited by 20
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo
de Garavilla, L., Pagani, E. D., Buchholz, R. A., et al. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00505-5 · Cited by 20
S‐nitrosothiols and the nitrergic neurotransmitter in the rat gastric fundus: effect of antioxidants and metal chelation
Man, J. G. D., Winter, B. Y. D., Moreels, T. G., Herman, A. G., & Pelckmans, P. A. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701692 · Cited by 20
“Biological activity of Snitrosothiols: the role of nitric oxide.”
BackgroundInfluential
Therapeutic potential of endothelin receptor antagonists and nitric oxide donors in pulmonary hypertension
Tilton, R. G., Brock, T. A., & Dixon, R. A. F. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.7.1291 · Cited by 20
Estrogen augments cyclopiazonic acid-mediated, endothelium-dependent vasodilation
Rahimian, R., van Breemen, C., Karkan, D., Dubé, G. P., & Laher, I. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)89653-7 · Cited by 20
Sepsis and Nitric Oxide
Avontuur, J. A. M., Bruining, H. A., & İnce, C. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0333-6_71 · Cited by 19
Neurogenic contraction and relaxation of human penile deep dorsal vein
Segarra, G., Medina, P., Domenech, C., et al. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701883 · Cited by 20
“Sodium nitroprusside relaxes smooth muscle by releasing nitric oxide within smooth muscle cells (Ignarro et al., 1981), whereas papaverine induces relaxation mainly by increases in cyclic AMP and cyclic GMP (RuÈ egg, 1992).”
Background
Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta
Slack, C. J., McLaughlin, B. E., Nakatsu, K., et al. (1988) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y88-220 · Cited by 20
Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth
Pal, H. A., Mohapatra, S., Gupta, V., Ghosh, S., & Verma, S. K. (2017) · Chemical Science · doi:10.1039/c6sc05017d · Cited by 19
Role Of Nitric Oxide On Pressor Mechanisms Within The Dorsomedial And Rostral Ventrolateral Medulla In Anaesthetized Cats
Chen, S., Mao, S., & Chai, C. Y. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03434.x · Cited by 19
N-Acetylcysteine Antagonizes the Development But Does Not Reverse ACTH-Induced Hypertension in the Rat
Mondo, C. K., Zhang, Y., Possamai, V. D. M., et al. (2006) · Clinical and Experimental Hypertension · doi:10.1080/10641960500468219 · Cited by 19
Up‐regulation of Fas (CD95) expression in tumour cells in vivo
Peshes‐Yaloz, N., Rosen, D., Sondel, P. M., Krammer, P. H., & Berke, G. (2007) · Immunology · doi:10.1111/j.1365-2567.2006.02521.x · Cited by 19
Activation of the Endothelium-Derived Relaxing Factor System in Acute Unilateral Ureteral Obstruction
Schulsinger, D. A., Gulmi, F. A., Chou, S., Mooppan, U. M. M., & Kim, H. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64908-5 · Cited by 18
Nitric oxide regulates the chemiluminescence from stimulated human neutrophils
Forslund, T., & Sundqvist, T. (1995) · Apmis · doi:10.1111/j.1699-0463.1995.tb01439.x · Cited by 18
Interactions of nitrovasodilators and atrial natriuretic peptide in isolated dog coronary arteries
Matsumoto, T., Okamura, T., Kinoshita, M., et al. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90089-z · Cited by 19
Evidence against a role of nitric oxide in the indirect negative inotropic-effect of M-cholinoceptor stimulation in human ventricular myocardium
Kilter, H., Lenz, O., Rosée, K. L., et al. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00168562 · Cited by 19

Authors: Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A.
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1981-09
Volume: 218
Issue: 3
Pages: 739-749
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)32738-2
OpenAlex: W1907994445
Cited by: 1,633
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 14 · 2018: 23 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 27
FWCI: 18.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: vasorelaxation, organic nitrates, nitrite, sodium nitroprusside, nitric oxide, S-nitrosothiols, guanylate cyclase activation, cyclic GMP, nitroglycerin, isosorbide dinitrate, PETN, amyl nitrite, sodium nitrite, sulfhydryl groups, coronary arteries
MeSH terms: Animals, Biotransformation, Cats, Cattle, Coronary Vessels, Enzyme Activation, Female, Ferricyanides, Guanylate Cyclase, Hemodynamics, Male, Nitrates, Nitric Oxide, Nitrites, Nitroprusside, Nitroso Compounds, Vasodilator Agents, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks